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• W2045794616 abstract "Infection of rats with LCMV is known to cause a bi-phasic neurodegeneration characterized by acute T lymphocyte-mediated cerebellar damage, followed by gradual hippocampal neuron loss that occurs by an undefined mechanism. We found infiltration of CD8+ T-cells (but not CD4+ or NK cells) in the hippocampus which correlated with the acute phase, but not the chronic hippocampal degenerative phase. While immunosuppression of T lymphocytes protected the cerebellum and revealed the infection of corticohippocampal glia, the degeneration in the hippocampus was unabated. These data suggest that T lymphocytes control glial infection and mediate degeneration in the cerebellum but not the hippocampus." @default.
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• W2045794616 date "1999-11-01" @default.
• W2045794616 modified "2023-09-23" @default.
• W2045794616 title "Lymphocytic responses and the gradual hippocampal neuron loss following infection with lymphocytic choriomeningitis virus (LCMV)" @default.
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• W2045794616 doi "https://doi.org/10.1016/s0165-5728(99)00128-9" @default.
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