FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045751750> ?p ?o ?g. }

• W2045751750 endingPage "250" @default.
• W2045751750 startingPage "244" @default.
• W2045751750 abstract "beta-Carotene and other carotenoids are widely regarded as biological antioxidants. However, recent clinical trials indicate that beta-carotene supplements are not effective in disease prevention and raise questions about the biological significance of carotenoid antioxidant actions. To further explore this issue, we have reevaluated the antioxidant actions of beta-carotene in liposomal and biological membrane systems. In dilinoleoylphosphatidylcholine liposomes in which 0.35 mol % beta-carotene was incorporated into the bilayer during liposome preparation, the carotenoid inhibited lipid peroxidation initiated by 10 mm azobis[amidinopropane HCl] (AAPH). In carotenoid-free liposome suspensions to which the same amount of beta-carotene was added, no antioxidant effect was observed. Supplementation of rat liver microsomes with beta-carotene in vitro yielded microsomes containing 1.7 nmol beta-carotene mg-1 and 0.16 nmol alpha-tocopherol mg-1 microsomal protein. In beta-carotene supplemented microsomes incubated with 10 mm AAPH under an air atmosphere, lipid peroxidation did not occur until alpha-tocopherol was depleted by approximately 60%. beta-Carotene exerted no apparent antioxidant effect and was not significantly depleted in the incubations. Similar results were obtained when the incubation was done at 3.8 torr O2. In liver microsomes from Mongolian gerbils fed beta-carotene-supplemented diets, beta-carotene levels were 16-37% of alpha-tocopherol levels. The kinetics of AAPH-induced lipid peroxidation were no different in beta-carotene-supplemented microsomes than in microsomes from unsupplemented animals, although the kinetics of beta-carotene and alpha-tocopherol depletion were similar. The results indicate that beta-carotene is ineffective as an antioxidant when added to preformed lipid bilayer membranes and that alpha-tocopherol is a much more effective membrane antioxidant than beta-carotene, regardless of the method of carotenoid-membrane incorporation. These results support a reevaluation of the proposed antioxidant role for beta-carotene in biological membranes." @default.
• W2045751750 created "2016-06-24" @default.
• W2045751750 creator A5073863316 @default.
• W2045751750 creator A5076297382 @default.
• W2045751750 creator A5080156761 @default.
• W2045751750 date "1997-02-01" @default.
• W2045751750 modified "2023-09-26" @default.
• W2045751750 title "Antioxidant Actions of β-Carotene in Liposomal and Microsomal Membranes: Role of Carotenoid-Membrane Incorporation and α-Tocopherol" @default.
• W2045751750 cites W1525444530 @default.
• W2045751750 cites W1539630105 @default.
• W2045751750 cites W1545350562 @default.
• W2045751750 cites W1550759179 @default.
• W2045751750 cites W1590457525 @default.
• W2045751750 cites W18409891 @default.
• W2045751750 cites W1910739335 @default.
• W2045751750 cites W1966582616 @default.
• W2045751750 cites W1966938679 @default.
• W2045751750 cites W1969444861 @default.
• W2045751750 cites W1975045923 @default.
• W2045751750 cites W1981264042 @default.
• W2045751750 cites W1982704132 @default.
• W2045751750 cites W1999574232 @default.
• W2045751750 cites W2002839475 @default.
• W2045751750 cites W2032529891 @default.
• W2045751750 cites W2033243284 @default.
• W2045751750 cites W2033624890 @default.
• W2045751750 cites W2039784245 @default.
• W2045751750 cites W2046832043 @default.
• W2045751750 cites W2058523499 @default.
• W2045751750 cites W2067152228 @default.
• W2045751750 cites W2068103674 @default.
• W2045751750 cites W2085073989 @default.
• W2045751750 cites W2095986115 @default.
• W2045751750 cites W2104804666 @default.
• W2045751750 cites W217686281 @default.
• W2045751750 cites W2177001075 @default.
• W2045751750 cites W2197620669 @default.
• W2045751750 cites W2315403385 @default.
• W2045751750 cites W2317242858 @default.
• W2045751750 cites W2317479712 @default.
• W2045751750 doi "https://doi.org/10.1006/abbi.1996.9822" @default.
• W2045751750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9028879" @default.
• W2045751750 hasPublicationYear "1997" @default.
• W2045751750 type Work @default.
• W2045751750 sameAs 2045751750 @default.
• W2045751750 citedByCount "75" @default.
• W2045751750 countsByYear W20457517502012 @default.
• W2045751750 countsByYear W20457517502013 @default.
• W2045751750 countsByYear W20457517502015 @default.
• W2045751750 countsByYear W20457517502016 @default.
• W2045751750 countsByYear W20457517502019 @default.
• W2045751750 countsByYear W20457517502020 @default.
• W2045751750 countsByYear W20457517502021 @default.
• W2045751750 countsByYear W20457517502022 @default.
• W2045751750 crossrefType "journal-article" @default.
• W2045751750 hasAuthorship W2045751750A5073863316 @default.
• W2045751750 hasAuthorship W2045751750A5076297382 @default.
• W2045751750 hasAuthorship W2045751750A5080156761 @default.
• W2045751750 hasConcept C185154212 @default.
• W2045751750 hasConcept C185592680 @default.
• W2045751750 hasConcept C202751555 @default.
• W2045751750 hasConcept C2776524530 @default.
• W2045751750 hasConcept C2776998673 @default.
• W2045751750 hasConcept C2777551382 @default.
• W2045751750 hasConcept C2778004101 @default.
• W2045751750 hasConcept C2778859900 @default.
• W2045751750 hasConcept C2780829032 @default.
• W2045751750 hasConcept C2781449162 @default.
• W2045751750 hasConcept C28781525 @default.
• W2045751750 hasConcept C31903555 @default.
• W2045751750 hasConcept C55493867 @default.
• W2045751750 hasConcept C87644729 @default.
• W2045751750 hasConceptScore W2045751750C185154212 @default.
• W2045751750 hasConceptScore W2045751750C185592680 @default.
• W2045751750 hasConceptScore W2045751750C202751555 @default.
• W2045751750 hasConceptScore W2045751750C2776524530 @default.
• W2045751750 hasConceptScore W2045751750C2776998673 @default.
• W2045751750 hasConceptScore W2045751750C2777551382 @default.
• W2045751750 hasConceptScore W2045751750C2778004101 @default.
• W2045751750 hasConceptScore W2045751750C2778859900 @default.
• W2045751750 hasConceptScore W2045751750C2780829032 @default.
• W2045751750 hasConceptScore W2045751750C2781449162 @default.
• W2045751750 hasConceptScore W2045751750C28781525 @default.
• W2045751750 hasConceptScore W2045751750C31903555 @default.
• W2045751750 hasConceptScore W2045751750C55493867 @default.
• W2045751750 hasConceptScore W2045751750C87644729 @default.
• W2045751750 hasIssue "2" @default.
• W2045751750 hasLocation W20457517501 @default.
• W2045751750 hasLocation W20457517502 @default.
• W2045751750 hasOpenAccess W2045751750 @default.
• W2045751750 hasPrimaryLocation W20457517501 @default.
• W2045751750 hasRelatedWork W1977912696 @default.
• W2045751750 hasRelatedWork W2016219609 @default.
• W2045751750 hasRelatedWork W2029386460 @default.
• W2045751750 hasRelatedWork W2045751750 @default.
• W2045751750 hasRelatedWork W2049360061 @default.
• W2045751750 hasRelatedWork W2058523499 @default.
• W2045751750 hasRelatedWork W2082597224 @default.

• next