FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045847046> ?p ?o ?g. }

• W2045847046 endingPage "1135" @default.
• W2045847046 startingPage "1128" @default.
• W2045847046 abstract "Endometrial decidualization and associated extracellular matrix (ECM) remodeling are critical events to the establishment of the maternal–fetal interface and successful pregnancy. Here, we investigated the impact of type 1 diabetes on these processes during early embryonic development, in order to contribute to the understanding of the maternal factors associated to diabetic embryopathies. Alloxan-induced diabetic Swiss female mice were bred after different periods of time to determine the effects of diabetes progression on the development of gestational complications. Furthermore, the analyses focused on decidual development as well as mRNA expression, protein deposition and ultrastructural organization of decidual ECM. Decreased number of implantation sites and decidual dimensions were observed in the group mated 90–110 days after diabetes induction (D), but not in the 50–70D group. Picrosirius staining showed augmentation in the fibrillar collagen network in the 90–110D group and, following immunohistochemical examination, that this was associated with increase in types I and V collagens and decrease in type III collagen and collagen-associated proteoglycans biglycan and lumican. qPCR, however, demonstrated that only type I collagen mRNA levels were increased in the diabetic group. Alterations in the molecular ratio among distinct collagen types and proteoglycans were associated with abnormal collagen fibrillogenesis, analyzed by transmission electron microscopy. Our results support the concept that the development of pregnancy complications is directly related with duration of diabetes (progression of the disease), and that this is a consequence of both systemic factors (i.e. disturbed maternal endocrine–metabolic profile) and uterine factors, including impaired decidualization and ECM remodeling." @default.
• W2045847046 created "2016-06-24" @default.
• W2045847046 creator A5006225450 @default.
• W2045847046 creator A5011046896 @default.
• W2045847046 creator A5037565439 @default.
• W2045847046 creator A5041212822 @default.
• W2045847046 creator A5051291219 @default.
• W2045847046 creator A5054163001 @default.
• W2045847046 creator A5063062349 @default.
• W2045847046 date "2013-12-01" @default.
• W2045847046 modified "2023-09-26" @default.
• W2045847046 title "Long-term type 1 diabetes impairs decidualization and extracellular matrix remodeling during early embryonic development in mice" @default.
• W2045847046 cites W1532628373 @default.
• W2045847046 cites W1697684369 @default.
• W2045847046 cites W1869980086 @default.
• W2045847046 cites W1917942675 @default.
• W2045847046 cites W1965408397 @default.
• W2045847046 cites W1992279132 @default.
• W2045847046 cites W1993567531 @default.
• W2045847046 cites W1996519016 @default.
• W2045847046 cites W2005252107 @default.
• W2045847046 cites W2010817650 @default.
• W2045847046 cites W2020330132 @default.
• W2045847046 cites W2026971498 @default.
• W2045847046 cites W2030933918 @default.
• W2045847046 cites W2050546960 @default.
• W2045847046 cites W2052164094 @default.
• W2045847046 cites W2052823936 @default.
• W2045847046 cites W2058804921 @default.
• W2045847046 cites W2063828552 @default.
• W2045847046 cites W2070013317 @default.
• W2045847046 cites W2076569607 @default.
• W2045847046 cites W2080849406 @default.
• W2045847046 cites W2086855373 @default.
• W2045847046 cites W2087513468 @default.
• W2045847046 cites W2088021754 @default.
• W2045847046 cites W2089574035 @default.
• W2045847046 cites W2109469421 @default.
• W2045847046 cites W2117326627 @default.
• W2045847046 cites W2121357257 @default.
• W2045847046 cites W2130642100 @default.
• W2045847046 cites W2131657077 @default.
• W2045847046 cites W2141040886 @default.
• W2045847046 cites W2142403309 @default.
• W2045847046 cites W2144032368 @default.
• W2045847046 cites W2145632357 @default.
• W2045847046 cites W2160006574 @default.
• W2045847046 cites W2160502065 @default.
• W2045847046 cites W2325234488 @default.
• W2045847046 cites W2410125730 @default.
• W2045847046 cites W2769264260 @default.
• W2045847046 doi "https://doi.org/10.1016/j.placenta.2013.09.012" @default.
• W2045847046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24125804" @default.
• W2045847046 hasPublicationYear "2013" @default.
• W2045847046 type Work @default.
• W2045847046 sameAs 2045847046 @default.
• W2045847046 citedByCount "21" @default.
• W2045847046 countsByYear W20458470462014 @default.
• W2045847046 countsByYear W20458470462015 @default.
• W2045847046 countsByYear W20458470462016 @default.
• W2045847046 countsByYear W20458470462017 @default.
• W2045847046 countsByYear W20458470462019 @default.
• W2045847046 countsByYear W20458470462020 @default.
• W2045847046 countsByYear W20458470462022 @default.
• W2045847046 crossrefType "journal-article" @default.
• W2045847046 hasAuthorship W2045847046A5006225450 @default.
• W2045847046 hasAuthorship W2045847046A5011046896 @default.
• W2045847046 hasAuthorship W2045847046A5037565439 @default.
• W2045847046 hasAuthorship W2045847046A5041212822 @default.
• W2045847046 hasAuthorship W2045847046A5051291219 @default.
• W2045847046 hasAuthorship W2045847046A5054163001 @default.
• W2045847046 hasAuthorship W2045847046A5063062349 @default.
• W2045847046 hasBestOaLocation W20458470461 @default.
• W2045847046 hasConcept C126322002 @default.
• W2045847046 hasConcept C134018914 @default.
• W2045847046 hasConcept C16685009 @default.
• W2045847046 hasConcept C189165786 @default.
• W2045847046 hasConcept C2778316770 @default.
• W2045847046 hasConcept C2778916964 @default.
• W2045847046 hasConcept C2779335624 @default.
• W2045847046 hasConcept C2779742232 @default.
• W2045847046 hasConcept C2779794767 @default.
• W2045847046 hasConcept C2780644872 @default.
• W2045847046 hasConcept C38008103 @default.
• W2045847046 hasConcept C71924100 @default.
• W2045847046 hasConcept C86803240 @default.
• W2045847046 hasConcept C95444343 @default.
• W2045847046 hasConceptScore W2045847046C126322002 @default.
• W2045847046 hasConceptScore W2045847046C134018914 @default.
• W2045847046 hasConceptScore W2045847046C16685009 @default.
• W2045847046 hasConceptScore W2045847046C189165786 @default.
• W2045847046 hasConceptScore W2045847046C2778316770 @default.
• W2045847046 hasConceptScore W2045847046C2778916964 @default.
• W2045847046 hasConceptScore W2045847046C2779335624 @default.
• W2045847046 hasConceptScore W2045847046C2779742232 @default.
• W2045847046 hasConceptScore W2045847046C2779794767 @default.
• W2045847046 hasConceptScore W2045847046C2780644872 @default.
• W2045847046 hasConceptScore W2045847046C38008103 @default.

• next