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• W2045807941 abstract "Summary Background Polymer‐free sirolimus‐ and probucol‐eluting stents ( R eal D ual drug‐eluting stents [ DES ]) is as effective as first‐generation DES in treating coronary artery stenosis. It is unknown whether sirolimus‐eluting stents containing biodegradable polymer ( E xcel) would be superior to real D ual DES . This study aimed to investigate the difference in target vessel revascularization ( TVR ) at 12 months in patients with coronary artery disease treated by the implantation of D ual D ES or Excel stents. Methods Three hundred and forty‐six patients with de novo coronary artery disease were recruited from six centers in China and randomly assigned to either the D ual D ES or the Excel group. The primary endpoint was the occurrence of TVR at 12 months. The secondary endpoint was angiographic in‐stent restenosis and late lumen loss at 13 months. Stent thrombosis ( ST ) served as the safety endpoint. Dual anti‐platelet therapy ( DAPT ) was prescribed for 6 months. Results Clinical follow‐up for 12 months and repeat angiography at 13 months were available in 100% and >90% of patients, respectively. The ISR and in‐stent late loss were significantly different between the E xcel (3.1%, 0.09 ± 0.11 mm) and the D ual D ES (19.5%, 0.36 ± 0.32 mm, P < 0.001, P < 0.001, respectively) groups. The TVR (3.5%) in the E xcel group was significantly less than in the D ual D ES group (13.9%, P = 0.001). The ST rate beyond 12 months in the D ual D ES group was 0%, and this was 1.2% in the E xcel group ( P = 0.499). Conclusions The E xcel stent was statistically superior to the D ual D ES in terms of restenosis, late loss, and TVR for long lesions." @default.
• W2045807941 created "2016-06-24" @default.
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• W2045807941 date "2013-07-18" @default.
• W2045807941 modified "2023-10-04" @default.
• W2045807941 title "Real Polymer-Free Sirolimus- and Probucol-Eluting Versus Biodegradable Polymer Sirolimus-Eluting Stents for Obstructive Coronary Artery Disease: DKPLUS-Wave 1, a Multicenter, Randomized, Prospective Trial" @default.
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• W2045807941 doi "https://doi.org/10.1111/j.1755-5922.2012.00319.x" @default.
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