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- W2045792492 abstract "Immunization of pigs with a modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine initially elicits a weak interferon (IFN)-γ response. To improve the immune response, an adjuvant consisting of plasmid encoding either porcine interleukin (IL)-12 or IFN-α was co-administered during vaccination. In the presence of either adjuvant, at least a three-fold increase in the primary virus-specific IFN-γ response was observed. While this enhancement was only transient (1 week) when the IL-12 expressing plasmid was used, the effect was not only still apparent at 6 weeks after vaccination in the presence of the IFN-α expressing plasmid but even after challenge with a virulent genetically divergent PRRSV. In contrast, no effect of either adjuvant on the production of anti-virus antibodies was noticed throughout the study. Despite the apparent augmentation of a T helper (Th) 1 type response by the inclusion of IFN-α or IL-12 during vaccination, this modulation did not necessarily correlate with a reduction in viremia. Since a similar increase in the degree of the IFN-γ response to the PRRSV vaccine could be achieved by substituting polyinosinic–polycytidylic acid in lieu of either cytokine, exposure to PRRSV in the presence of a variety of Th 1 polarizing molecules can positively influence the development of the cell-mediated immune response of swine to this pathogen. Conceivably, such intervention could be applied to improve the formulation of anti-PRRSV vaccines." @default.
- W2045792492 created "2016-06-24" @default.
- W2045792492 creator A5009191247 @default.
- W2045792492 creator A5013943720 @default.
- W2045792492 creator A5016608854 @default.
- W2045792492 creator A5018248999 @default.
- W2045792492 creator A5051080238 @default.
- W2045792492 creator A5083684557 @default.
- W2045792492 date "2004-12-01" @default.
- W2045792492 modified "2023-09-28" @default.
- W2045792492 title "Cytokines and synthetic double-stranded RNA augment the T helper 1 immune response of swine to porcine reproductive and respiratory syndrome virus" @default.
- W2045792492 cites W137726580 @default.
- W2045792492 cites W1502386716 @default.
- W2045792492 cites W1511825494 @default.
- W2045792492 cites W1526789785 @default.
- W2045792492 cites W1550814250 @default.
- W2045792492 cites W1602676845 @default.
- W2045792492 cites W1642318346 @default.
- W2045792492 cites W1967679039 @default.
- W2045792492 cites W1973533638 @default.
- W2045792492 cites W1977085700 @default.
- W2045792492 cites W1980021485 @default.
- W2045792492 cites W1981746803 @default.
- W2045792492 cites W1981969796 @default.
- W2045792492 cites W1985569415 @default.
- W2045792492 cites W1986497228 @default.
- W2045792492 cites W1987429299 @default.
- W2045792492 cites W1987786107 @default.
- W2045792492 cites W1988560142 @default.
- W2045792492 cites W1990350083 @default.
- W2045792492 cites W1990890248 @default.
- W2045792492 cites W1994310347 @default.
- W2045792492 cites W1997384271 @default.
- W2045792492 cites W1999070120 @default.
- W2045792492 cites W1999587028 @default.
- W2045792492 cites W2000710670 @default.
- W2045792492 cites W2002022916 @default.
- W2045792492 cites W2002180372 @default.
- W2045792492 cites W2007766444 @default.
- W2045792492 cites W2007802775 @default.
- W2045792492 cites W2009313996 @default.
- W2045792492 cites W2012121871 @default.
- W2045792492 cites W2013435693 @default.
- W2045792492 cites W2013840551 @default.
- W2045792492 cites W2014212115 @default.
- W2045792492 cites W2015721404 @default.
- W2045792492 cites W2019099694 @default.
- W2045792492 cites W2021751941 @default.
- W2045792492 cites W2025843699 @default.
- W2045792492 cites W2027005967 @default.
- W2045792492 cites W2029571878 @default.
- W2045792492 cites W2030190658 @default.
- W2045792492 cites W2030912283 @default.
- W2045792492 cites W2032913157 @default.
- W2045792492 cites W2037260140 @default.
- W2045792492 cites W2040024010 @default.
- W2045792492 cites W2040430948 @default.
- W2045792492 cites W2045509929 @default.
- W2045792492 cites W2046829837 @default.
- W2045792492 cites W2047850703 @default.
- W2045792492 cites W2053389892 @default.
- W2045792492 cites W2054192041 @default.
- W2045792492 cites W2054630261 @default.
- W2045792492 cites W2064677985 @default.
- W2045792492 cites W2065180218 @default.
- W2045792492 cites W206556109 @default.
- W2045792492 cites W2072075206 @default.
- W2045792492 cites W2072477927 @default.
- W2045792492 cites W2078173396 @default.
- W2045792492 cites W2082636822 @default.
- W2045792492 cites W2083801571 @default.
- W2045792492 cites W2085677897 @default.
- W2045792492 cites W2087335546 @default.
- W2045792492 cites W2089568026 @default.
- W2045792492 cites W2090950939 @default.
- W2045792492 cites W2097722577 @default.
- W2045792492 cites W2098128349 @default.
- W2045792492 cites W2103906844 @default.
- W2045792492 cites W2106908706 @default.
- W2045792492 cites W2107300216 @default.
- W2045792492 cites W2109916571 @default.
- W2045792492 cites W2112812444 @default.
- W2045792492 cites W2116523016 @default.
- W2045792492 cites W2117145783 @default.
- W2045792492 cites W2120783853 @default.
- W2045792492 cites W2127594582 @default.
- W2045792492 cites W2131322510 @default.
- W2045792492 cites W2135368579 @default.
- W2045792492 cites W2139133939 @default.
- W2045792492 cites W2142017357 @default.
- W2045792492 cites W2144937592 @default.
- W2045792492 cites W2148044949 @default.
- W2045792492 cites W2151075263 @default.
- W2045792492 cites W2157227966 @default.
- W2045792492 cites W2158592782 @default.
- W2045792492 cites W2164392903 @default.
- W2045792492 cites W2169128111 @default.
- W2045792492 cites W2409920052 @default.