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- W2045808910 abstract "The first synthesis of 5‘-dithiophosphoryl deoxyoligonucleotides is reported. These oligomers are prepared by reacting O-(9-fluorenemethyl) H-phosphonothioate with an appropriately protected deoxyoligonucleotide and then oxidizing phosphorus with elementary sulfur. By using 35S-sulfur, a long-lived radioactive isotope that is useful for monitoring biological and biochemical experiments can be introduced into deoxyoligonucleotides. 5‘-Dithiophosphoryl deoxyoligonucleotides are stable toward alkaline phosphatase and do not serve as substrates for T4-polynucleotide ligase. These oligomers undergo oxidative phosphoryl disulfide formation to yield dimers via an intermolecular reaction or with cysteine to generate an amino acid-deoxyoligonucleotide joined through the 5‘-dithiophosphoryl moiety and the cysteine sulfhydryl function." @default.
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- W2045808910 date "1996-01-01" @default.
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- W2045808910 title "5‘-Dithiophosphoryl Deoxyoligonucleotides: Synthesis and Biological Studies1" @default.
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- W2045808910 doi "https://doi.org/10.1021/ja961189a" @default.
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