FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045830421> ?p ?o ?g. }

• W2045830421 endingPage "218" @default.
• W2045830421 startingPage "209" @default.
• W2045830421 abstract "Abstract Authors – Vunjak‐Novakovic G, Meinel L, Altman G, Kaplan D The clinical utility of tissue engineering depends upon our ability to direct cells to form tissues with characteristic structural and mechanical properties across different hierarchical scales. Ideally, an engineered graft should be tailored to (re)establish the structure and function of the native tissue being replaced. Engineered grafts of such high fidelity would also foster fundamental research by serving as physiologically relevant models for quantitative in vitro studies. The approach discussed here involves the use of human mesenchymal stem cells (hMSC) cultured on custom‐designed scaffolds (providing a structural and logistic template for tissue development) in bioreactors (providing environmental control, biochemical and mechanical cues). Cartilage, bone and ligaments have been engineered by using hMSC, highly porous protein scaffolds (collagen; silk) and bioreactors (perfused cartridges with or without mechanical loading). In each case, the scaffold and bioreactor were designed to recapitulate some aspects of the environment present in native tissues. Medium flow facilitated mass transport to the cells and thereby enhanced the formation of all three tissues. In the case of cartilage, dynamic laminar flow patterns were advantageous as compared to either turbulent steady flow or static (no flow) cultures. In the case of bone, medium flow affected the geometry, distribution and orientation of the forming bone‐like trabeculae. In the case of ligament, applied mechanical loading (a combination of dynamic stretch and torsion) markedly enhanced cell differentiation, alignment and functional assembly. Taken together, these studies provide a basis for the ongoing work on engineering osreochondral grafts for a variety of potential applications, including those in the craniofacial complex." @default.
• W2045830421 created "2016-06-24" @default.
• W2045830421 creator A5001051737 @default.
• W2045830421 creator A5009146522 @default.
• W2045830421 creator A5044928451 @default.
• W2045830421 creator A5057871048 @default.
• W2045830421 date "2005-07-15" @default.
• W2045830421 modified "2023-10-16" @default.
• W2045830421 title "Bioreactor cultivation of osteochondral grafts" @default.
• W2045830421 cites W1511710138 @default.
• W2045830421 cites W1601381175 @default.
• W2045830421 cites W1964640087 @default.
• W2045830421 cites W1966226890 @default.
• W2045830421 cites W1978619076 @default.
• W2045830421 cites W1986867932 @default.
• W2045830421 cites W1995091382 @default.
• W2045830421 cites W2009350275 @default.
• W2045830421 cites W2015136889 @default.
• W2045830421 cites W2022825927 @default.
• W2045830421 cites W2034607468 @default.
• W2045830421 cites W2037570346 @default.
• W2045830421 cites W2038530539 @default.
• W2045830421 cites W2040576195 @default.
• W2045830421 cites W2040689386 @default.
• W2045830421 cites W2048545017 @default.
• W2045830421 cites W2059442046 @default.
• W2045830421 cites W2070887869 @default.
• W2045830421 cites W2075130086 @default.
• W2045830421 cites W2081312806 @default.
• W2045830421 cites W2099635527 @default.
• W2045830421 cites W2105057096 @default.
• W2045830421 cites W2123349384 @default.
• W2045830421 cites W2131456542 @default.
• W2045830421 cites W2133884616 @default.
• W2045830421 cites W2136899344 @default.
• W2045830421 cites W2147526125 @default.
• W2045830421 cites W2152723687 @default.
• W2045830421 cites W2156001590 @default.
• W2045830421 cites W2157908104 @default.
• W2045830421 cites W2160253249 @default.
• W2045830421 cites W2166647329 @default.
• W2045830421 cites W2171226607 @default.
• W2045830421 cites W2910513247 @default.
• W2045830421 doi "https://doi.org/10.1111/j.1601-6343.2005.00334.x" @default.
• W2045830421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16022723" @default.
• W2045830421 hasPublicationYear "2005" @default.
• W2045830421 type Work @default.
• W2045830421 sameAs 2045830421 @default.
• W2045830421 citedByCount "110" @default.
• W2045830421 countsByYear W20458304212012 @default.
• W2045830421 countsByYear W20458304212013 @default.
• W2045830421 countsByYear W20458304212014 @default.
• W2045830421 countsByYear W20458304212015 @default.
• W2045830421 countsByYear W20458304212016 @default.
• W2045830421 countsByYear W20458304212017 @default.
• W2045830421 countsByYear W20458304212018 @default.
• W2045830421 countsByYear W20458304212019 @default.
• W2045830421 countsByYear W20458304212020 @default.
• W2045830421 countsByYear W20458304212021 @default.
• W2045830421 countsByYear W20458304212023 @default.
• W2045830421 crossrefType "journal-article" @default.
• W2045830421 hasAuthorship W2045830421A5001051737 @default.
• W2045830421 hasAuthorship W2045830421A5009146522 @default.
• W2045830421 hasAuthorship W2045830421A5044928451 @default.
• W2045830421 hasAuthorship W2045830421A5057871048 @default.
• W2045830421 hasConcept C105702510 @default.
• W2045830421 hasConcept C127413603 @default.
• W2045830421 hasConcept C136229726 @default.
• W2045830421 hasConcept C168170006 @default.
• W2045830421 hasConcept C178790620 @default.
• W2045830421 hasConcept C185592680 @default.
• W2045830421 hasConcept C192562407 @default.
• W2045830421 hasConcept C198826908 @default.
• W2045830421 hasConcept C2780550940 @default.
• W2045830421 hasConcept C49892992 @default.
• W2045830421 hasConcept C86803240 @default.
• W2045830421 hasConcept C89429830 @default.
• W2045830421 hasConcept C95444343 @default.
• W2045830421 hasConceptScore W2045830421C105702510 @default.
• W2045830421 hasConceptScore W2045830421C127413603 @default.
• W2045830421 hasConceptScore W2045830421C136229726 @default.
• W2045830421 hasConceptScore W2045830421C168170006 @default.
• W2045830421 hasConceptScore W2045830421C178790620 @default.
• W2045830421 hasConceptScore W2045830421C185592680 @default.
• W2045830421 hasConceptScore W2045830421C192562407 @default.
• W2045830421 hasConceptScore W2045830421C198826908 @default.
• W2045830421 hasConceptScore W2045830421C2780550940 @default.
• W2045830421 hasConceptScore W2045830421C49892992 @default.
• W2045830421 hasConceptScore W2045830421C86803240 @default.
• W2045830421 hasConceptScore W2045830421C89429830 @default.
• W2045830421 hasConceptScore W2045830421C95444343 @default.
• W2045830421 hasIssue "3" @default.
• W2045830421 hasLocation W20458304211 @default.
• W2045830421 hasLocation W20458304212 @default.
• W2045830421 hasOpenAccess W2045830421 @default.
• W2045830421 hasPrimaryLocation W20458304211 @default.
• W2045830421 hasRelatedWork W1847492452 @default.
• W2045830421 hasRelatedWork W2100993833 @default.

• next