FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045785089> ?p ?o ?g. }

• W2045785089 endingPage "e94331" @default.
• W2045785089 startingPage "e94331" @default.
• W2045785089 abstract "The large-conductance Ca2+-activated K+ (BK) channel is broadly expressed in various mammalian cells and tissues such as neurons, skeletal and smooth muscles, exocrine cells, and sensory cells of the inner ear. Previous studies suggest that BK channels are promiscuous binders involved in a multitude of protein-protein interactions. To gain a better understanding of the potential mechanisms underlying BK interactions, we analyzed the abundance, distribution, and potential mechanisms of intrinsic disorder in 27 BK channel variants from mouse cochlea, 104 previously reported BK-associated proteins (BKAPS) from cytoplasmic and membrane/cytoskeletal regions, plus BK β- and γ-subunits. Disorder was evaluated using the MFDp algorithm, which is a consensus-based predictor that provides a strong and competitive predictive quality and PONDR, which can determine long intrinsically disordered regions (IDRs). Disorder-based binding sites or molecular recognition features (MoRFs) were found using MoRFpred and ANCHOR. BKAP functions were categorized based on Gene Ontology (GO) terms. The analyses revealed that the BK variants contain a number of IDRs. Intrinsic disorder is also common in BKAPs, of which ∼5% are completely disordered. However, intrinsic disorder is very differently distributed within BK and its partners. Approximately 65% of the disordered segments in BK channels are long (IDRs) (>50 residues), whereas >60% of the disordered segments in BKAPs are short IDRs that range in length from 4 to 30 residues. Both α and γ subunits showed various amounts of disorder as did hub proteins of the BK interactome. Our analyses suggest that intrinsic disorder is important for the function of BK and its BKAPs. Long IDRs in BK are engaged in protein-protein and protein-ligand interactions, contain multiple post-translational modification sites, and are subjected to alternative splicing. The disordered structure of BK and its BKAPs suggests one of the underlying mechanisms of their interaction." @default.
• W2045785089 created "2016-06-24" @default.
• W2045785089 creator A5020435329 @default.
• W2045785089 creator A5027921186 @default.
• W2045785089 creator A5083199032 @default.
• W2045785089 creator A5084253357 @default.
• W2045785089 creator A5088423732 @default.
• W2045785089 date "2014-04-11" @default.
• W2045785089 modified "2023-10-17" @default.
• W2045785089 title "Intrinsic Disorder in the BK Channel and Its Interactome" @default.
• W2045785089 cites W1554017431 @default.
• W2045785089 cites W1575457444 @default.
• W2045785089 cites W1964512347 @default.
• W2045785089 cites W1964555160 @default.
• W2045785089 cites W1975121208 @default.
• W2045785089 cites W1975622992 @default.
• W2045785089 cites W1982250822 @default.
• W2045785089 cites W1987407788 @default.
• W2045785089 cites W1990262394 @default.
• W2045785089 cites W1990426574 @default.
• W2045785089 cites W1990705961 @default.
• W2045785089 cites W1994471332 @default.
• W2045785089 cites W1996572869 @default.
• W2045785089 cites W1997556750 @default.
• W2045785089 cites W1998675589 @default.
• W2045785089 cites W1998719957 @default.
• W2045785089 cites W1998921314 @default.
• W2045785089 cites W2005572147 @default.
• W2045785089 cites W2008116827 @default.
• W2045785089 cites W2019051015 @default.
• W2045785089 cites W2021797996 @default.
• W2045785089 cites W2023333666 @default.
• W2045785089 cites W2024120282 @default.
• W2045785089 cites W2027035874 @default.
• W2045785089 cites W2028275047 @default.
• W2045785089 cites W2030776726 @default.
• W2045785089 cites W2034299708 @default.
• W2045785089 cites W2036114259 @default.
• W2045785089 cites W2038292812 @default.
• W2045785089 cites W2049476357 @default.
• W2045785089 cites W2050256938 @default.
• W2045785089 cites W2052366943 @default.
• W2045785089 cites W2052894646 @default.
• W2045785089 cites W2053820259 @default.
• W2045785089 cites W2055226297 @default.
• W2045785089 cites W2055410342 @default.
• W2045785089 cites W2063845237 @default.
• W2045785089 cites W2065692451 @default.
• W2045785089 cites W2066278869 @default.
• W2045785089 cites W2070496155 @default.
• W2045785089 cites W2074512046 @default.
• W2045785089 cites W2077588132 @default.
• W2045785089 cites W2079933098 @default.
• W2045785089 cites W2080666574 @default.
• W2045785089 cites W2085701920 @default.
• W2045785089 cites W2087064593 @default.
• W2045785089 cites W2101953406 @default.
• W2045785089 cites W2103743266 @default.
• W2045785089 cites W2113985551 @default.
• W2045785089 cites W2114823344 @default.
• W2045785089 cites W2115190629 @default.
• W2045785089 cites W2115676911 @default.
• W2045785089 cites W2118608964 @default.
• W2045785089 cites W2119986079 @default.
• W2045785089 cites W2120744225 @default.
• W2045785089 cites W2122563317 @default.
• W2045785089 cites W2125162914 @default.
• W2045785089 cites W2128413613 @default.
• W2045785089 cites W2129261098 @default.
• W2045785089 cites W2132720084 @default.
• W2045785089 cites W2137015675 @default.
• W2045785089 cites W2138289501 @default.
• W2045785089 cites W2141378441 @default.
• W2045785089 cites W2143593035 @default.
• W2045785089 cites W2144252381 @default.
• W2045785089 cites W2145023212 @default.
• W2045785089 cites W2147387679 @default.
• W2045785089 cites W2149472608 @default.
• W2045785089 cites W2150686509 @default.
• W2045785089 cites W2152265734 @default.
• W2045785089 cites W2153187042 @default.
• W2045785089 cites W2153591439 @default.
• W2045785089 cites W2153971450 @default.
• W2045785089 cites W2156407548 @default.
• W2045785089 cites W2156606811 @default.
• W2045785089 cites W2158714788 @default.
• W2045785089 cites W2159938554 @default.
• W2045785089 cites W2161199282 @default.
• W2045785089 cites W2162720882 @default.
• W2045785089 cites W2168220711 @default.
• W2045785089 cites W2169802764 @default.
• W2045785089 cites W2170380046 @default.
• W2045785089 cites W2170623915 @default.
• W2045785089 cites W2171092071 @default.
• W2045785089 cites W2322304557 @default.
• W2045785089 cites W4210968583 @default.
• W2045785089 cites W4233334497 @default.
• W2045785089 cites W4320301318 @default.

• next