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- W2045821566 abstract "Summary Canine peripheral blood lymphocytes (PBL) were stimulated with recombinant human interleukin‐2 (rhIL‐2) alone, or with phytohemagglutinin‐P (PHA) and subsequent rhIL‐2 in order to obtain large numbers of lymphokine‐activated killer (LAK) cells. Incubation of PBL with rhIL‐2 alone allowed proliferation of large granular lymphocyte (LGL)‐like lymphocytes, and the cytotoxic activity of the lymphocytes against canine transmissible venereal sarcoma cells was detected 5–7 days after the culture onset. However, the lymphocytes died within 2 weeks of culture, resulting in limited generation of functional LAK cells. Thus, PBL pretreated with PHA were subjected to rhIL‐2‐dependent culture. Small‐ or middle‐sized lymphocytes predominantly proliferated in response to rhIL‐2, and proliferation of the lymphocytes was sustained for longer than 30 days by repeated stimulations with PHA and subsequent rhIL‐2. Cytotoxicity reached significant levels from 2 weeks after the culture onset and thereafter remained almost constant for at least 2 weeks, leading to large‐scale production of the LAK cells. Pretreatment of PBL with PHA seems to enhance the LAK cell functions through modification of the precursors of the effector LAK cells." @default.
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- W2045821566 date "1996-02-12" @default.
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- W2045821566 title "Augmentative Effects of Phytohemagglutinin-P on Proliferation and Cytotoxicity of Interleukin-2-activated Canine Peripheral Blood Lymphocytes" @default.
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- W2045821566 doi "https://doi.org/10.1111/j.1439-0442.1996.tb00455.x" @default.
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