FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045784210> ?p ?o ?g. }

• W2045784210 endingPage "148" @default.
• W2045784210 startingPage "138" @default.
• W2045784210 abstract "Clotrimazole was formulated in nanoemulsion based system with the aim of improving its solubility and dissolution, which can further used for its preclinical evaluation. Clotrimazole nanoemulsion was prepared using spontaneous nanoemulsification method. Preformulation studies were preformed to evaluate drug-excipient compatibility, solution state pH stability and pH solubility profile. Solubility of clotrimazole in oils, surfactants and cosurfactants was determined to identify nanoemulsion components. Surfactants and cosurfactants were screened for their ability to emulsify selected oily phases. Phase diagrams were constructed to identify area of nanoemulsification. Influence of clotrimazole and pH of dilution medium on phase behavior were assessed. Drug-excipient chemical compatibility study facilitated to anticipate acid catalyzed degradation of clotrimazole. The pH of nanoemulsion was adjusted to 7.5, which could stabilize clotrimazole. Nanoemulsion composed of Capryol 90, Solutol HS 15 and Gelucire 44/14 enhanced solubility of clotrimazole up to 25mg/ml. The optimized clotrimazole nanoemulsion could withstand the extensive dilution and did not show any phase separation or drug precipitation. The nanoemulsion exhibited mean globule size <25 nm, which was not affected by pH of dilution medium. Dissolution profile of clotrimazole nanoemulsion in various media showed 100% drug release within 15 min irrespective of pH of medium." @default.
• W2045784210 created "2016-06-24" @default.
• W2045784210 creator A5007769890 @default.
• W2045784210 creator A5026177562 @default.
• W2045784210 creator A5068323156 @default.
• W2045784210 creator A5075868662 @default.
• W2045784210 date "2012-07-01" @default.
• W2045784210 modified "2023-09-27" @default.
• W2045784210 title "Clotrimazole nanoemulsion for malaria chemotherapy. Part I: Preformulation studies, formulation design and physicochemical evaluation" @default.
• W2045784210 cites W1964575627 @default.
• W2045784210 cites W1966104273 @default.
• W2045784210 cites W1972189607 @default.
• W2045784210 cites W1974008347 @default.
• W2045784210 cites W1979063088 @default.
• W2045784210 cites W1981405716 @default.
• W2045784210 cites W1981493239 @default.
• W2045784210 cites W2006737992 @default.
• W2045784210 cites W2010357659 @default.
• W2045784210 cites W2011068615 @default.
• W2045784210 cites W2031177552 @default.
• W2045784210 cites W2037971636 @default.
• W2045784210 cites W2042237497 @default.
• W2045784210 cites W2046575180 @default.
• W2045784210 cites W2048080607 @default.
• W2045784210 cites W2052448424 @default.
• W2045784210 cites W2056995570 @default.
• W2045784210 cites W2057096079 @default.
• W2045784210 cites W2065940471 @default.
• W2045784210 cites W2075655654 @default.
• W2045784210 cites W2076448476 @default.
• W2045784210 cites W2083801949 @default.
• W2045784210 cites W2090739444 @default.
• W2045784210 cites W2118697938 @default.
• W2045784210 cites W2133048957 @default.
• W2045784210 cites W2147834398 @default.
• W2045784210 cites W2156465764 @default.
• W2045784210 cites W2164862526 @default.
• W2045784210 cites W2166547808 @default.
• W2045784210 cites W2170431704 @default.
• W2045784210 doi "https://doi.org/10.1016/j.ijpharm.2011.12.040" @default.
• W2045784210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22227344" @default.
• W2045784210 hasPublicationYear "2012" @default.
• W2045784210 type Work @default.
• W2045784210 sameAs 2045784210 @default.
• W2045784210 citedByCount "104" @default.
• W2045784210 countsByYear W20457842102012 @default.
• W2045784210 countsByYear W20457842102013 @default.
• W2045784210 countsByYear W20457842102014 @default.
• W2045784210 countsByYear W20457842102015 @default.
• W2045784210 countsByYear W20457842102016 @default.
• W2045784210 countsByYear W20457842102017 @default.
• W2045784210 countsByYear W20457842102018 @default.
• W2045784210 countsByYear W20457842102019 @default.
• W2045784210 countsByYear W20457842102020 @default.
• W2045784210 countsByYear W20457842102021 @default.
• W2045784210 countsByYear W20457842102022 @default.
• W2045784210 countsByYear W20457842102023 @default.
• W2045784210 crossrefType "journal-article" @default.
• W2045784210 hasAuthorship W2045784210A5007769890 @default.
• W2045784210 hasAuthorship W2045784210A5026177562 @default.
• W2045784210 hasAuthorship W2045784210A5068323156 @default.
• W2045784210 hasAuthorship W2045784210A5075868662 @default.
• W2045784210 hasConcept C121332964 @default.
• W2045784210 hasConcept C155574463 @default.
• W2045784210 hasConcept C16005928 @default.
• W2045784210 hasConcept C178790620 @default.
• W2045784210 hasConcept C185592680 @default.
• W2045784210 hasConcept C2777239854 @default.
• W2045784210 hasConcept C2779548794 @default.
• W2045784210 hasConcept C2780628323 @default.
• W2045784210 hasConcept C43617362 @default.
• W2045784210 hasConcept C71924100 @default.
• W2045784210 hasConcept C77281830 @default.
• W2045784210 hasConcept C88380143 @default.
• W2045784210 hasConcept C96618451 @default.
• W2045784210 hasConcept C97355855 @default.
• W2045784210 hasConceptScore W2045784210C121332964 @default.
• W2045784210 hasConceptScore W2045784210C155574463 @default.
• W2045784210 hasConceptScore W2045784210C16005928 @default.
• W2045784210 hasConceptScore W2045784210C178790620 @default.
• W2045784210 hasConceptScore W2045784210C185592680 @default.
• W2045784210 hasConceptScore W2045784210C2777239854 @default.
• W2045784210 hasConceptScore W2045784210C2779548794 @default.
• W2045784210 hasConceptScore W2045784210C2780628323 @default.
• W2045784210 hasConceptScore W2045784210C43617362 @default.
• W2045784210 hasConceptScore W2045784210C71924100 @default.
• W2045784210 hasConceptScore W2045784210C77281830 @default.
• W2045784210 hasConceptScore W2045784210C88380143 @default.
• W2045784210 hasConceptScore W2045784210C96618451 @default.
• W2045784210 hasConceptScore W2045784210C97355855 @default.
• W2045784210 hasIssue "1-2" @default.
• W2045784210 hasLocation W20457842101 @default.
• W2045784210 hasLocation W20457842102 @default.
• W2045784210 hasOpenAccess W2045784210 @default.
• W2045784210 hasPrimaryLocation W20457842101 @default.
• W2045784210 hasRelatedWork W1967000099 @default.
• W2045784210 hasRelatedWork W1972121686 @default.
• W2045784210 hasRelatedWork W1973983924 @default.

• next