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• W2045811917 startingPage "65" @default.
• W2045811917 abstract "In rat small mesenteric arteries, the influence of modulation of basal smooth muscle K+ efflux on the mechanism of endothelium-dependent hyperpolarization was investigated. The membrane potentials of the vascular smooth muscle cells were measured using conventional microelectrode techniques. Incubation of resting arteries with the gap junction uncoupler carbenoxolone (20 micro M) decreased the endothelium-dependent hyperpolarization elicited by a submaximal concentration of acetylcholine (3 micro M) to about 65% of the control. In the presence of Ba2+ (200 micro M), which depolarized the membrane potential by 10 mV, the acetylcholine-induced membrane potential response was doubled in magnitude, reaching values not different from control. Moreover, the hyperpolarization was more resistant to carbenoxolone in these conditions. Finally, both in the absence and in the presence of carbenoxolone, the combined application of Ba2+ and ouabain (0.5 mM) did not abolish the acetylcholine response. These results suggest that gap junctional coupling plays a role in endothelium-dependent hyperpolarization of smooth muscle cells of resting rat small mesenteric arteries. Additionally, these findings show that the hyperpolarization does not rely on activation of inward rectifying K+ channels. Although a minor contribution of Na-K pumping cannot be excluded, the Ba2+ experiments show that the membrane electrical response is mediated by activation of a Ba2+-resistant K+ conductance." @default.
• W2045811917 created "2016-06-24" @default.
• W2045811917 creator A5055610429 @default.
• W2045811917 creator A5066661239 @default.
• W2045811917 date "2004-01-01" @default.
• W2045811917 modified "2023-09-23" @default.
• W2045811917 title "Role of Ba2+-resistant K+ channels in endothelium-dependent hyperpolarization of rat small mesenteric arteries" @default.
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• W2045811917 doi "https://doi.org/10.1139/y03-132" @default.
• W2045811917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15052307" @default.
• W2045811917 hasPublicationYear "2004" @default.
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