FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045777536> ?p ?o ?g. }

• W2045777536 endingPage "821" @default.
• W2045777536 startingPage "819" @default.
• W2045777536 abstract "Serotonin (5-hydroxytryptamine; 5-HT) is a bioamine neurotransmitter classically recognized for its importance in central nervous system (CNS) functions. Nevertheless, most of the body’s serotonin is peripherally located, with over 95 % of the body’s 5-HT produced in the intestine, where it modulates motility and secretion [1]. Intestinal 5-HT has also been demonstrated to play a major role in enteric nervous system development, intestinal epithelial homeostasis, and the modulation of intestinal inflammation [2–5]. Despite the recognition that intestinal inflammatory diseases such as ulcerative colitis (UC) can have strong genetic components [6], genetic polymorphisms linked with serotonin have not been associated with these disease states. In this issue of Digestive Diseases and Sciences, Sikander et al. [7] conducted the first prospective case– control study to demonstrate that there may be a potential association between polymorphisms in the 5-HT transporter (5-HTT) gene-linked polymorphic region (5HTTLPR) of the serotonin transporter (SERT) gene promoter and the intestinal inflammatory diseases UC and microscopic colitis (MC). In the intestine, 5-HT is produced by two different isoforms of the same biosynthetic enzyme, tryptophan hydroxylase (TPH). The vast majority (90 %) of 5-HT is produced by TPH1 in the enterochromaffin (EC) cells (and mast cells in rodents). The remainder is synthesized by TPH2 in enteric neurons [8]. TPH2 is also located in the neurons of the CNS. Under normal conditions, SERT terminates the action of released intestinal 5-HT via uptake into mucosal enterocytes and serotonergic neurons. The remaining 5-HT diffuses into the systemic circulation" @default.
• W2045777536 created "2016-06-24" @default.
• W2045777536 creator A5018989001 @default.
• W2045777536 creator A5040278204 @default.
• W2045777536 date "2015-03-03" @default.
• W2045777536 modified "2023-10-14" @default.
• W2045777536 title "Association of Serotonin Transporter Promoter Polymorphism (5HTTLPR) with Microscopic Colitis and Ulcerative Colitis: Time to Be AsSERTive?" @default.
• W2045777536 cites W1566638399 @default.
• W2045777536 cites W1969144895 @default.
• W2045777536 cites W1997066133 @default.
• W2045777536 cites W1999194156 @default.
• W2045777536 cites W2005534453 @default.
• W2045777536 cites W2014814979 @default.
• W2045777536 cites W2022461628 @default.
• W2045777536 cites W2022783819 @default.
• W2045777536 cites W2026987288 @default.
• W2045777536 cites W2041693050 @default.
• W2045777536 cites W2043598404 @default.
• W2045777536 cites W2049437507 @default.
• W2045777536 cites W2049871161 @default.
• W2045777536 cites W2051692635 @default.
• W2045777536 cites W2053908167 @default.
• W2045777536 cites W2055295898 @default.
• W2045777536 cites W2066285585 @default.
• W2045777536 cites W2067093184 @default.
• W2045777536 cites W2075583206 @default.
• W2045777536 cites W2080733464 @default.
• W2045777536 cites W2087048554 @default.
• W2045777536 cites W2088684629 @default.
• W2045777536 cites W2092534755 @default.
• W2045777536 cites W2097566770 @default.
• W2045777536 cites W2112881025 @default.
• W2045777536 cites W2125123579 @default.
• W2045777536 cites W2127242372 @default.
• W2045777536 cites W2133569423 @default.
• W2045777536 cites W2135444798 @default.
• W2045777536 cites W2141910384 @default.
• W2045777536 cites W2145135755 @default.
• W2045777536 cites W2155948158 @default.
• W2045777536 cites W2162610091 @default.
• W2045777536 cites W2168678503 @default.
• W2045777536 doi "https://doi.org/10.1007/s10620-015-3598-8" @default.
• W2045777536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4459509" @default.
• W2045777536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25732715" @default.
• W2045777536 hasPublicationYear "2015" @default.
• W2045777536 type Work @default.
• W2045777536 sameAs 2045777536 @default.
• W2045777536 citedByCount "12" @default.
• W2045777536 countsByYear W20457775362016 @default.
• W2045777536 countsByYear W20457775362017 @default.
• W2045777536 countsByYear W20457775362018 @default.
• W2045777536 countsByYear W20457775362019 @default.
• W2045777536 countsByYear W20457775362020 @default.
• W2045777536 countsByYear W20457775362022 @default.
• W2045777536 crossrefType "journal-article" @default.
• W2045777536 hasAuthorship W2045777536A5018989001 @default.
• W2045777536 hasAuthorship W2045777536A5040278204 @default.
• W2045777536 hasBestOaLocation W20457775361 @default.
• W2045777536 hasConcept C104317684 @default.
• W2045777536 hasConcept C126322002 @default.
• W2045777536 hasConcept C135763542 @default.
• W2045777536 hasConcept C149737253 @default.
• W2045777536 hasConcept C15744967 @default.
• W2045777536 hasConcept C170493617 @default.
• W2045777536 hasConcept C2775862500 @default.
• W2045777536 hasConcept C2775864247 @default.
• W2045777536 hasConcept C2778897192 @default.
• W2045777536 hasConcept C2779134260 @default.
• W2045777536 hasConcept C2780479503 @default.
• W2045777536 hasConcept C2909339193 @default.
• W2045777536 hasConcept C41260117 @default.
• W2045777536 hasConcept C54355233 @default.
• W2045777536 hasConcept C71924100 @default.
• W2045777536 hasConcept C86803240 @default.
• W2045777536 hasConcept C90924648 @default.
• W2045777536 hasConceptScore W2045777536C104317684 @default.
• W2045777536 hasConceptScore W2045777536C126322002 @default.
• W2045777536 hasConceptScore W2045777536C135763542 @default.
• W2045777536 hasConceptScore W2045777536C149737253 @default.
• W2045777536 hasConceptScore W2045777536C15744967 @default.
• W2045777536 hasConceptScore W2045777536C170493617 @default.
• W2045777536 hasConceptScore W2045777536C2775862500 @default.
• W2045777536 hasConceptScore W2045777536C2775864247 @default.
• W2045777536 hasConceptScore W2045777536C2778897192 @default.
• W2045777536 hasConceptScore W2045777536C2779134260 @default.
• W2045777536 hasConceptScore W2045777536C2780479503 @default.
• W2045777536 hasConceptScore W2045777536C2909339193 @default.
• W2045777536 hasConceptScore W2045777536C41260117 @default.
• W2045777536 hasConceptScore W2045777536C54355233 @default.
• W2045777536 hasConceptScore W2045777536C71924100 @default.
• W2045777536 hasConceptScore W2045777536C86803240 @default.
• W2045777536 hasConceptScore W2045777536C90924648 @default.
• W2045777536 hasIssue "4" @default.
• W2045777536 hasLocation W20457775361 @default.
• W2045777536 hasLocation W20457775362 @default.
• W2045777536 hasLocation W20457775363 @default.
• W2045777536 hasLocation W20457775364 @default.
• W2045777536 hasOpenAccess W2045777536 @default.

• next