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- W2045733067 abstract "For 13 weeks, groups of C57Bl6J male mice were exposed to 300 ppm benzene by inhalation, 6 hr/day, 5 days/week, and to 5 or 15% ethanol in the drinking water, 4 days/week. The number and type of blood cells in the peripheral blood, marrow, and spleen were determined at regular intervals. Anemia and lymphocytopenia were observed in the peripheral blood of all benzene and benzene/ethanol-treated groups. These cytopenias, however, were more severe in the benzene/ethanol-treated mice. In addition, there was a transient increase of normoblasts in the peripheral blood of benzene/ethanol-treated mice which was not observed in mice treated with benzene alone or in control mice. Groups exposed to benzene or benzene/ethanol displayed reduced marrow and splenic cellularities but the reductions were more severe in mice exposed to benzene/ethanol. Specifically, these reduced cellularities were characterized by decreased numbers of lymphocytes in both marrow and spleen and decreased numbers of granulocytes and normoblasts in the marrow. In benzene/ethanol-treated mice a transient increase in the numbers of splenic normoblasts was observed which coincided with the transient appearance of normoblasts in the peripheral blood of these animals. This condition was not observed in mice treated with only benzene or only ethanol. Mice exposed to benzene/ethanol presented a greater degree of atypical cellular morphology than mice treated with benzene alone. These data suggest that the ingestion of ethanol increases the hematotoxicity of inhaled benzene." @default.
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- W2045733067 date "1982-07-01" @default.
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- W2045733067 title "The hematotoxic effects of inhaled benzene on peripheral blood, bone marrow, and spleen cells are increased by ingested ethanol" @default.
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- W2045733067 doi "https://doi.org/10.1016/0041-008x(82)90235-6" @default.
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