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- W2045716255 endingPage "11" @default.
- W2045716255 startingPage "4" @default.
- W2045716255 abstract "Schizophrenia is associated with abnormalities of hippocampal structure and function. Neuroimaging studies have shown that the hippocampus is hyperactive in schizophrenia. Here we explore GABAergic mechanisms of this hippocampal hyperactivity. The initial evidence for GABAergic abnormalities of the hippocampus in schizophrenia came from post-mortem studies of interneuron number, protein expression, and gene expression. These studies revealed marked decreases in gene and protein expression of somatostatin-positive and parvalbumin-positive interneurons, and indicated reduced interneuron numbers. Animal studies of decreased parvalbumin and NMDA-receptor function have shown that selective abnormalities of hippocampal interneurons mimic some of the cognitive deficits and clinical features of schizophrenia. The post-mortem and animal studies are consistent with the neuroimaging finding of increased hippocampal activity in schizophrenia, which can explain some of the psychotic symptoms and cognitive deficits. Taken together, these findings may guide the development of biomarkers and the development of new treatments for psychosis." @default.
- W2045716255 created "2016-06-24" @default.
- W2045716255 creator A5039198415 @default.
- W2045716255 creator A5053592141 @default.
- W2045716255 date "2015-09-01" @default.
- W2045716255 modified "2023-10-01" @default.
- W2045716255 title "GABAergic mechanisms of hippocampal hyperactivity in schizophrenia" @default.
- W2045716255 cites W1603307924 @default.
- W2045716255 cites W1867505698 @default.
- W2045716255 cites W1964043050 @default.
- W2045716255 cites W1966480770 @default.
- W2045716255 cites W1967324141 @default.
- W2045716255 cites W1968198840 @default.
- W2045716255 cites W1968591792 @default.
- W2045716255 cites W1968700646 @default.
- W2045716255 cites W1969273085 @default.
- W2045716255 cites W1972575403 @default.
- W2045716255 cites W1975453639 @default.
- W2045716255 cites W1975705681 @default.
- W2045716255 cites W1979612107 @default.
- W2045716255 cites W1981983302 @default.
- W2045716255 cites W1982518513 @default.
- W2045716255 cites W1984141645 @default.
- W2045716255 cites W1990880386 @default.
- W2045716255 cites W1991698797 @default.
- W2045716255 cites W1995221679 @default.
- W2045716255 cites W1995742542 @default.
- W2045716255 cites W2000628954 @default.
- W2045716255 cites W2001954021 @default.
- W2045716255 cites W2005115622 @default.
- W2045716255 cites W2008027377 @default.
- W2045716255 cites W2008268257 @default.
- W2045716255 cites W2009094679 @default.
- W2045716255 cites W2011345925 @default.
- W2045716255 cites W2011642725 @default.
- W2045716255 cites W2013209042 @default.
- W2045716255 cites W2013803050 @default.
- W2045716255 cites W2014540773 @default.
- W2045716255 cites W2016712906 @default.
- W2045716255 cites W2018281854 @default.
- W2045716255 cites W2022809683 @default.
- W2045716255 cites W2026802237 @default.
- W2045716255 cites W2029409685 @default.
- W2045716255 cites W2032520305 @default.
- W2045716255 cites W2038692754 @default.
- W2045716255 cites W2039747964 @default.
- W2045716255 cites W2046811219 @default.
- W2045716255 cites W2049723926 @default.
- W2045716255 cites W2057905701 @default.
- W2045716255 cites W2060137544 @default.
- W2045716255 cites W2060589548 @default.
- W2045716255 cites W2061902128 @default.
- W2045716255 cites W2061945050 @default.
- W2045716255 cites W2062329322 @default.
- W2045716255 cites W2064378998 @default.
- W2045716255 cites W2067274883 @default.
- W2045716255 cites W2068041800 @default.
- W2045716255 cites W2068181401 @default.
- W2045716255 cites W2071679295 @default.
- W2045716255 cites W2077656801 @default.
- W2045716255 cites W2078446073 @default.
- W2045716255 cites W2080700771 @default.
- W2045716255 cites W2082629072 @default.
- W2045716255 cites W2083419496 @default.
- W2045716255 cites W2084017889 @default.
- W2045716255 cites W2084615226 @default.
- W2045716255 cites W2088081549 @default.
- W2045716255 cites W2088315022 @default.
- W2045716255 cites W2089912569 @default.
- W2045716255 cites W2091679114 @default.
- W2045716255 cites W2094767250 @default.
- W2045716255 cites W2095060637 @default.
- W2045716255 cites W2096121563 @default.
- W2045716255 cites W2096542244 @default.
- W2045716255 cites W2097030222 @default.
- W2045716255 cites W2098205950 @default.
- W2045716255 cites W2103248466 @default.
- W2045716255 cites W2106077828 @default.
- W2045716255 cites W2113525305 @default.
- W2045716255 cites W2114502694 @default.
- W2045716255 cites W2116663526 @default.
- W2045716255 cites W2133267973 @default.
- W2045716255 cites W2137547644 @default.
- W2045716255 cites W2141704087 @default.
- W2045716255 cites W2149983435 @default.
- W2045716255 cites W2152958283 @default.
- W2045716255 cites W2153185503 @default.
- W2045716255 cites W2156123885 @default.
- W2045716255 cites W2161851141 @default.
- W2045716255 cites W2163538276 @default.
- W2045716255 cites W2165075766 @default.
- W2045716255 cites W2166330737 @default.
- W2045716255 cites W2166364179 @default.
- W2045716255 cites W2168187353 @default.
- W2045716255 cites W2168312889 @default.
- W2045716255 cites W2169365717 @default.
- W2045716255 cites W2171854040 @default.
- W2045716255 cites W2320983896 @default.