FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045753014> ?p ?o ?g. }

• W2045753014 endingPage "77" @default.
• W2045753014 startingPage "67" @default.
• W2045753014 abstract "Insulin resistance is associated with diabetes. Hyperglycemia per se causes insulin resistance as well as increased flux of glucose through the hexosamine biosynthetic pathway. The rate-limiting enzyme for entry of glucose into this pathway is glutamine:fructose-6-phosphate amidotransferase (GFAT). To directly evaluate the role of GFAT in modulating insulin-stimulated glucose transport, we co-transfected primary cultures of rat adipose cells with expression vectors for human GFAT as well as an epitope-tagged GLUT4 and examined the effect of overexpressed GFAT on insulin-stimulated translocation of GLUT4. When we measured cell surface tagged GLUT4 in response to insulin, cells overexpressing GFAT and tagged GLUT4 had an insulin-dose response curve that was similar to that of control cells expressing only tagged GLUT4. As an alternative means of increasing flux through the hexosamine biosynthetic pathway, we incubated adipose cells with glucosamine (a substrate of the pathway downstream from GFAT) and insulin. Interestingly, for short incubation times (4 h) we observed a decrease in both basal and insulin-stimulated glucose transport without a detectable effect on insulin-stimulated translocation of GLUT4. However, for longer incubation times (16 h), we observed a significant decrease in the amount of GLUT4 in the plasma membrane. Our data suggest that products of the hexosamine biosynthetic pathway may cause insulin resistance, in part, by acutely decreasing intrinsic activity of GLUT4 as well as chronically altering the amount of GLUT4 at the cell surface." @default.
• W2045753014 created "2016-06-24" @default.
• W2045753014 creator A5011090841 @default.
• W2045753014 creator A5012901450 @default.
• W2045753014 creator A5035304169 @default.
• W2045753014 creator A5055615513 @default.
• W2045753014 creator A5059712516 @default.
• W2045753014 creator A5063213739 @default.
• W2045753014 date "1997-11-01" @default.
• W2045753014 modified "2023-10-03" @default.
• W2045753014 title "Effects of overexpression of glutamine:fructose-6-phosphate amidotransferase (GFAT) and glucosamine treatment on translocation of GLUT4 in rat adipose cells" @default.
• W2045753014 cites W1257903918 @default.
• W2045753014 cites W1500165569 @default.
• W2045753014 cites W1508811377 @default.
• W2045753014 cites W1513126834 @default.
• W2045753014 cites W1528896791 @default.
• W2045753014 cites W1563180403 @default.
• W2045753014 cites W1574665002 @default.
• W2045753014 cites W1586627930 @default.
• W2045753014 cites W1590732591 @default.
• W2045753014 cites W1605680188 @default.
• W2045753014 cites W1612870394 @default.
• W2045753014 cites W1620822945 @default.
• W2045753014 cites W1981590596 @default.
• W2045753014 cites W1984607512 @default.
• W2045753014 cites W1993842351 @default.
• W2045753014 cites W1994978663 @default.
• W2045753014 cites W2006312580 @default.
• W2045753014 cites W2037526260 @default.
• W2045753014 cites W2048670619 @default.
• W2045753014 cites W2051313176 @default.
• W2045753014 cites W2052308537 @default.
• W2045753014 cites W2056259190 @default.
• W2045753014 cites W2062292823 @default.
• W2045753014 cites W2072117280 @default.
• W2045753014 cites W2087910122 @default.
• W2045753014 cites W2095024386 @default.
• W2045753014 cites W2122000735 @default.
• W2045753014 cites W2126230664 @default.
• W2045753014 cites W2136433521 @default.
• W2045753014 cites W21490794 @default.
• W2045753014 cites W2334309509 @default.
• W2045753014 cites W4234129550 @default.
• W2045753014 cites W4239706493 @default.
• W2045753014 cites W4241727865 @default.
• W2045753014 cites W4247296847 @default.
• W2045753014 cites W4247342330 @default.
• W2045753014 doi "https://doi.org/10.1016/s0303-7207(97)00191-3" @default.
• W2045753014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9453242" @default.
• W2045753014 hasPublicationYear "1997" @default.
• W2045753014 type Work @default.
• W2045753014 sameAs 2045753014 @default.
• W2045753014 citedByCount "53" @default.
• W2045753014 countsByYear W20457530142012 @default.
• W2045753014 countsByYear W20457530142013 @default.
• W2045753014 countsByYear W20457530142014 @default.
• W2045753014 countsByYear W20457530142016 @default.
• W2045753014 countsByYear W20457530142021 @default.
• W2045753014 countsByYear W20457530142023 @default.
• W2045753014 crossrefType "journal-article" @default.
• W2045753014 hasAuthorship W2045753014A5011090841 @default.
• W2045753014 hasAuthorship W2045753014A5012901450 @default.
• W2045753014 hasAuthorship W2045753014A5035304169 @default.
• W2045753014 hasAuthorship W2045753014A5055615513 @default.
• W2045753014 hasAuthorship W2045753014A5059712516 @default.
• W2045753014 hasAuthorship W2045753014A5063213739 @default.
• W2045753014 hasConcept C126322002 @default.
• W2045753014 hasConcept C134018914 @default.
• W2045753014 hasConcept C161573976 @default.
• W2045753014 hasConcept C171089720 @default.
• W2045753014 hasConcept C185592680 @default.
• W2045753014 hasConcept C2776188179 @default.
• W2045753014 hasConcept C2777391703 @default.
• W2045753014 hasConcept C2777866211 @default.
• W2045753014 hasConcept C2779306644 @default.
• W2045753014 hasConcept C2779349466 @default.
• W2045753014 hasConcept C515207424 @default.
• W2045753014 hasConcept C55493867 @default.
• W2045753014 hasConcept C71924100 @default.
• W2045753014 hasConcept C86803240 @default.
• W2045753014 hasConceptScore W2045753014C126322002 @default.
• W2045753014 hasConceptScore W2045753014C134018914 @default.
• W2045753014 hasConceptScore W2045753014C161573976 @default.
• W2045753014 hasConceptScore W2045753014C171089720 @default.
• W2045753014 hasConceptScore W2045753014C185592680 @default.
• W2045753014 hasConceptScore W2045753014C2776188179 @default.
• W2045753014 hasConceptScore W2045753014C2777391703 @default.
• W2045753014 hasConceptScore W2045753014C2777866211 @default.
• W2045753014 hasConceptScore W2045753014C2779306644 @default.
• W2045753014 hasConceptScore W2045753014C2779349466 @default.
• W2045753014 hasConceptScore W2045753014C515207424 @default.
• W2045753014 hasConceptScore W2045753014C55493867 @default.
• W2045753014 hasConceptScore W2045753014C71924100 @default.
• W2045753014 hasConceptScore W2045753014C86803240 @default.
• W2045753014 hasIssue "1" @default.
• W2045753014 hasLocation W20457530141 @default.
• W2045753014 hasLocation W20457530142 @default.
• W2045753014 hasOpenAccess W2045753014 @default.

• next