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- W2045845071 abstract "Abstract Release of D&C Yellow No. 10 and anhydrous theophylline have been determined from a thermosoftening, hydrophilic matrix, Gelucire 50/13, incorporating a water-soluble additive, polyethylene glycol 4000. As additive level increased, release also increased. The effect of mixtures of Gelucire 50/13 (G50/13) and Gelucire 50/02 (G50/02) on release was also investigated as a function of temperature and pH. As the level of G50/02 increased, release decreased and became predominantly diffusional. As temperature was increased, release changed from diffusion to a mixed model of both diffusion and erosion. At basic pH, release from these composite systems became more erosional in character, possibly reflecting partial hydrolysis of the ester-linked matrices. Diffusion coefficients and apparent diffusion coefficients were calculated in G50/02 and G50/13 matrices, respectively, and were in agreement with published data." @default.
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- W2045845071 date "1991-06-01" @default.
- W2045845071 modified "2023-10-18" @default.
- W2045845071 title "Evaluation of Release from Selected Thermosoftening Vehicles" @default.
- W2045845071 cites W1511449683 @default.
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- W2045845071 doi "https://doi.org/10.1111/j.2042-7158.1991.tb03493.x" @default.
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