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- W2045821289 abstract "Traditionally, human disorders were studied using animal models or somatic cells taken from patients. Such studies enabled the analysis of the molecular mechanisms of numerous disorders, and led to the discovery of new treatments. Yet, these systems are limited or even irrelevant in modeling multiple genetic diseases. The isolation of human embryonic stem cells (ESCs) from diseased blastocysts, the derivation of induced pluripotent stem cells (iPSCs) from patients’ somatic cells, and the new technologies for genome editing of pluripotent stem cells have opened a new window of opportunities in the field of disease modeling, and enabled studying diseases that couldn’t be modeled in the past. Importantly, despite the high similarity between ESCs and iPSCs, there are several fundamental differences between these cells, which have important implications regarding disease modeling. In this review we compare ESC-based models to iPSC-based models, and highlight the advantages and disadvantages of each system. We further suggest a roadmap for how to choose the optimal strategy to model each specific disorder." @default.
- W2045821289 created "2016-06-24" @default.
- W2045821289 creator A5051347191 @default.
- W2045821289 creator A5084311339 @default.
- W2045821289 date "2014-10-24" @default.
- W2045821289 modified "2023-10-04" @default.
- W2045821289 title "Comparing ESC and iPSC—Based Models for Human Genetic Disorders" @default.
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- W2045821289 cites W1981333258 @default.
- W2045821289 cites W1994536036 @default.
- W2045821289 cites W1996076770 @default.
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- W2045821289 cites W2035852054 @default.
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- W2045821289 doi "https://doi.org/10.3390/jcm3041146" @default.
- W2045821289 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4470175" @default.
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- W2045821289 hasPublicationYear "2014" @default.
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