FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045763602> ?p ?o ?g. }

• W2045763602 endingPage "818" @default.
• W2045763602 startingPage "810" @default.
• W2045763602 abstract "Following our observation that erythrosine B (FD&C Red No. 3) is a relatively potent inhibitor of the TNF-R-TNFα and CD40-CD154 protein-protein interactions, we investigated whether this inhibitory activity extends to any other protein-protein interactions (PPI) as well as whether any other approved food colors possess such inhibitory activity. We found erythrosine, a poly-iodinated xanthene dye, to be a non-specific promiscuous inhibitor of a number of PPIs within the tumor necrosis factor superfamily (TNF-R-TNFα, CD40-CD154, BAFF-R-BAFF, RANK-RANKL, OX40-OX40L, 4-1BB-4-1BBL) as well as outside of it (EGF-R-EGF) with a remarkably consistent median inhibitory concentration (IC(50)) in the 2-20 μM (approximately 2-20mg/L) range. In agreement with this, erythrosine also showed cellular effects including clear cytotoxic effects around this concentration range (IC₅₀≈50 μM). Among the seven FDA-approved food colorants, only erythrosine showed consistent PPI inhibitory activity in the sub-100 μM range, which might also explain (at least partially) why it also has the lowest approved acceptable daily intake (ADI) (0.1 mg/kg body weight/day). Among a number of xanthene structural analogs of erythrosine tested for activity, rose Bengal, a food colorant approved in Japan, showed similar, maybe even more pronounced, promiscuous inhibitory activity, whereas fluorescein was inactive and gallein, phloxine, and eosin were somewhat active in some of the assays." @default.
• W2045763602 created "2016-06-24" @default.
• W2045763602 creator A5008179475 @default.
• W2045763602 creator A5045049371 @default.
• W2045763602 creator A5053964683 @default.
• W2045763602 creator A5054836047 @default.
• W2045763602 date "2011-03-01" @default.
• W2045763602 modified "2023-09-28" @default.
• W2045763602 title "The food colorant erythrosine is a promiscuous protein–protein interaction inhibitor" @default.
• W2045763602 cites W1542073216 @default.
• W2045763602 cites W188599489 @default.
• W2045763602 cites W1967805096 @default.
• W2045763602 cites W1971791991 @default.
• W2045763602 cites W1972863746 @default.
• W2045763602 cites W1982028243 @default.
• W2045763602 cites W1982333316 @default.
• W2045763602 cites W1990627326 @default.
• W2045763602 cites W2004427810 @default.
• W2045763602 cites W2008097040 @default.
• W2045763602 cites W2013146386 @default.
• W2045763602 cites W2014336773 @default.
• W2045763602 cites W2019173945 @default.
• W2045763602 cites W2021849042 @default.
• W2045763602 cites W2024868635 @default.
• W2045763602 cites W2026068701 @default.
• W2045763602 cites W2029640595 @default.
• W2045763602 cites W2032751799 @default.
• W2045763602 cites W2032884623 @default.
• W2045763602 cites W2041326043 @default.
• W2045763602 cites W2041767096 @default.
• W2045763602 cites W2047189301 @default.
• W2045763602 cites W2047612546 @default.
• W2045763602 cites W2058388959 @default.
• W2045763602 cites W2059388258 @default.
• W2045763602 cites W2060581674 @default.
• W2045763602 cites W2063379654 @default.
• W2045763602 cites W2066637531 @default.
• W2045763602 cites W2070849925 @default.
• W2045763602 cites W2072673869 @default.
• W2045763602 cites W2085070537 @default.
• W2045763602 cites W2088183908 @default.
• W2045763602 cites W2088846859 @default.
• W2045763602 cites W2093837089 @default.
• W2045763602 cites W2098933757 @default.
• W2045763602 cites W2099615371 @default.
• W2045763602 cites W2105287154 @default.
• W2045763602 cites W2106701169 @default.
• W2045763602 cites W2111186289 @default.
• W2045763602 cites W2121810998 @default.
• W2045763602 cites W2126107598 @default.
• W2045763602 cites W2127287358 @default.
• W2045763602 cites W2128581376 @default.
• W2045763602 cites W2142705057 @default.
• W2045763602 cites W2143183589 @default.
• W2045763602 cites W2154745487 @default.
• W2045763602 cites W2156643569 @default.
• W2045763602 cites W2161083455 @default.
• W2045763602 cites W264123879 @default.
• W2045763602 cites W4312600660 @default.
• W2045763602 cites W74887111 @default.
• W2045763602 doi "https://doi.org/10.1016/j.bcp.2010.12.020" @default.
• W2045763602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21219880" @default.
• W2045763602 hasPublicationYear "2011" @default.
• W2045763602 type Work @default.
• W2045763602 sameAs 2045763602 @default.
• W2045763602 citedByCount "57" @default.
• W2045763602 countsByYear W20457636022012 @default.
• W2045763602 countsByYear W20457636022013 @default.
• W2045763602 countsByYear W20457636022014 @default.
• W2045763602 countsByYear W20457636022015 @default.
• W2045763602 countsByYear W20457636022016 @default.
• W2045763602 countsByYear W20457636022017 @default.
• W2045763602 countsByYear W20457636022018 @default.
• W2045763602 countsByYear W20457636022019 @default.
• W2045763602 countsByYear W20457636022020 @default.
• W2045763602 countsByYear W20457636022021 @default.
• W2045763602 countsByYear W20457636022022 @default.
• W2045763602 countsByYear W20457636022023 @default.
• W2045763602 crossrefType "journal-article" @default.
• W2045763602 hasAuthorship W2045763602A5008179475 @default.
• W2045763602 hasAuthorship W2045763602A5045049371 @default.
• W2045763602 hasAuthorship W2045763602A5053964683 @default.
• W2045763602 hasAuthorship W2045763602A5054836047 @default.
• W2045763602 hasConcept C126322002 @default.
• W2045763602 hasConcept C17077164 @default.
• W2045763602 hasConcept C178790620 @default.
• W2045763602 hasConcept C185592680 @default.
• W2045763602 hasConcept C2776129442 @default.
• W2045763602 hasConcept C2777363021 @default.
• W2045763602 hasConcept C2780898351 @default.
• W2045763602 hasConcept C43617362 @default.
• W2045763602 hasConcept C71924100 @default.
• W2045763602 hasConcept C75473681 @default.
• W2045763602 hasConcept C98274493 @default.
• W2045763602 hasConceptScore W2045763602C126322002 @default.
• W2045763602 hasConceptScore W2045763602C17077164 @default.
• W2045763602 hasConceptScore W2045763602C178790620 @default.
• W2045763602 hasConceptScore W2045763602C185592680 @default.

• next