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• W2045753826 abstract "A series of 3-aryl-1-(arylsulfonyl)-1,4,5,6-tetrahydropyridazine allosteric modulators of the GABAA receptor was synthesized, and biological activity was examined in vitro and in vivo. Beginning with 1a, stepwise modification of the substituents and conservation of the scaffold yielded a chemical series in which the modulatory activity was enhanced by the presence of GABA. The SAR suggests, but does not establish, that the compounds bind to the steroid binding site on the GABAA receptor. The GABA shift for each compound indicates that all compounds in this series are either agonists or partial agonists." @default.
• W2045753826 created "2016-06-24" @default.
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• W2045753826 date "1999-06-15" @default.
• W2045753826 modified "2023-09-26" @default.
• W2045753826 title "γ-Aminobutyrate-A Receptor Modulation by 3-Aryl-1-(arylsulfonyl)- 1,4,5,6-tetrahydropyridazines" @default.
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• W2045753826 doi "https://doi.org/10.1021/jm9805889" @default.
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