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• W2045779801 startingPage "466" @default.
• W2045779801 abstract "Hematopoietic cell development in the liver of Rana pipiens throughout the larval period was examined. Differential counts of Wright/Giemsa-stained cell suspensions demonstrated that hepatic hematopoiesis includes lymphoid, myeloid, and erythroid cell lineages. Hematopoietic activity appeared to be initiated near the end of embryonic development (Shumway stages 24–25) and reached a substantial level by 30 days of development (Taylor and Kollros stage IV). Although lymphopoiesis became highly variable during later larval stages, granulopoiesis remained stable and erythropoiesis increased throughout the larval period. Erythropoiesis is the predominant hematopoietic activity in the larval liver. Histological examination of plastic embedded tissue demonstrated that hematopoietic activity is localized in discrete foci within the endothelial-lined sinusoids. These hematopoietic foci are found in both the subcapsular region and deeper portions of the organ. Microdensitometric analysis of experimental embryos which received chromosomally labeled presumptive ventral blood island transplants at Shumway stage 15 indicated that the derivatives of this embryonic region are limited to the circulating erythrocyte population of the early larvae. The hematopoietic cell populations of the liver appear to be derived from an extrinsic stem cell source which may be located in the dorsal region of the early embryo." @default.
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• W2045779801 date "1979-04-01" @default.
• W2045779801 modified "2023-09-26" @default.
• W2045779801 title "Experimental analysis of hematopoietic cell development in the liver of larval Rana pipiens" @default.
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• W2045779801 doi "https://doi.org/10.1016/0012-1606(79)90305-1" @default.
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