Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045850003> ?p ?o ?g. }
- W2045850003 endingPage "158" @default.
- W2045850003 startingPage "151" @default.
- W2045850003 abstract "Aim: This study was designed to determine the effects of intraperitoneally or orally administered N-acetylcysteine (NAC) on anastomotic healing of irradiated rats. Methods: Thirty-two male Wistar albino rats were randomized into four groups containing 8 rats each: I; standard resection plus anastomosis, II; radiation plus standard resection plus anastomosis, III; radiation plus standard resection plus anastomosis plus oral NAC, IV; radiation plus standard resection plus anastomosis plus intraperitoneal NAC. Four types of assessment were performed: bursting pressure, hydroxiproline (OHP) content, histopathology, and biochemical evaluation, including serum malondialdehyde (MDA), advanced oxidation protein products (AOPP), reduced glutathione (GSH) and superoxide dismutase (SOD) activities. Results: Group comparisons demonstrated that bursting pressure was significantly higher in NAC treated rats. The mean tissue OHP concentration in the anastomotic tissue was significantly lower in irradiated rats (group II) than in the other groups. NAC treatment caused increased activity of SOD and GSH. In contrast, MDA levels were found to be decreased in groups III and IV. Histopathological analysis revealed that NAC administration, either orally or intraperitoneally, leads to a better anastomotic healing in terms of reepithelialization, perianastomotic fibrosis, ischemic necrosis, and muscle layer destruction. Conclusion: The present study supports the hypothesis that NAC administration alleviates the negative effects of radiotherapy on anastomotic healing. Nevertheless, the underlying mechanisms responsible for this protective effect is unknown today." @default.
- W2045850003 created "2016-06-24" @default.
- W2045850003 creator A5009837332 @default.
- W2045850003 creator A5028863597 @default.
- W2045850003 creator A5034618170 @default.
- W2045850003 creator A5036858212 @default.
- W2045850003 creator A5046552940 @default.
- W2045850003 creator A5062990977 @default.
- W2045850003 creator A5073254434 @default.
- W2045850003 date "2011-06-15" @default.
- W2045850003 modified "2023-10-14" @default.
- W2045850003 title "N-Acetyl-Cysteine Improves Anastomotic Wound Healing after Radiotherapy in Rats" @default.
- W2045850003 cites W1575245978 @default.
- W2045850003 cites W1969239307 @default.
- W2045850003 cites W1978388575 @default.
- W2045850003 cites W1981602190 @default.
- W2045850003 cites W1982406043 @default.
- W2045850003 cites W1990594485 @default.
- W2045850003 cites W2006370393 @default.
- W2045850003 cites W2008340939 @default.
- W2045850003 cites W2010990674 @default.
- W2045850003 cites W2013981701 @default.
- W2045850003 cites W2018261849 @default.
- W2045850003 cites W2019032615 @default.
- W2045850003 cites W2026368277 @default.
- W2045850003 cites W2031113155 @default.
- W2045850003 cites W2040854368 @default.
- W2045850003 cites W2043773984 @default.
- W2045850003 cites W2044199111 @default.
- W2045850003 cites W2046519577 @default.
- W2045850003 cites W2059699981 @default.
- W2045850003 cites W2062356491 @default.
- W2045850003 cites W2063608959 @default.
- W2045850003 cites W2069603964 @default.
- W2045850003 cites W2074391555 @default.
- W2045850003 cites W2075430916 @default.
- W2045850003 cites W2092085059 @default.
- W2045850003 cites W2100987057 @default.
- W2045850003 cites W2111376662 @default.
- W2045850003 cites W2112682437 @default.
- W2045850003 cites W2123965103 @default.
- W2045850003 cites W2143108876 @default.
- W2045850003 cites W2148488239 @default.
- W2045850003 cites W2159305277 @default.
- W2045850003 cites W2164695375 @default.
- W2045850003 cites W4250463418 @default.
- W2045850003 doi "https://doi.org/10.3109/08941939.2011.560237" @default.
- W2045850003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21675850" @default.
- W2045850003 hasPublicationYear "2011" @default.
- W2045850003 type Work @default.
- W2045850003 sameAs 2045850003 @default.
- W2045850003 citedByCount "22" @default.
- W2045850003 countsByYear W20458500032012 @default.
- W2045850003 countsByYear W20458500032013 @default.
- W2045850003 countsByYear W20458500032014 @default.
- W2045850003 countsByYear W20458500032015 @default.
- W2045850003 countsByYear W20458500032016 @default.
- W2045850003 countsByYear W20458500032017 @default.
- W2045850003 countsByYear W20458500032018 @default.
- W2045850003 countsByYear W20458500032019 @default.
- W2045850003 countsByYear W20458500032020 @default.
- W2045850003 countsByYear W20458500032021 @default.
- W2045850003 crossrefType "journal-article" @default.
- W2045850003 hasAuthorship W2045850003A5009837332 @default.
- W2045850003 hasAuthorship W2045850003A5028863597 @default.
- W2045850003 hasAuthorship W2045850003A5034618170 @default.
- W2045850003 hasAuthorship W2045850003A5036858212 @default.
- W2045850003 hasAuthorship W2045850003A5046552940 @default.
- W2045850003 hasAuthorship W2045850003A5062990977 @default.
- W2045850003 hasAuthorship W2045850003A5073254434 @default.
- W2045850003 hasConcept C126322002 @default.
- W2045850003 hasConcept C141071460 @default.
- W2045850003 hasConcept C142724271 @default.
- W2045850003 hasConcept C181199279 @default.
- W2045850003 hasConcept C185592680 @default.
- W2045850003 hasConcept C2775838275 @default.
- W2045850003 hasConcept C2776151105 @default.
- W2045850003 hasConcept C2777056448 @default.
- W2045850003 hasConcept C2777847592 @default.
- W2045850003 hasConcept C2778004101 @default.
- W2045850003 hasConcept C2778401633 @default.
- W2045850003 hasConcept C2780269544 @default.
- W2045850003 hasConcept C2780559512 @default.
- W2045850003 hasConcept C503630168 @default.
- W2045850003 hasConcept C509974204 @default.
- W2045850003 hasConcept C538909803 @default.
- W2045850003 hasConcept C544855455 @default.
- W2045850003 hasConcept C55493867 @default.
- W2045850003 hasConcept C71924100 @default.
- W2045850003 hasConcept C8443397 @default.
- W2045850003 hasConcept C90924648 @default.
- W2045850003 hasConcept C98274493 @default.
- W2045850003 hasConceptScore W2045850003C126322002 @default.
- W2045850003 hasConceptScore W2045850003C141071460 @default.
- W2045850003 hasConceptScore W2045850003C142724271 @default.
- W2045850003 hasConceptScore W2045850003C181199279 @default.
- W2045850003 hasConceptScore W2045850003C185592680 @default.
- W2045850003 hasConceptScore W2045850003C2775838275 @default.