FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045707154> ?p ?o ?g. }

• W2045707154 endingPage "672" @default.
• W2045707154 startingPage "665" @default.
• W2045707154 abstract "The renal reabsorption of natural nucleosides and a variety of nucleoside-derived drugs relies on the function of the apically located, Na(+)-dependent, concentrative nucleoside transporters CNT1, CNT2, and CNT3 (SLC28A1, SLC28A2, and SLC28A3). The aims of this study were to determine the segmental localization of the three SLC28 family members and to establish whether streptozotocin-induced diabetes alters their expression.SLC28 expression was measured by real-time polymerase chain reaction (PCR) on microdissected sections of rat nephrons. Diabetes was induced by streptozotocin treatment and the biochemical profiles of control, diabetic, and insulin-treated rats were established. The effect of diabetes on SLC28 expression was assessed in those segments that significantly express SLC28 genes.CNT1-3 mRNAs were expressed in the proximal tubule and glomerulus. In addition, CNT2 and CNT3 mRNAs were expressed in the outer medullary and cortical collecting duct, respectively. Diabetes reduced expression of the three CNTs in almost all nephron segments, and this effect was not prevented by an insulin treatment that normalized all blood and urine parameters. Diabetes increased CNT1 and CNT3 expression in the glomerulus and insulin treatment decreased it.The relative distribution of SLC28 gene expression suggests a role for the proximal tubule in renal nucleoside clearance and an accessory role for CNT2 and CNT3, in adenosine-mediated regulation of collecting duct functions. Diabetes probably may impair nucleoside clearance independently of insulin." @default.
• W2045707154 created "2016-06-24" @default.
• W2045707154 creator A5003482799 @default.
• W2045707154 creator A5014106031 @default.
• W2045707154 creator A5051436796 @default.
• W2045707154 creator A5056171425 @default.
• W2045707154 creator A5061239413 @default.
• W2045707154 creator A5085196030 @default.
• W2045707154 creator A5090688644 @default.
• W2045707154 date "2005-08-01" @default.
• W2045707154 modified "2023-10-15" @default.
• W2045707154 title "Expression of concentrative nucleoside transporters SLC28 (CNT1, CNT2, and CNT3) along the rat nephron: Effect of diabetes" @default.
• W2045707154 cites W123909038 @default.
• W2045707154 cites W1512501096 @default.
• W2045707154 cites W1964891034 @default.
• W2045707154 cites W1967675162 @default.
• W2045707154 cites W1978285874 @default.
• W2045707154 cites W1986270813 @default.
• W2045707154 cites W1995231696 @default.
• W2045707154 cites W2000783444 @default.
• W2045707154 cites W2001497180 @default.
• W2045707154 cites W2002711182 @default.
• W2045707154 cites W2009202603 @default.
• W2045707154 cites W2017740165 @default.
• W2045707154 cites W2041270614 @default.
• W2045707154 cites W2055482409 @default.
• W2045707154 cites W2060470848 @default.
• W2045707154 cites W2076075779 @default.
• W2045707154 cites W2077516532 @default.
• W2045707154 cites W2078314585 @default.
• W2045707154 cites W2079683100 @default.
• W2045707154 cites W2087176284 @default.
• W2045707154 cites W2094900389 @default.
• W2045707154 cites W2096030406 @default.
• W2045707154 cites W2101017561 @default.
• W2045707154 cites W2102694923 @default.
• W2045707154 cites W2106734174 @default.
• W2045707154 cites W2117535436 @default.
• W2045707154 cites W2133645165 @default.
• W2045707154 cites W2140006576 @default.
• W2045707154 cites W2140070979 @default.
• W2045707154 cites W2151920020 @default.
• W2045707154 cites W2153857382 @default.
• W2045707154 cites W2154527918 @default.
• W2045707154 cites W2165919627 @default.
• W2045707154 cites W2166131221 @default.
• W2045707154 cites W2169143920 @default.
• W2045707154 cites W2175189370 @default.
• W2045707154 cites W2312798965 @default.
• W2045707154 cites W4294216491 @default.
• W2045707154 doi "https://doi.org/10.1111/j.1523-1755.2005.00444.x" @default.
• W2045707154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16014043" @default.
• W2045707154 hasPublicationYear "2005" @default.
• W2045707154 type Work @default.
• W2045707154 sameAs 2045707154 @default.
• W2045707154 citedByCount "45" @default.
• W2045707154 countsByYear W20457071542012 @default.
• W2045707154 countsByYear W20457071542013 @default.
• W2045707154 countsByYear W20457071542014 @default.
• W2045707154 countsByYear W20457071542015 @default.
• W2045707154 countsByYear W20457071542016 @default.
• W2045707154 countsByYear W20457071542017 @default.
• W2045707154 countsByYear W20457071542018 @default.
• W2045707154 countsByYear W20457071542019 @default.
• W2045707154 countsByYear W20457071542020 @default.
• W2045707154 countsByYear W20457071542022 @default.
• W2045707154 countsByYear W20457071542023 @default.
• W2045707154 crossrefType "journal-article" @default.
• W2045707154 hasAuthorship W2045707154A5003482799 @default.
• W2045707154 hasAuthorship W2045707154A5014106031 @default.
• W2045707154 hasAuthorship W2045707154A5051436796 @default.
• W2045707154 hasAuthorship W2045707154A5056171425 @default.
• W2045707154 hasAuthorship W2045707154A5061239413 @default.
• W2045707154 hasAuthorship W2045707154A5085196030 @default.
• W2045707154 hasAuthorship W2045707154A5090688644 @default.
• W2045707154 hasBestOaLocation W20457071541 @default.
• W2045707154 hasConcept C126322002 @default.
• W2045707154 hasConcept C134018914 @default.
• W2045707154 hasConcept C2776543447 @default.
• W2045707154 hasConcept C2777180221 @default.
• W2045707154 hasConcept C2778305430 @default.
• W2045707154 hasConcept C2779306644 @default.
• W2045707154 hasConcept C2780091579 @default.
• W2045707154 hasConcept C2781231759 @default.
• W2045707154 hasConcept C55493867 @default.
• W2045707154 hasConcept C555293320 @default.
• W2045707154 hasConcept C56906281 @default.
• W2045707154 hasConcept C71924100 @default.
• W2045707154 hasConcept C86803240 @default.
• W2045707154 hasConcept C90466245 @default.
• W2045707154 hasConceptScore W2045707154C126322002 @default.
• W2045707154 hasConceptScore W2045707154C134018914 @default.
• W2045707154 hasConceptScore W2045707154C2776543447 @default.
• W2045707154 hasConceptScore W2045707154C2777180221 @default.
• W2045707154 hasConceptScore W2045707154C2778305430 @default.
• W2045707154 hasConceptScore W2045707154C2779306644 @default.
• W2045707154 hasConceptScore W2045707154C2780091579 @default.
• W2045707154 hasConceptScore W2045707154C2781231759 @default.

• next