Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045783164> ?p ?o ?g. }
- W2045783164 endingPage "387" @default.
- W2045783164 startingPage "380" @default.
- W2045783164 abstract "The role of membrane transport in the cellular accumulation of 1-beta-D-arabinofuranosylcytosine (ara-C) was studied in freshly isolated human acute leukemia cells. Patient cells had low rates for ara-C transport as compared with human and murine experimental cells and correspondingly low binding capacities for the nucleoside transport inhibitor, nitrobenzylmercaptopurine riboside (NBMPR). At 1 microM ara-C, the rate of net cellular accumulation was close to the membrane transport rate, and NBMPR inhibited transport and accumulation to the same extent. The rate of ara-C accumulation was half maximal at only 3-5 microM, a level much lower than that required for murine cells (67-85 microM). At concentrations below 1 microM the rate of ara-C accumulation was determined primarily by the transport rate, but at higher concentrations above 10 microM, phosphorylation capacity was the principal determinant of the net uptake rate. This difference in the role of transport at high and low ara-C concentrations may explain, in part, the efficacy of high-dose ara-C in patients refractory to standard dose protocols." @default.
- W2045783164 created "2016-06-24" @default.
- W2045783164 creator A5016643170 @default.
- W2045783164 creator A5030842093 @default.
- W2045783164 creator A5060562909 @default.
- W2045783164 date "1987-02-01" @default.
- W2045783164 modified "2023-09-30" @default.
- W2045783164 title "Membrane transport influences the rate of accumulation of cytosine arabinoside in human leukemia cells." @default.
- W2045783164 cites W1500220303 @default.
- W2045783164 cites W1563779986 @default.
- W2045783164 cites W1593734262 @default.
- W2045783164 cites W1595276636 @default.
- W2045783164 cites W1609302917 @default.
- W2045783164 cites W1637765289 @default.
- W2045783164 cites W1767565691 @default.
- W2045783164 cites W1858613004 @default.
- W2045783164 cites W1963517397 @default.
- W2045783164 cites W1965783930 @default.
- W2045783164 cites W1980559044 @default.
- W2045783164 cites W2004135590 @default.
- W2045783164 cites W2009721237 @default.
- W2045783164 cites W2011865579 @default.
- W2045783164 cites W2012594892 @default.
- W2045783164 cites W2029938020 @default.
- W2045783164 cites W2042784970 @default.
- W2045783164 cites W2044837239 @default.
- W2045783164 cites W2050116858 @default.
- W2045783164 cites W2060876849 @default.
- W2045783164 cites W2074600677 @default.
- W2045783164 cites W2078230554 @default.
- W2045783164 cites W2096725836 @default.
- W2045783164 cites W2144901229 @default.
- W2045783164 cites W2146069035 @default.
- W2045783164 cites W2149582608 @default.
- W2045783164 cites W2164051062 @default.
- W2045783164 cites W2164249007 @default.
- W2045783164 cites W2169337684 @default.
- W2045783164 cites W2244390199 @default.
- W2045783164 cites W2397827554 @default.
- W2045783164 cites W2402641379 @default.
- W2045783164 cites W2403598312 @default.
- W2045783164 cites W2462779651 @default.
- W2045783164 cites W34803841 @default.
- W2045783164 cites W4022864 @default.
- W2045783164 cites W40973501 @default.
- W2045783164 cites W4301761088 @default.
- W2045783164 cites W203477811 @default.
- W2045783164 doi "https://doi.org/10.1172/jci112823" @default.
- W2045783164 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/424079" @default.
- W2045783164 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3805274" @default.
- W2045783164 hasPublicationYear "1987" @default.
- W2045783164 type Work @default.
- W2045783164 sameAs 2045783164 @default.
- W2045783164 citedByCount "107" @default.
- W2045783164 countsByYear W20457831642013 @default.
- W2045783164 countsByYear W20457831642014 @default.
- W2045783164 countsByYear W20457831642015 @default.
- W2045783164 countsByYear W20457831642016 @default.
- W2045783164 countsByYear W20457831642017 @default.
- W2045783164 countsByYear W20457831642018 @default.
- W2045783164 countsByYear W20457831642019 @default.
- W2045783164 countsByYear W20457831642020 @default.
- W2045783164 countsByYear W20457831642021 @default.
- W2045783164 countsByYear W20457831642022 @default.
- W2045783164 countsByYear W20457831642023 @default.
- W2045783164 crossrefType "journal-article" @default.
- W2045783164 hasAuthorship W2045783164A5016643170 @default.
- W2045783164 hasAuthorship W2045783164A5030842093 @default.
- W2045783164 hasAuthorship W2045783164A5060562909 @default.
- W2045783164 hasBestOaLocation W20457831641 @default.
- W2045783164 hasConcept C153911025 @default.
- W2045783164 hasConcept C185592680 @default.
- W2045783164 hasConcept C203014093 @default.
- W2045783164 hasConcept C2776023528 @default.
- W2045783164 hasConcept C2776543447 @default.
- W2045783164 hasConcept C2778041864 @default.
- W2045783164 hasConcept C2778461978 @default.
- W2045783164 hasConcept C41625074 @default.
- W2045783164 hasConcept C552990157 @default.
- W2045783164 hasConcept C55493867 @default.
- W2045783164 hasConcept C57947595 @default.
- W2045783164 hasConcept C86803240 @default.
- W2045783164 hasConceptScore W2045783164C153911025 @default.
- W2045783164 hasConceptScore W2045783164C185592680 @default.
- W2045783164 hasConceptScore W2045783164C203014093 @default.
- W2045783164 hasConceptScore W2045783164C2776023528 @default.
- W2045783164 hasConceptScore W2045783164C2776543447 @default.
- W2045783164 hasConceptScore W2045783164C2778041864 @default.
- W2045783164 hasConceptScore W2045783164C2778461978 @default.
- W2045783164 hasConceptScore W2045783164C41625074 @default.
- W2045783164 hasConceptScore W2045783164C552990157 @default.
- W2045783164 hasConceptScore W2045783164C55493867 @default.
- W2045783164 hasConceptScore W2045783164C57947595 @default.
- W2045783164 hasConceptScore W2045783164C86803240 @default.
- W2045783164 hasIssue "2" @default.
- W2045783164 hasLocation W20457831641 @default.
- W2045783164 hasLocation W20457831642 @default.
- W2045783164 hasLocation W20457831643 @default.