FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045768766> ?p ?o ?g. }

• W2045768766 endingPage "1868" @default.
• W2045768766 startingPage "1864" @default.
• W2045768766 abstract "Sarcolemmal Ca2+ movements in frog ventricular strips were measured by monitoring Ca2+ depletion from the extracellular space with an impermeant Ca indicator dye, antipyrylazo III. Ca2+ depletion was measured as a weighted average of light signals recorded simultaneously at three different wavelengths. This weighting procedure was designed to reduce the motion-induced light scattering and to enhance the Ca2+-related optical signals. Comparison of the time course of Ca2+ depletion signal with that of contraction showed that the rate of Ca2+ depletion was maximal immediately after the upstroke of the action potential but prior to the onset of tension. Peak Ca2+ depletion was reached toward the end of the action potential and amounted to a 10-50 microM decrease in the total extracellular Ca2+ concentration. The reaccumulation of extracellular Ca2+ seen after the action potential was 2-5 sec slower than the relaxation of tension. The rate of Ca2+ depletion had a bell-shaped voltage dependence and was enhanced by epinephrine, suggesting that Ca2+ influx occurred primarily through a slowly inactivating ionic channel. Ca2+ transport through the Na+-Ca2+ exchange system was not significantly altered in the presence of strophanthidin or with decrease of extracellular K+ concentration despite marked potentiation of tension by these agents. Ca2+ depletion measured at the end of a 1-sec clamp pulse had a voltage dependence noticeably different from that of the developed tension. This finding may suggest that a fraction of activator Ca2+ is released from membrane-bound Ca2+ pools in a voltage-dependent manner. Our results show that Ca2+ indicator dyes can be used not only to measure rapid changes in the extracellular Ca2+ concentration during contraction, but also to quantify the contribution of various sarcolemmal Ca2+ transport systems to the generation of tension in cardiac muscle." @default.
• W2045768766 created "2016-06-24" @default.
• W2045768766 creator A5021316321 @default.
• W2045768766 creator A5079194878 @default.
• W2045768766 creator A5087577548 @default.
• W2045768766 date "1985-03-01" @default.
• W2045768766 modified "2023-09-27" @default.
• W2045768766 title "Optical measurement of voltage-dependent Ca2+ influx in frog heart." @default.
• W2045768766 cites W1914136440 @default.
• W2045768766 cites W1967194868 @default.
• W2045768766 cites W1970206897 @default.
• W2045768766 cites W1980681406 @default.
• W2045768766 cites W1981272477 @default.
• W2045768766 cites W1999839533 @default.
• W2045768766 cites W2015816067 @default.
• W2045768766 cites W2016293198 @default.
• W2045768766 cites W2021386671 @default.
• W2045768766 cites W2027827595 @default.
• W2045768766 cites W2040647365 @default.
• W2045768766 cites W2040867636 @default.
• W2045768766 cites W2042598821 @default.
• W2045768766 cites W2048967165 @default.
• W2045768766 cites W2049624450 @default.
• W2045768766 cites W2052238098 @default.
• W2045768766 cites W2053682086 @default.
• W2045768766 cites W2068089024 @default.
• W2045768766 cites W2092513986 @default.
• W2045768766 cites W2120877263 @default.
• W2045768766 cites W2138151365 @default.
• W2045768766 cites W2138427708 @default.
• W2045768766 cites W2157766074 @default.
• W2045768766 cites W2315324589 @default.
• W2045768766 doi "https://doi.org/10.1073/pnas.82.6.1864" @default.
• W2045768766 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/397377" @default.
• W2045768766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2580301" @default.
• W2045768766 hasPublicationYear "1985" @default.
• W2045768766 type Work @default.
• W2045768766 sameAs 2045768766 @default.
• W2045768766 citedByCount "18" @default.
• W2045768766 crossrefType "journal-article" @default.
• W2045768766 hasAuthorship W2045768766A5021316321 @default.
• W2045768766 hasAuthorship W2045768766A5079194878 @default.
• W2045768766 hasAuthorship W2045768766A5087577548 @default.
• W2045768766 hasBestOaLocation W20457687662 @default.
• W2045768766 hasConcept C100837961 @default.
• W2045768766 hasConcept C104317684 @default.
• W2045768766 hasConcept C113196181 @default.
• W2045768766 hasConcept C12554922 @default.
• W2045768766 hasConcept C134018914 @default.
• W2045768766 hasConcept C163415756 @default.
• W2045768766 hasConcept C178790620 @default.
• W2045768766 hasConcept C181911157 @default.
• W2045768766 hasConcept C185592680 @default.
• W2045768766 hasConcept C28406088 @default.
• W2045768766 hasConcept C43617362 @default.
• W2045768766 hasConcept C517785266 @default.
• W2045768766 hasConcept C519063684 @default.
• W2045768766 hasConcept C537181965 @default.
• W2045768766 hasConcept C55493867 @default.
• W2045768766 hasConcept C86803240 @default.
• W2045768766 hasConcept C88045685 @default.
• W2045768766 hasConceptScore W2045768766C100837961 @default.
• W2045768766 hasConceptScore W2045768766C104317684 @default.
• W2045768766 hasConceptScore W2045768766C113196181 @default.
• W2045768766 hasConceptScore W2045768766C12554922 @default.
• W2045768766 hasConceptScore W2045768766C134018914 @default.
• W2045768766 hasConceptScore W2045768766C163415756 @default.
• W2045768766 hasConceptScore W2045768766C178790620 @default.
• W2045768766 hasConceptScore W2045768766C181911157 @default.
• W2045768766 hasConceptScore W2045768766C185592680 @default.
• W2045768766 hasConceptScore W2045768766C28406088 @default.
• W2045768766 hasConceptScore W2045768766C43617362 @default.
• W2045768766 hasConceptScore W2045768766C517785266 @default.
• W2045768766 hasConceptScore W2045768766C519063684 @default.
• W2045768766 hasConceptScore W2045768766C537181965 @default.
• W2045768766 hasConceptScore W2045768766C55493867 @default.
• W2045768766 hasConceptScore W2045768766C86803240 @default.
• W2045768766 hasConceptScore W2045768766C88045685 @default.
• W2045768766 hasIssue "6" @default.
• W2045768766 hasLocation W20457687661 @default.
• W2045768766 hasLocation W20457687662 @default.
• W2045768766 hasLocation W20457687663 @default.
• W2045768766 hasLocation W20457687664 @default.
• W2045768766 hasOpenAccess W2045768766 @default.
• W2045768766 hasPrimaryLocation W20457687661 @default.
• W2045768766 hasRelatedWork W1965391744 @default.
• W2045768766 hasRelatedWork W1986106260 @default.
• W2045768766 hasRelatedWork W1999185008 @default.
• W2045768766 hasRelatedWork W2005610124 @default.
• W2045768766 hasRelatedWork W2032484627 @default.
• W2045768766 hasRelatedWork W2050645918 @default.
• W2045768766 hasRelatedWork W2081943401 @default.
• W2045768766 hasRelatedWork W2102975580 @default.
• W2045768766 hasRelatedWork W2278763134 @default.
• W2045768766 hasRelatedWork W2410438787 @default.
• W2045768766 hasVolume "82" @default.
• W2045768766 isParatext "false" @default.
• W2045768766 isRetracted "false" @default.

• next