Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045739608> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2045739608 endingPage "406" @default.
- W2045739608 startingPage "395" @default.
- W2045739608 abstract "Effect of epinephrine on α-methyl-D-glucopyranoside uptake in renal proximal tubule cells. Epinephrine has known to be a very important factor in the regulation of renal sodium excretion. However, the effect of epinephrine on Na+/glucose cotransporter was not fully elucidated. Thus, we examined effect of epinephrine on α-methyl-D-glucopyranoside (α-MG) uptake and its related signal pathways in the primary cultured rabbit renal proximal tubule cells (PTCs). Epinephrine inhibited α-MG uptake in a time- and dose-dependent manner and also decreased SGLT1 and SGLT2 protein level. Both phentolamine and propranolol completely prevented epinephrine-induced inhibition of α-MG uptake. The epinephrine-induced inhibition of α-MG uptake was blocked by SQ-22536 or myristoylated PKA inhibitor amide 14-22 and epinephrine increased the intracellular cAMP content. In western blotting analysis, epinephrine increases phosphorylation of p44/42 and p38 MAPKs and PD 98059 or SB 203580 blocked the effect of epinephrine. In addition, epinephrine increased AA release and PGE2 production and effects of epinephrine on α-MG uptake and AA release were blocked by staurosporine and bisindolylmaleimide I or mepacrine and AACOCF3. Indeed, epinephrine translocated PKC or cPLA2 from cytosol to membrane fraction. In conclusion, epinephrine partially inhibits the α-MG uptake through PKA, PKC, p44/42, p38 MAPK, and cPLA2 pathways in the PTCs." @default.
- W2045739608 created "2016-06-24" @default.
- W2045739608 creator A5022918002 @default.
- W2045739608 creator A5030401664 @default.
- W2045739608 creator A5038375061 @default.
- W2045739608 creator A5088229898 @default.
- W2045739608 date "2004-01-01" @default.
- W2045739608 modified "2023-09-30" @default.
- W2045739608 title "Effect of Epinephrine on α-Methyl-D-Glucopyranoside Uptake in Renal Proximal Tubule Cells" @default.
- W2045739608 cites W1517887854 @default.
- W2045739608 cites W1581760931 @default.
- W2045739608 cites W1905908978 @default.
- W2045739608 cites W1956777900 @default.
- W2045739608 cites W1967385667 @default.
- W2045739608 cites W1979995843 @default.
- W2045739608 cites W1994821631 @default.
- W2045739608 cites W2002859649 @default.
- W2045739608 cites W2003082471 @default.
- W2045739608 cites W2021488471 @default.
- W2045739608 cites W2031913497 @default.
- W2045739608 cites W2052432397 @default.
- W2045739608 cites W2062077365 @default.
- W2045739608 cites W2064780286 @default.
- W2045739608 cites W2065327374 @default.
- W2045739608 cites W2077257042 @default.
- W2045739608 cites W2077284332 @default.
- W2045739608 cites W2128635872 @default.
- W2045739608 cites W2129695314 @default.
- W2045739608 cites W2131209789 @default.
- W2045739608 cites W2151879921 @default.
- W2045739608 cites W2152211669 @default.
- W2045739608 cites W2163343460 @default.
- W2045739608 cites W2179914469 @default.
- W2045739608 cites W2298525613 @default.
- W2045739608 cites W2316287242 @default.
- W2045739608 cites W2327810040 @default.
- W2045739608 cites W2338392999 @default.
- W2045739608 cites W2410771120 @default.
- W2045739608 cites W55567811 @default.
- W2045739608 doi "https://doi.org/10.1159/000080349" @default.
- W2045739608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15319543" @default.
- W2045739608 hasPublicationYear "2004" @default.
- W2045739608 type Work @default.
- W2045739608 sameAs 2045739608 @default.
- W2045739608 citedByCount "8" @default.
- W2045739608 countsByYear W20457396082015 @default.
- W2045739608 countsByYear W20457396082016 @default.
- W2045739608 countsByYear W20457396082017 @default.
- W2045739608 countsByYear W20457396082020 @default.
- W2045739608 crossrefType "journal-article" @default.
- W2045739608 hasAuthorship W2045739608A5022918002 @default.
- W2045739608 hasAuthorship W2045739608A5030401664 @default.
- W2045739608 hasAuthorship W2045739608A5038375061 @default.
- W2045739608 hasAuthorship W2045739608A5088229898 @default.
- W2045739608 hasConcept C11960822 @default.
- W2045739608 hasConcept C126322002 @default.
- W2045739608 hasConcept C134018914 @default.
- W2045739608 hasConcept C185592680 @default.
- W2045739608 hasConcept C195794163 @default.
- W2045739608 hasConcept C2775859304 @default.
- W2045739608 hasConcept C55493867 @default.
- W2045739608 hasConcept C71924100 @default.
- W2045739608 hasConceptScore W2045739608C11960822 @default.
- W2045739608 hasConceptScore W2045739608C126322002 @default.
- W2045739608 hasConceptScore W2045739608C134018914 @default.
- W2045739608 hasConceptScore W2045739608C185592680 @default.
- W2045739608 hasConceptScore W2045739608C195794163 @default.
- W2045739608 hasConceptScore W2045739608C2775859304 @default.
- W2045739608 hasConceptScore W2045739608C55493867 @default.
- W2045739608 hasConceptScore W2045739608C71924100 @default.
- W2045739608 hasIssue "4-6" @default.
- W2045739608 hasLocation W20457396081 @default.
- W2045739608 hasLocation W20457396082 @default.
- W2045739608 hasOpenAccess W2045739608 @default.
- W2045739608 hasPrimaryLocation W20457396081 @default.
- W2045739608 hasRelatedWork W1974684692 @default.
- W2045739608 hasRelatedWork W1992637805 @default.
- W2045739608 hasRelatedWork W2004449713 @default.
- W2045739608 hasRelatedWork W2026413826 @default.
- W2045739608 hasRelatedWork W2038512896 @default.
- W2045739608 hasRelatedWork W2044985824 @default.
- W2045739608 hasRelatedWork W2054777415 @default.
- W2045739608 hasRelatedWork W2083737357 @default.
- W2045739608 hasRelatedWork W2460584456 @default.
- W2045739608 hasRelatedWork W4234517484 @default.
- W2045739608 hasVolume "14" @default.
- W2045739608 isParatext "false" @default.
- W2045739608 isRetracted "false" @default.
- W2045739608 magId "2045739608" @default.
- W2045739608 workType "article" @default.