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• W2045773397 abstract "No AccessJournal of UrologyBasic Science1 Oct 2005IMMUNOLOCALIZATION OF ANDROGEN RECEPTOR AND ESTROGEN RECEPTORS α AND β IN HUMAN FETAL TESTIS AND EPIDIDYMISis corrected byERRATA ELLEN SHAPIRO, HONGYING HUANG, RACHEL J. MASCH, DEBORAH E. McFADDEN, XUE-RU WU, and HARRY OSTRER ELLEN SHAPIROELLEN SHAPIRO More articles by this author , HONGYING HUANGHONGYING HUANG More articles by this author , RACHEL J. MASCHRACHEL J. MASCH More articles by this author , DEBORAH E. McFADDENDEBORAH E. McFADDEN More articles by this author , XUE-RU WUXUE-RU WU More articles by this author , and HARRY OSTRERHARRY OSTRER More articles by this author View All Author Informationhttps://doi.org/10.1097/01.ju.0000179540.28209.deAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Expression and cellular localization of the androgen receptor (AR) and estrogen receptor (ER) isoforms were determined using antibodies specific to these receptors and to specific cell types. Materials and Methods: Gonads and genitourinary structures were removed from 5 human male fetuses 7 to 22 weeks of gestational age. Sections were stained with antibodies to AR, ERα and ERβ, P450 scc and smooth muscle actin. Results: AR was present in undifferentiated gonadal cells, peritubular myoid cells and in some Leydig and stromal cells at 7 weeks of gestation. The number of AR positive peritubular myoid cells remained constant through 22 weeks of gestation but the number of AR positive stromal cells continued to increase through 22 weeks. ERα was apparent by 12 weeks of gestation with perinuclear staining of Leydig cells, peaked at 16 weeks and then diminished. ERβ was first observed at 7 weeks in undifferentiated gonadal cells. By 12 weeks of gestation ERβ was apparent in germ cells, PTMC and Leydig cells. In the epididymis AR was expressed in the epithelium and stroma of the efferent ductules and the ductus epididymis by 7 weeks of gestation with increased expression by 12 weeks. A similar pattern of staining was observed for ERβ. By contrast, staining of ERα was observed only in the epithelium of the epididymis from 7 weeks of gestation onward with no apparent ERα staining in the tail of the epididymis. Conclusions: These findings are compatible with the well-known roles of androgen signaling in sexual differentiation and spermatogenesis in humans. The role of estrogens in the developing human testis and epididymis remains unknown. References 1 : Alterations of sex differentiation in males: from candidate genes to diagnosis and treatments. Curr Pharmaceut Design2004; 10: 501. Google Scholar 2 : Androgen insensitivity. Am J Med Genet1999; 89: 210. Google Scholar 3 : Involution of human fetal Leydig cells. An immunohistochemical, ultrastructural and quantitative study. J Anat1990; 172: 103. Google Scholar 4 : Cellular localization of rat testicular aromatase activity during development. Endocrinology1985; 116: 38. Google Scholar 5 : ER beta: identification and characterization of a novel human estrogen receptor. FEBS Lett1996; 392: 49. 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Google Scholar 18 : Estrogen action and male fertility: roles of the sodium/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function. Proc Natl Acad Sci USA2001; 98: 14132. Google Scholar 19 : Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc Natl Acad Sci USA1998; 95: 15677. Google Scholar 20 : Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med1994; 331: 1056. Google Scholar From the Departments of Urology (ES, HH, X-RW), Obstetrics and Gynecology (RJM), Pediatrics, Pathology and Medicine, and the Human Genetics Program (HO), New York University School of Medicine, New York, New York, and Department of Pathology, Children’s and Women’s Health Centre of British Columbia, Vancouver, British Columbia (DEM)© 2005 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byLiang J, Wang Z, Chiriboga L, Greco M, Shapiro E, Huang H, Yang X, Huang J, Peng Y, Melamed J, Garabedian M and Lee P (2018) The Expression and Function of Androgen Receptor Coactivator p44 and Protein Arginine Methyltransferase 5 in the Developing Testis and Testicular TumorsJournal of Urology, VOL. 177, NO. 5, (1918-1922), Online publication date: 1-May-2007.Related articlesJournal of Urology9 Nov 2018ERRATA Volume 174Issue 4 Part 2October 2005Page: 1695-1698 Advertisement Copyright & Permissions© 2005 by American Urological Association, Inc.Keywordsepididymisestrogenstestisreceptors, androgenMetricsAuthor Information ELLEN SHAPIRO More articles by this author HONGYING HUANG More articles by this author RACHEL J. MASCH More articles by this author DEBORAH E. McFADDEN More articles by this author XUE-RU WU More articles by this author HARRY OSTRER More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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