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• W2045757903 abstract "Abstract Gsx class proteins are members of the ParaHox homeodomain transcription factor family with conserved roles in specification and patterning of the nervous system. We report the cloning of two Gsx genes, Gsh1 and Gsh2 , from the frog Xenopus tropicalis . We demonstrate the existence of a single, intact Xenopus ParaHox cluster, containing Gsh1, Pdx , and Cdx2 , plus three degenerate clusters containing Gsh2, Cdx1 , and Cdx4 . Anterior expression boundaries of genes from the intact ParaHox cluster are co‐linear with respect to their genomic organization. We show that Gsh1 and Gsh2 exhibit complex, overlapping patterns of expression within the anterior nervous system from open neural plate stages. We also find that expression of Gsh2, Nkx6 , and Msx1 across the medio‐lateral axis of the amphibian neural plate is strikingly similar to that of related genes in the Drosophila neuroectoderm. These findings provide further evidence for a conserved pathway regulating dorso‐ventral patterning in the Bilateria. Developmental Dynamics 238:194–203, 2009. © 2008 Wiley‐Liss, Inc." @default.
• W2045757903 created "2016-06-24" @default.
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• W2045757903 date "2008-12-18" @default.
• W2045757903 modified "2023-10-17" @default.
• W2045757903 title "Cloning and expression analysis of the anterior parahox genes, <i>Gsh1</i> and <i>Gsh2</i> from <i>Xenopus tropicalis</i>" @default.
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• W2045757903 doi "https://doi.org/10.1002/dvdy.21816" @default.
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