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• W2045735041 abstract "Positron emission tomography (PET) using [(11)C]PK 11195, a ligand for peripheral benzodiazepine receptor binding sites, offers the opportunity to image activated microglia in vivo. This tool may therefore be used to display the occurrence of microglial activation in the course of neurodegeneration. A patient with the clinical diagnosis of corticobasal degeneration (CBD) and left-sided symptoms was studied using fluorodeoxyglucose (FDG) and [(11)C]PK 11195 PET. We found a marked right hemispheric hypometabolism and asymmetric microglial activation in corresponding areas of the basal ganglia and right temporal and parietal cortex. [(11)C]PK 11195 PET suggests involvement of microglial activation in the pathogenesis of CBD." @default.
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• W2045735041 date "2004-03-04" @default.
• W2045735041 modified "2023-09-29" @default.
• W2045735041 title "Imaging of activated microglia with PET and [¹¹ C]PK 11195 in corticobasal degeneration" @default.
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• W2045735041 doi "https://doi.org/10.1002/mds.20040" @default.
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