Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045751715> ?p ?o ?g. }
- W2045751715 endingPage "e57343" @default.
- W2045751715 startingPage "e57343" @default.
- W2045751715 abstract "SerpinB2, also known as plasminogen activator inhibitor type 2, is a major product of activated monocytes/macrophages and is often strongly induced during infection and inflammation; however, its physiological function remains somewhat elusive. Herein we show that SerpinB2 is induced in peripheral blood mononuclear cells following infection of pigtail macaques with CCR5-utilizing (macrophage-tropic) SIVmac239, but not the rapidly pathogenic CXCR4-utilizing (T cell-tropic) SHIVmn229. To investigate the role of SerpinB2 in lentiviral infections, SerpinB2−/− mice were infected with EcoHIV, a chimeric HIV in which HIV gp120 has been replaced with gp80 from ecotropic murine leukemia virus. EcoHIV infected SerpinB2−/− mice produced significantly lower anti-gag IgG1 antibody titres than infected SerpinB2+/+ mice, and showed slightly delayed clearance of EcoHIV. Analyses of published microarray studies showed significantly higher levels of SerpinB2 mRNA in monocytes from HIV-1 infected patients when compared with uninfected controls, as well as a significant negative correlation between SerpinB2 and T-bet mRNA levels in peripheral blood mononuclear cells. These data illustrate that SerpinB2 can be induced by lentiviral infection in vivo and support the emerging notion that a physiological role of SerpinB2 is modulation of Th1/Th2 responses." @default.
- W2045751715 created "2016-06-24" @default.
- W2045751715 creator A5042529968 @default.
- W2045751715 creator A5044357590 @default.
- W2045751715 creator A5054025307 @default.
- W2045751715 creator A5054161088 @default.
- W2045751715 creator A5060344821 @default.
- W2045751715 creator A5072313662 @default.
- W2045751715 creator A5088371247 @default.
- W2045751715 date "2013-02-27" @default.
- W2045751715 modified "2023-10-16" @default.
- W2045751715 title "Induction of SerpinB2 and Th1/Th2 Modulation by SerpinB2 during Lentiviral Infections In Vivo" @default.
- W2045751715 cites W1507606456 @default.
- W2045751715 cites W1810346478 @default.
- W2045751715 cites W1853829787 @default.
- W2045751715 cites W1904478869 @default.
- W2045751715 cites W1965534188 @default.
- W2045751715 cites W1968849783 @default.
- W2045751715 cites W1970871735 @default.
- W2045751715 cites W1971681498 @default.
- W2045751715 cites W1976344112 @default.
- W2045751715 cites W1978564615 @default.
- W2045751715 cites W1981894924 @default.
- W2045751715 cites W1983506772 @default.
- W2045751715 cites W1985777588 @default.
- W2045751715 cites W1988723911 @default.
- W2045751715 cites W1997148405 @default.
- W2045751715 cites W2001339252 @default.
- W2045751715 cites W2019948808 @default.
- W2045751715 cites W2020565084 @default.
- W2045751715 cites W2020657448 @default.
- W2045751715 cites W2027575466 @default.
- W2045751715 cites W2027809408 @default.
- W2045751715 cites W2033693429 @default.
- W2045751715 cites W2038437746 @default.
- W2045751715 cites W2040226659 @default.
- W2045751715 cites W2040821036 @default.
- W2045751715 cites W2048914340 @default.
- W2045751715 cites W2049491060 @default.
- W2045751715 cites W2055089534 @default.
- W2045751715 cites W2061687327 @default.
- W2045751715 cites W2068880841 @default.
- W2045751715 cites W2072022570 @default.
- W2045751715 cites W2085121629 @default.
- W2045751715 cites W2093514748 @default.
- W2045751715 cites W2099536121 @default.
- W2045751715 cites W2102186747 @default.
- W2045751715 cites W2111226878 @default.
- W2045751715 cites W2123213735 @default.
- W2045751715 cites W2133045932 @default.
- W2045751715 cites W2133968571 @default.
- W2045751715 cites W2134565574 @default.
- W2045751715 cites W2139119391 @default.
- W2045751715 cites W2139270639 @default.
- W2045751715 cites W2140066111 @default.
- W2045751715 cites W2143597049 @default.
- W2045751715 cites W2145848202 @default.
- W2045751715 cites W2156014983 @default.
- W2045751715 cites W2158240501 @default.
- W2045751715 cites W2158934960 @default.
- W2045751715 cites W2171136144 @default.
- W2045751715 cites W2278969192 @default.
- W2045751715 doi "https://doi.org/10.1371/journal.pone.0057343" @default.
- W2045751715 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3583835" @default.
- W2045751715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23460840" @default.
- W2045751715 hasPublicationYear "2013" @default.
- W2045751715 type Work @default.
- W2045751715 sameAs 2045751715 @default.
- W2045751715 citedByCount "13" @default.
- W2045751715 countsByYear W20457517152013 @default.
- W2045751715 countsByYear W20457517152014 @default.
- W2045751715 countsByYear W20457517152016 @default.
- W2045751715 countsByYear W20457517152018 @default.
- W2045751715 countsByYear W20457517152019 @default.
- W2045751715 countsByYear W20457517152021 @default.
- W2045751715 countsByYear W20457517152022 @default.
- W2045751715 crossrefType "journal-article" @default.
- W2045751715 hasAuthorship W2045751715A5042529968 @default.
- W2045751715 hasAuthorship W2045751715A5044357590 @default.
- W2045751715 hasAuthorship W2045751715A5054025307 @default.
- W2045751715 hasAuthorship W2045751715A5054161088 @default.
- W2045751715 hasAuthorship W2045751715A5060344821 @default.
- W2045751715 hasAuthorship W2045751715A5072313662 @default.
- W2045751715 hasAuthorship W2045751715A5088371247 @default.
- W2045751715 hasBestOaLocation W20457517151 @default.
- W2045751715 hasConcept C137061746 @default.
- W2045751715 hasConcept C150903083 @default.
- W2045751715 hasConcept C159047783 @default.
- W2045751715 hasConcept C202751555 @default.
- W2045751715 hasConcept C203014093 @default.
- W2045751715 hasConcept C207001950 @default.
- W2045751715 hasConcept C26291073 @default.
- W2045751715 hasConcept C55493867 @default.
- W2045751715 hasConcept C86803240 @default.
- W2045751715 hasConceptScore W2045751715C137061746 @default.
- W2045751715 hasConceptScore W2045751715C150903083 @default.
- W2045751715 hasConceptScore W2045751715C159047783 @default.
- W2045751715 hasConceptScore W2045751715C202751555 @default.