Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045755893> ?p ?o ?g. }
- W2045755893 endingPage "2225" @default.
- W2045755893 startingPage "2215" @default.
- W2045755893 abstract "Although the solute carrier 35B1 (SLC35B1) is evolutionarily conserved, its functions in metazoans remain unknown. To elucidate its function, we examined developmental roles of an SLC35B1 family gene (HUT-1: homolog of UDP-Gal transporter) in Caenorhabditis elegans. We isolated a deletion mutant of the gene and characterized phenotypes of the mutant and hut-1 RNAi-treated worms. GFP-HUT-1 reporter analysis was performed to examine gene expression patterns. We also tested whether several nucleotide sugar transporters can compensate for hut-1 deficiency. The hut-1 deletion mutant and RNAi worms showed larval growth defect and lethality with disrupted intestinal morphology. Inactivation of hut-1 induced chronic endoplasmic reticulum (ER) stress, and hut-1 showed genetic interactions with the atf-6, pek-1, and ire-1 genes involved in unfolded protein response signaling. ER ultrastructure and ER marker distribution in hut-1-deficient animals showed that HUT-1 is required for maintenance of ER structure. Reporter analysis revealed that HUT-1 is an ER protein ubiquitously expressed in tissues, including the intestine. Lethality and the ER stress phenotype of the mutant were rescued with the human hut-1 ortholog UGTrel1. These results indicate important roles for hut-1 in development and maintenance of ER homeostasis in C. elegans." @default.
- W2045755893 created "2016-06-24" @default.
- W2045755893 creator A5001822741 @default.
- W2045755893 creator A5008630128 @default.
- W2045755893 creator A5016807802 @default.
- W2045755893 creator A5017963517 @default.
- W2045755893 creator A5025429263 @default.
- W2045755893 creator A5068024974 @default.
- W2045755893 creator A5072772526 @default.
- W2045755893 creator A5074225425 @default.
- W2045755893 creator A5085568051 @default.
- W2045755893 date "2009-03-06" @default.
- W2045755893 modified "2023-10-17" @default.
- W2045755893 title "The ortholog of human solute carrier family 35 member B1 (UDP‐galactose transporter‐related protein 1) is involved in maintenance of ER homeostasis and essential for larval development in<i>Caenorhabditis elegans</i>" @default.
- W2045755893 cites W1536902696 @default.
- W2045755893 cites W1581412826 @default.
- W2045755893 cites W1839654349 @default.
- W2045755893 cites W1889455744 @default.
- W2045755893 cites W1944127002 @default.
- W2045755893 cites W1971258058 @default.
- W2045755893 cites W1976487490 @default.
- W2045755893 cites W1976730135 @default.
- W2045755893 cites W1976986966 @default.
- W2045755893 cites W1986737010 @default.
- W2045755893 cites W1993640232 @default.
- W2045755893 cites W2001593978 @default.
- W2045755893 cites W2001985026 @default.
- W2045755893 cites W2005299305 @default.
- W2045755893 cites W2005705236 @default.
- W2045755893 cites W2007078899 @default.
- W2045755893 cites W2010323829 @default.
- W2045755893 cites W2013743555 @default.
- W2045755893 cites W2020028608 @default.
- W2045755893 cites W2024274815 @default.
- W2045755893 cites W2029231885 @default.
- W2045755893 cites W2032239163 @default.
- W2045755893 cites W2039454906 @default.
- W2045755893 cites W2042954105 @default.
- W2045755893 cites W2051999277 @default.
- W2045755893 cites W2053470799 @default.
- W2045755893 cites W2054530726 @default.
- W2045755893 cites W2065803434 @default.
- W2045755893 cites W2077109576 @default.
- W2045755893 cites W2081331900 @default.
- W2045755893 cites W2085643898 @default.
- W2045755893 cites W2089198803 @default.
- W2045755893 cites W2100901456 @default.
- W2045755893 cites W2104315543 @default.
- W2045755893 cites W2105162027 @default.
- W2045755893 cites W2108126393 @default.
- W2045755893 cites W2112816530 @default.
- W2045755893 cites W2113785694 @default.
- W2045755893 cites W2114224169 @default.
- W2045755893 cites W2115734610 @default.
- W2045755893 cites W2124088653 @default.
- W2045755893 cites W2126610675 @default.
- W2045755893 cites W2128788229 @default.
- W2045755893 cites W2130567562 @default.
- W2045755893 cites W2131632095 @default.
- W2045755893 cites W2137662702 @default.
- W2045755893 cites W2139592877 @default.
- W2045755893 cites W2147873339 @default.
- W2045755893 cites W2150164025 @default.
- W2045755893 cites W2152268798 @default.
- W2045755893 cites W2153079301 @default.
- W2045755893 cites W2158173168 @default.
- W2045755893 cites W2158623906 @default.
- W2045755893 cites W2162679859 @default.
- W2045755893 cites W2166635722 @default.
- W2045755893 cites W2949524445 @default.
- W2045755893 cites W4237765655 @default.
- W2045755893 doi "https://doi.org/10.1096/fj.08-123737" @default.
- W2045755893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2704591" @default.
- W2045755893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19270184" @default.
- W2045755893 hasPublicationYear "2009" @default.
- W2045755893 type Work @default.
- W2045755893 sameAs 2045755893 @default.
- W2045755893 citedByCount "21" @default.
- W2045755893 countsByYear W20457558932013 @default.
- W2045755893 countsByYear W20457558932014 @default.
- W2045755893 countsByYear W20457558932016 @default.
- W2045755893 countsByYear W20457558932017 @default.
- W2045755893 countsByYear W20457558932018 @default.
- W2045755893 countsByYear W20457558932019 @default.
- W2045755893 countsByYear W20457558932020 @default.
- W2045755893 countsByYear W20457558932021 @default.
- W2045755893 countsByYear W20457558932022 @default.
- W2045755893 countsByYear W20457558932023 @default.
- W2045755893 crossrefType "journal-article" @default.
- W2045755893 hasAuthorship W2045755893A5001822741 @default.
- W2045755893 hasAuthorship W2045755893A5008630128 @default.
- W2045755893 hasAuthorship W2045755893A5016807802 @default.
- W2045755893 hasAuthorship W2045755893A5017963517 @default.
- W2045755893 hasAuthorship W2045755893A5025429263 @default.
- W2045755893 hasAuthorship W2045755893A5068024974 @default.
- W2045755893 hasAuthorship W2045755893A5072772526 @default.
- W2045755893 hasAuthorship W2045755893A5074225425 @default.
- W2045755893 hasAuthorship W2045755893A5085568051 @default.