Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045793286> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2045793286 endingPage "1828" @default.
- W2045793286 startingPage "1818" @default.
- W2045793286 abstract "Elevated levels of epidermal growth factor receptor (EGFR) have been detected in a variety of human cancers. Several reports have demonstrated that the Type III EGF receptor deletion-mutant (EGFRvIII) is frequently detected in various human cancers, including breast cancer. We generated and characterized monoclonal antibody against EGFRvIII. We demonstrated that 29% of DCIS, 40% of primary invasive breast cancers and 54% of metastatic lymph nodes express EGFRvIII by immunohistochemical analysis with two monoclonal antibodies. High levels of EGFRvIII expression were detected in about 5% of primary breast cancer and 27% of metastatic lymph-nodes. Furthermore, in the positive samples, the normal mammary gland exhibited negative staining for EGFRvIII, while the tumor cells were positive. The frequency of EGFRvIII expression correlated with breast cancer progression. We also showed that, despite the absence of gene amplification of EGFR in breast carcinoma cells, EGFRvIII was phosphorylated in breast cancer. In addition, approximately 40% of ErbB-2 positive primary breast tumors were found to co-express EGFRvIII. Even more striking is that 75% (3/4) of ErbB-2 positive metastatic lymph node specimens co-expressed with EGFRvIII. Co-expression of EGFRvIII with ErbB-2 in 32D cells amplified downstream signaling cascades and significantly enhanced tumorigenesis in vivo. Furthermore, EGFRvIII mediated constitutively activated and sustained downstream signaling pathways, whereas EGF-ligand induced a transient effect on wt-EGFR-mediated downstream signaling pathways." @default.
- W2045793286 created "2016-06-24" @default.
- W2045793286 creator A5020652253 @default.
- W2045793286 creator A5036291938 @default.
- W2045793286 creator A5037387785 @default.
- W2045793286 creator A5043106219 @default.
- W2045793286 creator A5047202249 @default.
- W2045793286 creator A5048301176 @default.
- W2045793286 creator A5069435197 @default.
- W2045793286 date "2008-11-01" @default.
- W2045793286 modified "2023-09-27" @default.
- W2045793286 title "Co-expression of EGFRvIII with ErbB-2 enhances tumorigenesis: EGFRvIII mediated constitutively activated and sustained signaling pathways, whereas EGF-induced a transient effect on EGFR-mediated signaling pathways" @default.
- W2045793286 doi "https://doi.org/10.4161/cbt.7.11.6847" @default.
- W2045793286 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18787418" @default.
- W2045793286 hasPublicationYear "2008" @default.
- W2045793286 type Work @default.
- W2045793286 sameAs 2045793286 @default.
- W2045793286 citedByCount "27" @default.
- W2045793286 countsByYear W20457932862012 @default.
- W2045793286 countsByYear W20457932862013 @default.
- W2045793286 countsByYear W20457932862014 @default.
- W2045793286 countsByYear W20457932862015 @default.
- W2045793286 countsByYear W20457932862016 @default.
- W2045793286 countsByYear W20457932862017 @default.
- W2045793286 countsByYear W20457932862019 @default.
- W2045793286 countsByYear W20457932862020 @default.
- W2045793286 countsByYear W20457932862021 @default.
- W2045793286 countsByYear W20457932862022 @default.
- W2045793286 countsByYear W20457932862023 @default.
- W2045793286 crossrefType "journal-article" @default.
- W2045793286 hasAuthorship W2045793286A5020652253 @default.
- W2045793286 hasAuthorship W2045793286A5036291938 @default.
- W2045793286 hasAuthorship W2045793286A5037387785 @default.
- W2045793286 hasAuthorship W2045793286A5043106219 @default.
- W2045793286 hasAuthorship W2045793286A5047202249 @default.
- W2045793286 hasAuthorship W2045793286A5048301176 @default.
- W2045793286 hasAuthorship W2045793286A5069435197 @default.
- W2045793286 hasBestOaLocation W20457932861 @default.
- W2045793286 hasConcept C121608353 @default.
- W2045793286 hasConcept C126322002 @default.
- W2045793286 hasConcept C159654299 @default.
- W2045793286 hasConcept C203014093 @default.
- W2045793286 hasConcept C204232928 @default.
- W2045793286 hasConcept C2779251935 @default.
- W2045793286 hasConcept C2779438470 @default.
- W2045793286 hasConcept C2780849966 @default.
- W2045793286 hasConcept C3018521938 @default.
- W2045793286 hasConcept C502942594 @default.
- W2045793286 hasConcept C530470458 @default.
- W2045793286 hasConcept C542903549 @default.
- W2045793286 hasConcept C555283112 @default.
- W2045793286 hasConcept C62478195 @default.
- W2045793286 hasConcept C71924100 @default.
- W2045793286 hasConcept C86803240 @default.
- W2045793286 hasConcept C95444343 @default.
- W2045793286 hasConceptScore W2045793286C121608353 @default.
- W2045793286 hasConceptScore W2045793286C126322002 @default.
- W2045793286 hasConceptScore W2045793286C159654299 @default.
- W2045793286 hasConceptScore W2045793286C203014093 @default.
- W2045793286 hasConceptScore W2045793286C204232928 @default.
- W2045793286 hasConceptScore W2045793286C2779251935 @default.
- W2045793286 hasConceptScore W2045793286C2779438470 @default.
- W2045793286 hasConceptScore W2045793286C2780849966 @default.
- W2045793286 hasConceptScore W2045793286C3018521938 @default.
- W2045793286 hasConceptScore W2045793286C502942594 @default.
- W2045793286 hasConceptScore W2045793286C530470458 @default.
- W2045793286 hasConceptScore W2045793286C542903549 @default.
- W2045793286 hasConceptScore W2045793286C555283112 @default.
- W2045793286 hasConceptScore W2045793286C62478195 @default.
- W2045793286 hasConceptScore W2045793286C71924100 @default.
- W2045793286 hasConceptScore W2045793286C86803240 @default.
- W2045793286 hasConceptScore W2045793286C95444343 @default.
- W2045793286 hasIssue "11" @default.
- W2045793286 hasLocation W20457932861 @default.
- W2045793286 hasLocation W20457932862 @default.
- W2045793286 hasOpenAccess W2045793286 @default.
- W2045793286 hasPrimaryLocation W20457932861 @default.
- W2045793286 hasRelatedWork W1499339123 @default.
- W2045793286 hasRelatedWork W2038791604 @default.
- W2045793286 hasRelatedWork W2071058106 @default.
- W2045793286 hasRelatedWork W2117059884 @default.
- W2045793286 hasRelatedWork W2150053835 @default.
- W2045793286 hasRelatedWork W2363637442 @default.
- W2045793286 hasRelatedWork W2385139574 @default.
- W2045793286 hasRelatedWork W2420962063 @default.
- W2045793286 hasRelatedWork W4307231259 @default.
- W2045793286 hasRelatedWork W4323808922 @default.
- W2045793286 hasVolume "7" @default.
- W2045793286 isParatext "false" @default.
- W2045793286 isRetracted "false" @default.
- W2045793286 magId "2045793286" @default.
- W2045793286 workType "article" @default.