Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045751610> ?p ?o ?g. }
- W2045751610 endingPage "417" @default.
- W2045751610 startingPage "412" @default.
- W2045751610 abstract "A series of phenolic and saponin type natural products such as quercetin, rutin, catechin, epicatechin, silymarin, trojanoside H, astragaloside IV, astragaloside VIII and astrasieversianin X, were investigated for their inhibitory effects against the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1). We here report inhibitory effects of these compounds against five α-CA isozymes (hCA I, hCA II, bCA III, hCA IV and hCA VI). Most of the phenolic and saponin type compounds inhibited the isoenzymes quite effectively at low micromolar KI-s ranging between 0.1 and 4 µM, whereas a few derivatives were ineffective (KI-s > 100 µM). The results were remarkable which might lead to design of novel CAIs with a diverse inhibition mechanism compared to sulfonamide/sulfamate inhibitors." @default.
- W2045751610 created "2016-06-24" @default.
- W2045751610 creator A5021780004 @default.
- W2045751610 creator A5027937388 @default.
- W2045751610 creator A5031670725 @default.
- W2045751610 creator A5035013697 @default.
- W2045751610 creator A5054227054 @default.
- W2045751610 creator A5062813235 @default.
- W2045751610 creator A5072423904 @default.
- W2045751610 date "2012-02-03" @default.
- W2045751610 modified "2023-10-18" @default.
- W2045751610 title "Analysis of saponins and phenolic compounds as inhibitors of α-carbonic anhydrase isoenzymes" @default.
- W2045751610 cites W1484418190 @default.
- W2045751610 cites W1484765693 @default.
- W2045751610 cites W1513087030 @default.
- W2045751610 cites W1582920403 @default.
- W2045751610 cites W1586150986 @default.
- W2045751610 cites W1814763565 @default.
- W2045751610 cites W1895941201 @default.
- W2045751610 cites W1966700699 @default.
- W2045751610 cites W1969694148 @default.
- W2045751610 cites W1970221679 @default.
- W2045751610 cites W1972953685 @default.
- W2045751610 cites W1975354197 @default.
- W2045751610 cites W1976584967 @default.
- W2045751610 cites W1997861767 @default.
- W2045751610 cites W2003757254 @default.
- W2045751610 cites W2005115278 @default.
- W2045751610 cites W2019636225 @default.
- W2045751610 cites W2020138081 @default.
- W2045751610 cites W2020880561 @default.
- W2045751610 cites W2022538143 @default.
- W2045751610 cites W2025001185 @default.
- W2045751610 cites W2030917579 @default.
- W2045751610 cites W2046629801 @default.
- W2045751610 cites W2047178318 @default.
- W2045751610 cites W2048684439 @default.
- W2045751610 cites W2051349300 @default.
- W2045751610 cites W2054979333 @default.
- W2045751610 cites W2059530081 @default.
- W2045751610 cites W2061459802 @default.
- W2045751610 cites W2068444439 @default.
- W2045751610 cites W2072317677 @default.
- W2045751610 cites W2084330715 @default.
- W2045751610 cites W2100788797 @default.
- W2045751610 cites W2100837269 @default.
- W2045751610 cites W2110095679 @default.
- W2045751610 cites W2110834084 @default.
- W2045751610 cites W2117701880 @default.
- W2045751610 cites W2123893953 @default.
- W2045751610 cites W2125916691 @default.
- W2045751610 cites W2134009516 @default.
- W2045751610 cites W2146370713 @default.
- W2045751610 cites W2151573674 @default.
- W2045751610 cites W2152925174 @default.
- W2045751610 cites W2153237991 @default.
- W2045751610 cites W2164451594 @default.
- W2045751610 cites W2397681412 @default.
- W2045751610 cites W4293247451 @default.
- W2045751610 doi "https://doi.org/10.3109/14756366.2011.651464" @default.
- W2045751610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22299585" @default.
- W2045751610 hasPublicationYear "2012" @default.
- W2045751610 type Work @default.
- W2045751610 sameAs 2045751610 @default.
- W2045751610 citedByCount "49" @default.
- W2045751610 countsByYear W20457516102014 @default.
- W2045751610 countsByYear W20457516102015 @default.
- W2045751610 countsByYear W20457516102016 @default.
- W2045751610 countsByYear W20457516102017 @default.
- W2045751610 countsByYear W20457516102018 @default.
- W2045751610 countsByYear W20457516102022 @default.
- W2045751610 countsByYear W20457516102023 @default.
- W2045751610 crossrefType "journal-article" @default.
- W2045751610 hasAuthorship W2045751610A5021780004 @default.
- W2045751610 hasAuthorship W2045751610A5027937388 @default.
- W2045751610 hasAuthorship W2045751610A5031670725 @default.
- W2045751610 hasAuthorship W2045751610A5035013697 @default.
- W2045751610 hasAuthorship W2045751610A5054227054 @default.
- W2045751610 hasAuthorship W2045751610A5062813235 @default.
- W2045751610 hasAuthorship W2045751610A5072423904 @default.
- W2045751610 hasConcept C119795356 @default.
- W2045751610 hasConcept C142724271 @default.
- W2045751610 hasConcept C181199279 @default.
- W2045751610 hasConcept C185592680 @default.
- W2045751610 hasConcept C194671627 @default.
- W2045751610 hasConcept C204787440 @default.
- W2045751610 hasConcept C2775914622 @default.
- W2045751610 hasConcept C2775963812 @default.
- W2045751610 hasConcept C2778004101 @default.
- W2045751610 hasConcept C2778564307 @default.
- W2045751610 hasConcept C2779431889 @default.
- W2045751610 hasConcept C2781263971 @default.
- W2045751610 hasConcept C2911210155 @default.
- W2045751610 hasConcept C55493867 @default.
- W2045751610 hasConcept C70899900 @default.
- W2045751610 hasConcept C71240020 @default.
- W2045751610 hasConcept C71924100 @default.
- W2045751610 hasConceptScore W2045751610C119795356 @default.