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- W2045807857 abstract "Movement in the Cancer Genome Transposable elements are genetic sequences that can replicate and move within the genome. The factors that make an element mobile are unknown but are generally considered rare in mammals. Lee et al. (p. 967 , published online 28 June) analyzed five cancer types occurring among several individuals and found that three types of epithelial tumors exhibited high rates of element movement relative to brain and blood cancers. Furthermore, these somatically acquired, tumor-specific elements targeted genes in colorectal cancer that, when disrupted, impact gene expression and thus may be a factor in the progression of the cancers." @default.
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- W2045807857 date "2012-08-24" @default.
- W2045807857 modified "2023-10-17" @default.
- W2045807857 title "Landscape of Somatic Retrotransposition in Human Cancers" @default.
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- W2045807857 doi "https://doi.org/10.1126/science.1222077" @default.
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