FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045806619> ?p ?o ?g. }

• W2045806619 endingPage "1268" @default.
• W2045806619 startingPage "1262" @default.
• W2045806619 abstract "Monocytes participate in adaptive and innate immune responses. Monocyte numbers increase in patients with stroke associated infection (SAI) or severe stroke. Whether changes in monocytes are related to specific effects, or simply mark brain damage, remains unsettled.We used flow cytometry in 45 consecutive strokes and 12 healthy controls to assess the time course of monocytes, their phenotype, and the production of cytokines after stimulation. Cortisol, TNF-alpha, IFN-gamma, and IL-10 were measured in serum and metanephrine in plasma. The effects of humoral and cellular parameters on the risk of SAI and poor outcome were tested in multivariate analyses adjusted for confounders (NIHSS score, age, and tube feeding).Surface expression of human leukocyte antigen-DR, Toll-like receptor-2, and production of TNF-alpha in monocytes were independently associated with stroke. Distinct immune mechanisms were related with functional outcome and the risk of SAI; the signature of SAI included an increase of cortisol, metanephrine, and IL-10 in serum, and reduced production of TNF-alpha in monocytes; poor outcome was associated with increased expression of Toll-like receptor-4 in monocytes (OR, 9.61; 95% CI, 1.27-72.47). SAI did not predict poor outcome (OR, 5.63; 95% CI, 0.45-70.42; P=0.18).In human stroke, poor outcome is associated to innate responses mediated by Toll-like receptor-4 in monocytes. SAI may result from the immunosuppressive and antiinflammatory effects of corticoids, catecholamines, IL-10, and deactivated monocytes. Early treated SAI does not contribute significantly to additional brain damage. These findings encourage the exploration of strategies aimed to inhibit Toll-like receptor-4 signaling in acute stroke." @default.
• W2045806619 created "2016-06-24" @default.
• W2045806619 creator A5003196347 @default.
• W2045806619 creator A5025293617 @default.
• W2045806619 creator A5029711768 @default.
• W2045806619 creator A5045996029 @default.
• W2045806619 creator A5054210074 @default.
• W2045806619 creator A5073488277 @default.
• W2045806619 date "2009-04-01" @default.
• W2045806619 modified "2023-10-10" @default.
• W2045806619 title "Monocytes Are Major Players in the Prognosis and Risk of Infection After Acute Stroke" @default.
• W2045806619 cites W1481070238 @default.
• W2045806619 cites W1532205670 @default.
• W2045806619 cites W1622088669 @default.
• W2045806619 cites W186716551 @default.
• W2045806619 cites W1915121024 @default.
• W2045806619 cites W1970092944 @default.
• W2045806619 cites W1971560806 @default.
• W2045806619 cites W1985148630 @default.
• W2045806619 cites W1987643886 @default.
• W2045806619 cites W1995959583 @default.
• W2045806619 cites W2000819256 @default.
• W2045806619 cites W2004773897 @default.
• W2045806619 cites W2009887080 @default.
• W2045806619 cites W2017104717 @default.
• W2045806619 cites W2018683994 @default.
• W2045806619 cites W2020983205 @default.
• W2045806619 cites W2024494773 @default.
• W2045806619 cites W2029376832 @default.
• W2045806619 cites W2030097812 @default.
• W2045806619 cites W2036747221 @default.
• W2045806619 cites W2038689279 @default.
• W2045806619 cites W2045012389 @default.
• W2045806619 cites W2045098547 @default.
• W2045806619 cites W2054022839 @default.
• W2045806619 cites W2066908615 @default.
• W2045806619 cites W2068210940 @default.
• W2045806619 cites W2072870951 @default.
• W2045806619 cites W2085287265 @default.
• W2045806619 cites W2086667516 @default.
• W2045806619 cites W2088051625 @default.
• W2045806619 cites W2106380210 @default.
• W2045806619 cites W2108617074 @default.
• W2045806619 cites W2115623736 @default.
• W2045806619 cites W2119573232 @default.
• W2045806619 cites W2130518721 @default.
• W2045806619 cites W2131799206 @default.
• W2045806619 cites W2145736817 @default.
• W2045806619 cites W2146135936 @default.
• W2045806619 cites W2156751422 @default.
• W2045806619 cites W79466244 @default.
• W2045806619 doi "https://doi.org/10.1161/strokeaha.108.532085" @default.
• W2045806619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19164783" @default.
• W2045806619 hasPublicationYear "2009" @default.
• W2045806619 type Work @default.
• W2045806619 sameAs 2045806619 @default.
• W2045806619 citedByCount "158" @default.
• W2045806619 countsByYear W20458066192012 @default.
• W2045806619 countsByYear W20458066192013 @default.
• W2045806619 countsByYear W20458066192014 @default.
• W2045806619 countsByYear W20458066192015 @default.
• W2045806619 countsByYear W20458066192016 @default.
• W2045806619 countsByYear W20458066192017 @default.
• W2045806619 countsByYear W20458066192018 @default.
• W2045806619 countsByYear W20458066192019 @default.
• W2045806619 countsByYear W20458066192020 @default.
• W2045806619 countsByYear W20458066192021 @default.
• W2045806619 countsByYear W20458066192022 @default.
• W2045806619 countsByYear W20458066192023 @default.
• W2045806619 crossrefType "journal-article" @default.
• W2045806619 hasAuthorship W2045806619A5003196347 @default.
• W2045806619 hasAuthorship W2045806619A5025293617 @default.
• W2045806619 hasAuthorship W2045806619A5029711768 @default.
• W2045806619 hasAuthorship W2045806619A5045996029 @default.
• W2045806619 hasAuthorship W2045806619A5054210074 @default.
• W2045806619 hasAuthorship W2045806619A5073488277 @default.
• W2045806619 hasBestOaLocation W20458066191 @default.
• W2045806619 hasConcept C126322002 @default.
• W2045806619 hasConcept C127413603 @default.
• W2045806619 hasConcept C134018914 @default.
• W2045806619 hasConcept C136449434 @default.
• W2045806619 hasConcept C170493617 @default.
• W2045806619 hasConcept C17991360 @default.
• W2045806619 hasConcept C203014093 @default.
• W2045806619 hasConcept C2780645631 @default.
• W2045806619 hasConcept C2781184567 @default.
• W2045806619 hasConcept C71924100 @default.
• W2045806619 hasConcept C77350462 @default.
• W2045806619 hasConcept C78519656 @default.
• W2045806619 hasConcept C8891405 @default.
• W2045806619 hasConceptScore W2045806619C126322002 @default.
• W2045806619 hasConceptScore W2045806619C127413603 @default.
• W2045806619 hasConceptScore W2045806619C134018914 @default.
• W2045806619 hasConceptScore W2045806619C136449434 @default.
• W2045806619 hasConceptScore W2045806619C170493617 @default.
• W2045806619 hasConceptScore W2045806619C17991360 @default.
• W2045806619 hasConceptScore W2045806619C203014093 @default.
• W2045806619 hasConceptScore W2045806619C2780645631 @default.

• next