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- W2045744218 abstract "Astrocytes are coupled to each other via gap-junctions both in vivo and in vitro. Gap-junction coupling is essential to a number of astrocyte functions including the spatial buffering of extracellular K+ and the propagation of Ca2+ waves. Using fluorescence recovery after photo-bleach, we quantitatively assayed and compared the coupling of astrocytes cultured from six different central nervous system (CNS) regions in the rat: spinal cord, cortex, hypothalamus, hippocampus, optic nerve, and cerebellum. The degree of fluorescence recovery (% recovery) and time constant of recovery (∼) served as quantitative indicators of coupling strength. Gap-junction coupling differed markedly between CNS regions. Coupling was weakest in astrocytes derived from spinal cord (43% recovery, τ∼400 s) and strongest in astrocytes from optic nerve (91% recovery, τ∼226 s) and cerebellum (95% recovery, τ∼100 s). As indicated by the degree of recovery, coupling strength among CNS regions could be ranked as follows: spinal cord < cortex < hypothalamus < hippocampus = optic nerve = cerebellum. Gap-junction coupling also differed between CNS regions with respect to its sensitivity to inhibition by the uncoupling agent octanol. Kd values for 50% inhibition by octanol ranged from 188 μM in spinal cord astrocytes to 654 μM in hippocampal astrocytes. Sensitivity of gap-junctions to octanol could be ranked as follows: spinal cord = cortex = hypothalamus> cerebellum> optic nerve> hippocampus. The observed differences in coupling indicate differences in the number of gap-junction connections in astrocytes cultured from the six CNS regions. These differences may reflect the adaptation of astrocytes to varying functional requirements in different CNS regions. © 1994 Wiley-Liss, Inc." @default.
- W2045744218 created "2016-06-24" @default.
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- W2045744218 date "1994-08-01" @default.
- W2045744218 modified "2023-10-16" @default.
- W2045744218 title "Astrocytes exhibit regional specificity in gap-junction coupling" @default.
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- W2045744218 doi "https://doi.org/10.1002/glia.440110404" @default.
- W2045744218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7960035" @default.
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