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• W2045793196 abstract "Dysregulations of RNA A-to-I editing are associated with developmental defects in mouse and human diseases. Although several methods of identifying RNA A-to-I editing sites are currently available, most of the critical editing targets responsible for the important biological functions of adenosine deaminases that act on RNA (ADARs) remain unknown. Here we report a modified I-specific cleavage method that improves the quality of the RNA product. Preliminary microarray comparison of RNAs subjected to I-specific cleavage or mock digestion reported 165 genes that showed more than 0.2-fold reductions due to the cleavage. Six of the 165 genes were randomly selected for further verification, and three were verified to be targets of I-specific cleavage. This method may provide an alternative method of identifying novel RNA A-to-I editing sites using a microarray and facilitate the inquiry into the roles of RNA A-to-I editing in various biological processes." @default.
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• W2045793196 date "2012-12-27" @default.
• W2045793196 modified "2023-09-26" @default.
• W2045793196 title "RETRACTED: Inosine‐specific cleavage of RNA for microarray analysis of RNA A‐to‐I editing targets" @default.
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• W2045793196 doi "https://doi.org/10.1016/j.kjms.2012.08.031" @default.
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