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- W2045774145 abstract "Therapy-related acute leukemia (t-AL) after exposure to DNA topoisomerase II inhibitors such as mitoxantrone (MTZ) is well known, with the vast majority of t-AL cases being reported in patients with a prior malignant disease.1,2 However, since the approval by the Food and Drug Administration and the European Agency for the Evaluation of Medicinal Products in 2000 of MTZ for treating aggressive forms of multiple sclerosis (MS), cases of t-AL have been increasingly reported.2–6 Nevertheless, the real incidence of t-AL in patients with MS treated with MTZ is not well established.### Case report.We report four cases of t-AL observed among the 142 patients with MS treated since 2001 with a common protocol of treatment with MTZ in the Valencian community, Spain (population 4,500,000 inhabitants, MS prevalence 55 per 100,000 inhabitants).7 Four different regimens of MTZ were administered (table), with a maximum dose of MTZ allowed of 120 mg/m2. Follow-up included clinical examination and serum biochemistry …" @default.
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- W2045774145 date "2008-08-04" @default.
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- W2045774145 title "FOUR NEW CASES OF THERAPY-RELATED ACUTE PROMYELOCYTIC LEUKEMIA AFTER MITOXANTRONE" @default.
- W2045774145 doi "https://doi.org/10.1212/01.wnl.0000324422.69067.e7" @default.
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