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- W2045784517 abstract "Myasthenia gravis (MG) primarily affects skeletal muscle through the production of autoantibodies against the nicotinic acetylcholine receptor in the motor endplates; in addition, heart muscle is an autoimmune target. We describe 2 illustrative cases of myasthenia gravis (MG)-related cardiomyopathy. The first case is a 63-year-old man treated for the decreased left ventricular systolic function and the positive results of autoantibody against striational proteins. The self-discontinuation of immunosuppressive agents was suggested to result in acute decompensated heart failure with serum levels of cardiac troponin I of 0.461 ng/mL and death. The second case is a 70-year-old man who was admitted due to the worsening of heart failure. Intensive immunosuppressive treatment successfully prevented the exacerbation of heart failure and decreased elevated troponin levels. Although a cohort study regarding cardiac troponins in patients with MG has not been reported, serial measurements may be useful in monitoring for cardiac damage of MG-related cardiomyopathy. An early detection and timely treatment is important in MG-related cardiomyopathy. In addition, a clear definition for the diagnosis is warranted." @default.
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- W2045784517 date "2013-10-01" @default.
- W2045784517 modified "2023-09-27" @default.
- W2045784517 title "Two Cases of Myasthenia Gravis-related Cardiomyopathy: A Rare, Life-threatening, but Treatable Cardiomyopathy" @default.
- W2045784517 doi "https://doi.org/10.1016/j.cardfail.2013.08.480" @default.
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