FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045837031> ?p ?o ?g. }

• W2045837031 endingPage "e46" @default.
• W2045837031 startingPage "e46" @default.
• W2045837031 abstract "A better understanding of the processes influencing energy expenditure could provide new therapeutic strategies for reducing obesity. As the metabolic activity of the brown adipose tissue (BAT) and skeletal muscle is an important determinant of overall energy expenditure and adiposity, we investigated the role of genes that could influence cellular bioenergetics in these two tissues. We screened for genes that are induced in both the BAT and skeletal muscle during acute adaptive thermogenesis in the mouse by microarray. We used C57BL/6J mice as well as the primary and immortalized brown adipocytes and C2C12 myocytes to validate the microarray data. Further characterization included gene expression, mitochondrial density, cellular respiration and substrate utilization. We also used a Hybrid Mouse Diversity Panel to assess in vivo effects on obesity and body fat content. We identified the transcription factor Zbtb16 (also known as Plzf and Zfp14) as being induced in both the BAT and skeletal muscle during acute adaptive thermogenesis. Zbtb16 overexpression in brown adipocytes led to the induction of components of the thermogenic program, including genes involved in fatty acid oxidation, glycolysis and mitochondrial function. Enhanced Zbtb16 expression also increased mitochondrial number, as well as the respiratory capacity and uncoupling. These effects were accompanied by decreased triglyceride content and increased carbohydrate utilization in brown adipocytes. Natural variation in Zbtb16 mRNA levels in multiple tissues across a panel of >100 mouse strains was inversely correlated with body weight and body fat content. Our results implicate Zbtb16 as a novel determinant of substrate utilization in brown adipocytes and of adiposity in vivo." @default.
• W2045837031 created "2016-06-24" @default.
• W2045837031 creator A5000921774 @default.
• W2045837031 creator A5007515465 @default.
• W2045837031 creator A5019944871 @default.
• W2045837031 creator A5024741961 @default.
• W2045837031 creator A5039639551 @default.
• W2045837031 creator A5074006758 @default.
• W2045837031 creator A5079909478 @default.
• W2045837031 date "2012-09-17" @default.
• W2045837031 modified "2023-10-16" @default.
• W2045837031 title "Zbtb16 has a role in brown adipocyte bioenergetics" @default.
• W2045837031 cites W1489169196 @default.
• W2045837031 cites W1965079305 @default.
• W2045837031 cites W1968963111 @default.
• W2045837031 cites W1977825177 @default.
• W2045837031 cites W1982766384 @default.
• W2045837031 cites W1983438848 @default.
• W2045837031 cites W1993133030 @default.
• W2045837031 cites W1994439048 @default.
• W2045837031 cites W1996039273 @default.
• W2045837031 cites W2005827500 @default.
• W2045837031 cites W2008632158 @default.
• W2045837031 cites W2009297239 @default.
• W2045837031 cites W2012071760 @default.
• W2045837031 cites W2029874037 @default.
• W2045837031 cites W2042194402 @default.
• W2045837031 cites W2046859247 @default.
• W2045837031 cites W2050132057 @default.
• W2045837031 cites W2056883894 @default.
• W2045837031 cites W2057337991 @default.
• W2045837031 cites W2058590472 @default.
• W2045837031 cites W2077132863 @default.
• W2045837031 cites W2085250950 @default.
• W2045837031 cites W2091614510 @default.
• W2045837031 cites W2093013657 @default.
• W2045837031 cites W2098080779 @default.
• W2045837031 cites W2098457930 @default.
• W2045837031 cites W2106004899 @default.
• W2045837031 cites W2107926446 @default.
• W2045837031 cites W2109665403 @default.
• W2045837031 cites W2111514839 @default.
• W2045837031 cites W2117007075 @default.
• W2045837031 cites W2123371309 @default.
• W2045837031 cites W2127749087 @default.
• W2045837031 cites W2132358997 @default.
• W2045837031 cites W2143070830 @default.
• W2045837031 cites W2146625096 @default.
• W2045837031 cites W2149540190 @default.
• W2045837031 cites W2150419930 @default.
• W2045837031 cites W2158534900 @default.
• W2045837031 cites W2162523749 @default.
• W2045837031 cites W2319352353 @default.
• W2045837031 cites W2322323638 @default.
• W2045837031 cites W2336343654 @default.
• W2045837031 doi "https://doi.org/10.1038/nutd.2012.21" @default.
• W2045837031 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3461357" @default.
• W2045837031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23446662" @default.
• W2045837031 hasPublicationYear "2012" @default.
• W2045837031 type Work @default.
• W2045837031 sameAs 2045837031 @default.
• W2045837031 citedByCount "48" @default.
• W2045837031 countsByYear W20458370312013 @default.
• W2045837031 countsByYear W20458370312014 @default.
• W2045837031 countsByYear W20458370312015 @default.
• W2045837031 countsByYear W20458370312016 @default.
• W2045837031 countsByYear W20458370312017 @default.
• W2045837031 countsByYear W20458370312018 @default.
• W2045837031 countsByYear W20458370312019 @default.
• W2045837031 countsByYear W20458370312020 @default.
• W2045837031 countsByYear W20458370312021 @default.
• W2045837031 countsByYear W20458370312022 @default.
• W2045837031 countsByYear W20458370312023 @default.
• W2045837031 crossrefType "journal-article" @default.
• W2045837031 hasAuthorship W2045837031A5000921774 @default.
• W2045837031 hasAuthorship W2045837031A5007515465 @default.
• W2045837031 hasAuthorship W2045837031A5019944871 @default.
• W2045837031 hasAuthorship W2045837031A5024741961 @default.
• W2045837031 hasAuthorship W2045837031A5039639551 @default.
• W2045837031 hasAuthorship W2045837031A5074006758 @default.
• W2045837031 hasAuthorship W2045837031A5079909478 @default.
• W2045837031 hasBestOaLocation W20458370311 @default.
• W2045837031 hasConcept C100206155 @default.
• W2045837031 hasConcept C126322002 @default.
• W2045837031 hasConcept C134018914 @default.
• W2045837031 hasConcept C151279926 @default.
• W2045837031 hasConcept C171089720 @default.
• W2045837031 hasConcept C2779959927 @default.
• W2045837031 hasConcept C2780642333 @default.
• W2045837031 hasConcept C28859421 @default.
• W2045837031 hasConcept C71924100 @default.
• W2045837031 hasConcept C81979416 @default.
• W2045837031 hasConcept C86803240 @default.
• W2045837031 hasConcept C95444343 @default.
• W2045837031 hasConceptScore W2045837031C100206155 @default.
• W2045837031 hasConceptScore W2045837031C126322002 @default.
• W2045837031 hasConceptScore W2045837031C134018914 @default.
• W2045837031 hasConceptScore W2045837031C151279926 @default.

• next