Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045792350> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2045792350 abstract "The ATP synthase is known to play important roles in ATP generation and proton translocation within mitochondria. Here, we now provide evidence showing the presence of functional ecto-ATP synthase on the neuronal surface. Immunoblotting revealed that the α, β subunits of ATP synthase F1 portion are present in isolated fractions of plasma membrane and biotin-labelled surface protein from primary cultured neurons; the surface distribution of α, β subunits was also confirmed by immunofluorescence staining. Moreover, α and β subunits were also found in fractions of plasma membrane and lipid rafts isolated from rat brain, and flow cytometry analysis showed α subunits on the surface of acutely isolated brain cells. Activity assays showed that the extracellular ATP generation of cultured neurons could be compromised by α, β subunit antibodies and ATP synthase inhibitors. pH(i) (intracellular pH) analysis demonstrated that at low extracellular pH, α or β subunit antibodies decreased pHi of primary cultured neurons. Therefore, ATP synthase on the surface of neurons may be involved in the machineries of extracellular ATP generation and pH(i) homoeostasis." @default.
- W2045792350 created "2016-06-24" @default.
- W2045792350 creator A5016337270 @default.
- W2045792350 creator A5053149172 @default.
- W2045792350 creator A5065372602 @default.
- W2045792350 creator A5069298555 @default.
- W2045792350 date "2010-07-14" @default.
- W2045792350 modified "2023-10-16" @default.
- W2045792350 title "Neuronal cell surface ATP synthase mediates synthesis of extracellular ATP and regulation of intracellular pH" @default.
- W2045792350 doi "https://doi.org/10.1042/cbi20090441" @default.
- W2045792350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20626349" @default.
- W2045792350 hasPublicationYear "2010" @default.
- W2045792350 type Work @default.
- W2045792350 sameAs 2045792350 @default.
- W2045792350 citedByCount "12" @default.
- W2045792350 countsByYear W20457923502012 @default.
- W2045792350 countsByYear W20457923502015 @default.
- W2045792350 countsByYear W20457923502021 @default.
- W2045792350 countsByYear W20457923502022 @default.
- W2045792350 countsByYear W20457923502023 @default.
- W2045792350 crossrefType "journal-article" @default.
- W2045792350 hasAuthorship W2045792350A5016337270 @default.
- W2045792350 hasAuthorship W2045792350A5053149172 @default.
- W2045792350 hasAuthorship W2045792350A5065372602 @default.
- W2045792350 hasAuthorship W2045792350A5069298555 @default.
- W2045792350 hasConcept C104292427 @default.
- W2045792350 hasConcept C104317684 @default.
- W2045792350 hasConcept C112243037 @default.
- W2045792350 hasConcept C119120687 @default.
- W2045792350 hasConcept C141315368 @default.
- W2045792350 hasConcept C153911025 @default.
- W2045792350 hasConcept C181199279 @default.
- W2045792350 hasConcept C185592680 @default.
- W2045792350 hasConcept C191678065 @default.
- W2045792350 hasConcept C23265538 @default.
- W2045792350 hasConcept C28406088 @default.
- W2045792350 hasConcept C28859421 @default.
- W2045792350 hasConcept C55493867 @default.
- W2045792350 hasConcept C79879829 @default.
- W2045792350 hasConcept C86803240 @default.
- W2045792350 hasConcept C95444343 @default.
- W2045792350 hasConceptScore W2045792350C104292427 @default.
- W2045792350 hasConceptScore W2045792350C104317684 @default.
- W2045792350 hasConceptScore W2045792350C112243037 @default.
- W2045792350 hasConceptScore W2045792350C119120687 @default.
- W2045792350 hasConceptScore W2045792350C141315368 @default.
- W2045792350 hasConceptScore W2045792350C153911025 @default.
- W2045792350 hasConceptScore W2045792350C181199279 @default.
- W2045792350 hasConceptScore W2045792350C185592680 @default.
- W2045792350 hasConceptScore W2045792350C191678065 @default.
- W2045792350 hasConceptScore W2045792350C23265538 @default.
- W2045792350 hasConceptScore W2045792350C28406088 @default.
- W2045792350 hasConceptScore W2045792350C28859421 @default.
- W2045792350 hasConceptScore W2045792350C55493867 @default.
- W2045792350 hasConceptScore W2045792350C79879829 @default.
- W2045792350 hasConceptScore W2045792350C86803240 @default.
- W2045792350 hasConceptScore W2045792350C95444343 @default.
- W2045792350 hasLocation W20457923501 @default.
- W2045792350 hasLocation W20457923502 @default.
- W2045792350 hasOpenAccess W2045792350 @default.
- W2045792350 hasPrimaryLocation W20457923501 @default.
- W2045792350 hasRelatedWork W1521333523 @default.
- W2045792350 hasRelatedWork W1538215898 @default.
- W2045792350 hasRelatedWork W1988039131 @default.
- W2045792350 hasRelatedWork W2044417247 @default.
- W2045792350 hasRelatedWork W2075329192 @default.
- W2045792350 hasRelatedWork W2195476643 @default.
- W2045792350 hasRelatedWork W2284622490 @default.
- W2045792350 hasRelatedWork W2375649700 @default.
- W2045792350 hasRelatedWork W2588900732 @default.
- W2045792350 hasRelatedWork W3205712246 @default.
- W2045792350 isParatext "false" @default.
- W2045792350 isRetracted "false" @default.
- W2045792350 magId "2045792350" @default.
- W2045792350 workType "article" @default.