Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045807797> ?p ?o ?g. }
- W2045807797 endingPage "838" @default.
- W2045807797 startingPage "831" @default.
- W2045807797 abstract "The Niemann-Pick type C1 (NPC1) protein mediates the trafficking of cholesterol from lysosomes to other organelles. Mutations in the NPC1 gene lead to the retention of cholesterol and other lipids in the lysosomal compartment, and such defects are the basis of NPC disease. Several parallels exist between NPC disease and Alzheimer's disease (AD), including altered cholesterol homeostasis, changes in the lysosomal system, neurofibrillary tangles, and increased amyloid-beta generation. How the expression of NPC1 in the human brain is affected in AD has not been investigated so far. In the present study, we measured NPC1 mRNA and protein expression in three distinct regions of the human brain, and we revealed that NPC1 expression is upregulated at both mRNA and protein levels in the hippocampus and frontal cortex of AD patients compared to control individuals. In the cerebellum, a brain region that is relatively spared in AD, no difference in NPC1 expression was detected. Similarly, murine NPC1 mRNA levels were increased in the hippocampus of 12-month-old transgenic mice expressing a familial AD form of human amyloid-beta precursor protein (APP) and presenilin-1 (APP/PS1tg) compared to 12-month-old wild type mice, whereas no change in NPC1 was detected in mouse cerebellum. Immunohistochemical analysis of human hippocampus indicated that NPC1 expression was strongest in neurons. However, in vitro studies revealed that NPC1 expression was not induced by transfecting SK-N-SH neurons with human APP or by treating them with oligomeric amyloid-beta peptide. Total cholesterol levels were reduced in hippocampus from AD patients compared to control individuals, and it is therefore possible that the increased expression of NPC1 is linked to perturbed cholesterol homeostasis in AD." @default.
- W2045807797 created "2016-06-24" @default.
- W2045807797 creator A5000808429 @default.
- W2045807797 creator A5005760480 @default.
- W2045807797 creator A5019224352 @default.
- W2045807797 creator A5030922535 @default.
- W2045807797 creator A5042350144 @default.
- W2045807797 creator A5045441566 @default.
- W2045807797 creator A5047006862 @default.
- W2045807797 creator A5047141421 @default.
- W2045807797 creator A5088073146 @default.
- W2045807797 creator A5088991441 @default.
- W2045807797 date "2010-08-01" @default.
- W2045807797 modified "2023-09-27" @default.
- W2045807797 title "Increased expression of the lysosomal cholesterol transporter NPC1 in Alzheimer's disease" @default.
- W2045807797 cites W1487168219 @default.
- W2045807797 cites W1490301028 @default.
- W2045807797 cites W1536336594 @default.
- W2045807797 cites W1637989849 @default.
- W2045807797 cites W1965506696 @default.
- W2045807797 cites W1970541648 @default.
- W2045807797 cites W1972012989 @default.
- W2045807797 cites W1972914780 @default.
- W2045807797 cites W1974527814 @default.
- W2045807797 cites W1976059181 @default.
- W2045807797 cites W1978841341 @default.
- W2045807797 cites W1978993923 @default.
- W2045807797 cites W1979041069 @default.
- W2045807797 cites W1987562492 @default.
- W2045807797 cites W1991023072 @default.
- W2045807797 cites W2003908133 @default.
- W2045807797 cites W2004207208 @default.
- W2045807797 cites W2006825244 @default.
- W2045807797 cites W2010416572 @default.
- W2045807797 cites W2017254759 @default.
- W2045807797 cites W2017274978 @default.
- W2045807797 cites W2023120740 @default.
- W2045807797 cites W2028195118 @default.
- W2045807797 cites W2036362108 @default.
- W2045807797 cites W2041108499 @default.
- W2045807797 cites W2047210662 @default.
- W2045807797 cites W2047613132 @default.
- W2045807797 cites W2053057892 @default.
- W2045807797 cites W2055883416 @default.
- W2045807797 cites W2056194352 @default.
- W2045807797 cites W2057365200 @default.
- W2045807797 cites W2060610195 @default.
- W2045807797 cites W2064032283 @default.
- W2045807797 cites W2072099396 @default.
- W2045807797 cites W2076505784 @default.
- W2045807797 cites W2081586554 @default.
- W2045807797 cites W2082009186 @default.
- W2045807797 cites W2093296161 @default.
- W2045807797 cites W2099556509 @default.
- W2045807797 cites W2100491595 @default.
- W2045807797 cites W2105761603 @default.
- W2045807797 cites W2106192181 @default.
- W2045807797 cites W2110552397 @default.
- W2045807797 cites W2112222544 @default.
- W2045807797 cites W2113934386 @default.
- W2045807797 cites W2117857907 @default.
- W2045807797 cites W2126500773 @default.
- W2045807797 cites W2126528483 @default.
- W2045807797 cites W2131181742 @default.
- W2045807797 cites W2141367941 @default.
- W2045807797 cites W2142943752 @default.
- W2045807797 cites W2150999725 @default.
- W2045807797 cites W2154213419 @default.
- W2045807797 cites W2155041267 @default.
- W2045807797 cites W2159836929 @default.
- W2045807797 cites W2167115031 @default.
- W2045807797 cites W2171187981 @default.
- W2045807797 cites W2413388141 @default.
- W2045807797 doi "https://doi.org/10.1016/j.bbalip.2010.05.005" @default.
- W2045807797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20497909" @default.
- W2045807797 hasPublicationYear "2010" @default.
- W2045807797 type Work @default.
- W2045807797 sameAs 2045807797 @default.
- W2045807797 citedByCount "33" @default.
- W2045807797 countsByYear W20458077972012 @default.
- W2045807797 countsByYear W20458077972013 @default.
- W2045807797 countsByYear W20458077972014 @default.
- W2045807797 countsByYear W20458077972015 @default.
- W2045807797 countsByYear W20458077972016 @default.
- W2045807797 countsByYear W20458077972017 @default.
- W2045807797 countsByYear W20458077972018 @default.
- W2045807797 countsByYear W20458077972020 @default.
- W2045807797 countsByYear W20458077972021 @default.
- W2045807797 countsByYear W20458077972022 @default.
- W2045807797 crossrefType "journal-article" @default.
- W2045807797 hasAuthorship W2045807797A5000808429 @default.
- W2045807797 hasAuthorship W2045807797A5005760480 @default.
- W2045807797 hasAuthorship W2045807797A5019224352 @default.
- W2045807797 hasAuthorship W2045807797A5030922535 @default.
- W2045807797 hasAuthorship W2045807797A5042350144 @default.
- W2045807797 hasAuthorship W2045807797A5045441566 @default.
- W2045807797 hasAuthorship W2045807797A5047006862 @default.
- W2045807797 hasAuthorship W2045807797A5047141421 @default.