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• W2045751930 endingPage "33" @default.
• W2045751930 startingPage "1" @default.
• W2045751930 abstract "Ku is a heterodimeric protein composed of approximately 70- and approximately 80-kDa subunits (Ku70 and Ku80) originally identified as an autoantigen recognized by the sera of patients with autoimmune diseases. Ku has high binding affinity for DNA ends and that is why originally it was known as a DNA end binding protein, but now it is known to also bind the DNA structure at nicks, gaps, hairpins, as well as the ends of telomeres. It has been reported also to bind with sequence specificity to DNA and with weak affinity to RNA. Ku is an abundant nuclear protein and is present in vertebrates, insects, yeast, and worms. Ku contains ssDNA-dependent ATPase and ATP-dependent DNA helicase activities. It is the regulatory subunit of the DNA-dependent protein kinase that phosphorylates many proteins, including SV-40 large T antigen, p53, RNA-polymerase II, RP-A, topoisomerases, hsp90, and many transcription factors such as c-Jun, c-Fos, oct-1, sp-1, c-Myc, TFIID, and many more. It seems to be a multifunctional protein that has been implicated to be involved directly or indirectly in many important cellular metabolic processes such as DNA double-strand break repair, V(D)J recombination of immunoglobulins and T-cell receptor genes, immunoglobulin isotype switching, DNA replication, transcription regulation, regulation of heat shock-induced responses, regulation of the precise structure of telomeric termini, and it also plays a novel role in G2 and M phases of the cell cycle. The mechanism underlying the regulation of all the diverse functions of Ku is still obscure." @default.
• W2045751930 created "2016-06-24" @default.
• W2045751930 creator A5023350983 @default.
• W2045751930 creator A5026558664 @default.
• W2045751930 date "2000-01-01" @default.
• W2045751930 modified "2023-09-24" @default.
• W2045751930 title "Ku Autoantigen: A Multifunctional DNA-Binding Protein" @default.
• W2045751930 cites W1485243937 @default.
• W2045751930 cites W1501558639 @default.
• W2045751930 cites W1504854614 @default.
• W2045751930 cites W1506926943 @default.
• W2045751930 cites W1509547277 @default.
• W2045751930 cites W1516845708 @default.
• W2045751930 cites W1520268659 @default.
• W2045751930 cites W1526997346 @default.
• W2045751930 cites W1533085584 @default.
• W2045751930 cites W1533411509 @default.
• W2045751930 cites W1536050266 @default.
• W2045751930 cites W1536757970 @default.
• W2045751930 cites W1541786399 @default.
• W2045751930 cites W1543815058 @default.
• W2045751930 cites W1550569484 @default.
• W2045751930 cites W1557335706 @default.
• W2045751930 cites W1557970645 @default.
• W2045751930 cites W1566257366 @default.
• W2045751930 cites W1574557307 @default.
• W2045751930 cites W1584964960 @default.
• W2045751930 cites W1593571952 @default.
• W2045751930 cites W1601999342 @default.
• W2045751930 cites W1679815585 @default.
• W2045751930 cites W179381085 @default.
• W2045751930 cites W1809586716 @default.
• W2045751930 cites W1827719343 @default.
• W2045751930 cites W1888083613 @default.
• W2045751930 cites W1892185927 @default.
• W2045751930 cites W1907438453 @default.
• W2045751930 cites W1942599177 @default.
• W2045751930 cites W1959049775 @default.
• W2045751930 cites W1964252359 @default.
• W2045751930 cites W1964298731 @default.
• W2045751930 cites W1970232857 @default.
• W2045751930 cites W1970254580 @default.
• W2045751930 cites W1970599000 @default.
• W2045751930 cites W1970801073 @default.
• W2045751930 cites W1971361148 @default.
• W2045751930 cites W1971458488 @default.
• W2045751930 cites W1974010399 @default.
• W2045751930 cites W1976897618 @default.
• W2045751930 cites W1977145510 @default.
• W2045751930 cites W1977976903 @default.
• W2045751930 cites W1978688076 @default.
• W2045751930 cites W1979303367 @default.
• W2045751930 cites W1980725176 @default.
• W2045751930 cites W1981255217 @default.
• W2045751930 cites W1981906297 @default.
• W2045751930 cites W1983815491 @default.
• W2045751930 cites W1985544638 @default.
• W2045751930 cites W1985564615 @default.
• W2045751930 cites W1985679430 @default.
• W2045751930 cites W1987942256 @default.
• W2045751930 cites W1988845313 @default.
• W2045751930 cites W1989877475 @default.
• W2045751930 cites W1991450353 @default.
• W2045751930 cites W1992276686 @default.
• W2045751930 cites W1992350296 @default.
• W2045751930 cites W1992688638 @default.
• W2045751930 cites W1995796643 @default.
• W2045751930 cites W1998016799 @default.
• W2045751930 cites W1999206490 @default.
• W2045751930 cites W1999297429 @default.
• W2045751930 cites W1999930826 @default.
• W2045751930 cites W2000110243 @default.
• W2045751930 cites W2001828972 @default.
• W2045751930 cites W2002062291 @default.
• W2045751930 cites W2002466618 @default.
• W2045751930 cites W2002793136 @default.
• W2045751930 cites W2003196136 @default.
• W2045751930 cites W2003893279 @default.
• W2045751930 cites W2005393972 @default.
• W2045751930 cites W2005753349 @default.
• W2045751930 cites W2006976573 @default.
• W2045751930 cites W2007067931 @default.
• W2045751930 cites W2007635472 @default.
• W2045751930 cites W2008073080 @default.
• W2045751930 cites W2008226824 @default.
• W2045751930 cites W2008864694 @default.
• W2045751930 cites W2010901031 @default.
• W2045751930 cites W2011239067 @default.
• W2045751930 cites W2011320725 @default.
• W2045751930 cites W2015199349 @default.
• W2045751930 cites W2016115885 @default.
• W2045751930 cites W2016370817 @default.
• W2045751930 cites W2017065556 @default.
• W2045751930 cites W2018609920 @default.
• W2045751930 cites W2019779629 @default.
• W2045751930 cites W2021432006 @default.
• W2045751930 cites W2023324317 @default.
• W2045751930 cites W2024877615 @default.

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