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- W2045748035 abstract "L-carnitine (LC), which is essential for fat utilization, acts by facilitating long chain fatty acid transport into the mitochondrial matrix where B-oxidation occurs. The purpose of this prospective study was to determine if LC supplementation given to carnitine deficient infants would results in improved utilization of exogenously administered IV fat. Seventeen infants (gestational age 35.8±3.7 wks, postnatal age 13.6±7.3 wks, weight 3.3±1.0 kg) requiring a minimum of 7 days of parenteral nutrition (PN) and able to tolerate small quantities of enteral feedings were randomized into treatment and control groups. All infants had received nutritional support devoid of LC. Plasma carnitine (PC) levels did not vary significantly between groups in the pre-study period (control: 10.0±6.3 nM/ml; treatment: 9.4±6.0 nM/ml). Infants received 7 days of continuous nasogastric or gastric tube LC (50uM/k/d) or placebo. Fat was withheld and glucose reduced to 10% for 16 hrs prior to the delivery of a 0.5 gm/k IntralipidR bolus administered over 2 hrs. LC supplementation continued until termination of the fat bolus. Serial blood samples for triglycerides (TGY), free fatty acids (FFA), acetoacetate (AA), B-hydroxybutyrate (BOB) and PC were observed at 0 (start of lipid infusion), 2,4,6 and 8 hrs. Infants receiving carnitine had significantly greater (p<0.05) concentrations of BOB, total ketones (BOB plus AA), and PC at times 0,2,4,6 and 8 hrs when compared to controls. Significantly lower (p<0.05) FFA/BOB ratios were observed in the treatment group at 2 and 4 hours indicating improved ketogenesis. No significant differences were found between groups for TGY or FFA at any observation period. This study demonstrated improved fatty acid oxidation as evidenced by increased ketogenesis with LC supplementation in carnitine deficient infants." @default.
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- W2045748035 date "1985-04-01" @default.
- W2045748035 modified "2023-09-27" @default.
- W2045748035 title "667 L-CARNITINE ON FAT UTILIZATION IN INFANTS" @default.
- W2045748035 doi "https://doi.org/10.1203/00006450-198504000-00697" @default.
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