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• W2045798970 abstract "The function and properties of heterologously expressed full-length cDNA clones, isolated from a Taxus cDNA library and specific to Taxol biosynthesis, are summarized. Recombinant enzymes are described that catalyze early steps of the pathway, including taxadiene synthase, taxadien-5alpha-ol-O-acetyltransferase and taxadien-5alpha-yl acetate 10beta-hydroxylase, and that catalyze late steps, including 10-deacetylbaccatin III-10beta-O-acetyltransferase and taxane 2alpha-O-benzoyltransferase. The properties of Taxus geranylgeranyl diphosphate synthase are also described; although this synthase does not mediate a committed step of Taxol biosynthesis, it does provide the universal plastidial diterpenoid precursor, geranylgeranyl diphosphate, for initiating Taxol biosynthesis." @default.
• W2045798970 created "2016-06-24" @default.
• W2045798970 creator A5060790939 @default.
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• W2045798970 date "2001-09-01" @default.
• W2045798970 modified "2023-10-10" @default.
• W2045798970 title "Taxol biosynthetic genes" @default.
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• W2045798970 doi "https://doi.org/10.1016/s0031-9422(01)00160-1" @default.
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• W2045798970 hasPublicationYear "2001" @default.
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