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• W2045718085 abstract "The aim of this study was to examine the effects of LY117018, a selective estrogen receptor modulator, on peripheral nerve regeneration, using a model of sciatic nerve crush injury in mice. Sciatic functional index, an index of functional recovery, was significantly higher in LY117018 treated mice throughout regeneration. Analysis of semi-thin sections revealed a significant increase in both the total number of regenerating nerve fibers at day 7, and the mean axonal area of myelinated fibers at 7, 14, and 21 days after injury, in LY117018 treated mice. Analysis of axonal transport through retrograde labeling of motor neurons showed that LY117018 increased transport, and ICI 182,780 blocked the effects of LY117018, delineating estrogen receptors as its target. Our study suggests that LY117018 may markedly accelerate peripheral nerve regeneration and functional recovery through activation of estrogen receptors." @default.
• W2045718085 created "2016-06-24" @default.
• W2045718085 creator A5014118365 @default.
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• W2045718085 date "2003-08-01" @default.
• W2045718085 modified "2023-10-07" @default.
• W2045718085 title "Raloxifene analog LY117018 enhances the regeneration of sciatic nerve in ovariectomized female mice" @default.
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• W2045718085 doi "https://doi.org/10.1016/s0006-8993(03)02984-6" @default.
• W2045718085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12865169" @default.
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