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- W2045792217 abstract "The effects of exogenous short-chain ceramide (1) on the arrest of growth of cancer cells in vitro and induction of apoptosis have been well documented. In the present study, an analog of 1 with a disulfide linkage, N-(4',5'-dithiaheptanoyl)-D-erythro-ceramide (2), was synthesized and found to be significantly more antiproliferative and cytotoxic than 1 in BT549, A549, and DU145 cancer cells. The activity was correlated with a reduction in cellular glutathione (GSH) level. Ceramide analogs with a tri- and tetra-sulfide moiety were also prepared, but they did not deplete cellular GSH levels and did not possess antiproliferative or cytotoxic properties." @default.
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- W2045792217 date "2007-06-01" @default.
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- W2045792217 title "Anticancer activity of a ceramide analog containing a disulfide linkage" @default.
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- W2045792217 doi "https://doi.org/10.1016/j.canlet.2006.10.026" @default.
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