Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045851208> ?p ?o ?g. }
- W2045851208 endingPage "287" @default.
- W2045851208 startingPage "277" @default.
- W2045851208 abstract "The metabolic fate of nitric oxide (NO) released from nitroaspirin, benzoic acid, 2-(acetyloxy)-3-[(nitrooxy)methyl]phenyl ester (NCX 4016), the lead compound of a new class of NO-releasing non-steroidal anti-inflammatory drugs (NO-NSAIDs) has been studied in eight healthy male Caucasian subjects following p.o. administration of 1600 mg (single dose), by monitoring at different times in plasma the bioactive storage forms of NO, S-nitrosothiols (RSNO) and its oxidation products (NOx). Plasma levels of NOx and RSNO and urinary levels of NOx were determined by an ozone-based chemiluminescent assay using a sensitive Nitric Oxide Analyzer (LOQ: 10 pmol NO injected). In parallel plasma samples were analyzed by a newly developed LC–MS/MS method for analysis of NCX 4015, the metabolite bearing the nitrate ester function. Using MS/MS with multiple reaction monitoring (MRM) in negative ion mode for NCX 4015 and the internal standard (NCX 4015-13C-D2) it was possible to detect with sufficient accuracy and precision the metabolite in plasma with a quantification limit of 78.1 ng ml−1. Concentration versus time profile of plasma NCX 4015 gave a Cmax value of 161.94±47.4 ng ml−1 and a tmax 4.5±1 h. The results indicate that both NOx and RSNO (these last for the first time determined in vivo in man following oral administration of a NO-donor drug) are effective plasma markers of NO release in vivo, the latter being an earlier indicator of NO distribution (tmax 2.0±0.6 h versus 5.4±1.2 h)." @default.
- W2045851208 created "2016-06-24" @default.
- W2045851208 creator A5001799610 @default.
- W2045851208 creator A5008682550 @default.
- W2045851208 creator A5015361221 @default.
- W2045851208 creator A5019484257 @default.
- W2045851208 creator A5079645996 @default.
- W2045851208 creator A5090581943 @default.
- W2045851208 date "2004-04-01" @default.
- W2045851208 modified "2023-10-04" @default.
- W2045851208 title "Chemiluminescence and LC–MS/MS analyses for the study of nitric oxide release and distribution following oral administration of nitroaspirin (NCX 4016) in healthy volunteers" @default.
- W2045851208 cites W1553766496 @default.
- W2045851208 cites W1909194257 @default.
- W2045851208 cites W1980155504 @default.
- W2045851208 cites W1990594604 @default.
- W2045851208 cites W2013628401 @default.
- W2045851208 cites W2024417244 @default.
- W2045851208 cites W2026117623 @default.
- W2045851208 cites W2027439180 @default.
- W2045851208 cites W2032825410 @default.
- W2045851208 cites W2037568430 @default.
- W2045851208 cites W2058672630 @default.
- W2045851208 cites W2076352079 @default.
- W2045851208 cites W2087271151 @default.
- W2045851208 cites W2087833812 @default.
- W2045851208 cites W2146898912 @default.
- W2045851208 cites W2160359747 @default.
- W2045851208 doi "https://doi.org/10.1016/s0731-7085(03)00531-4" @default.
- W2045851208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15063462" @default.
- W2045851208 hasPublicationYear "2004" @default.
- W2045851208 type Work @default.
- W2045851208 sameAs 2045851208 @default.
- W2045851208 citedByCount "26" @default.
- W2045851208 countsByYear W20458512082012 @default.
- W2045851208 countsByYear W20458512082013 @default.
- W2045851208 countsByYear W20458512082018 @default.
- W2045851208 countsByYear W20458512082019 @default.
- W2045851208 countsByYear W20458512082021 @default.
- W2045851208 countsByYear W20458512082022 @default.
- W2045851208 countsByYear W20458512082023 @default.
- W2045851208 crossrefType "journal-article" @default.
- W2045851208 hasAuthorship W2045851208A5001799610 @default.
- W2045851208 hasAuthorship W2045851208A5008682550 @default.
- W2045851208 hasAuthorship W2045851208A5015361221 @default.
- W2045851208 hasAuthorship W2045851208A5019484257 @default.
- W2045851208 hasAuthorship W2045851208A5079645996 @default.
- W2045851208 hasAuthorship W2045851208A5090581943 @default.
- W2045851208 hasConcept C105923489 @default.
- W2045851208 hasConcept C112705442 @default.
- W2045851208 hasConcept C145802702 @default.
- W2045851208 hasConcept C150903083 @default.
- W2045851208 hasConcept C178790620 @default.
- W2045851208 hasConcept C185592680 @default.
- W2045851208 hasConcept C203032635 @default.
- W2045851208 hasConcept C207001950 @default.
- W2045851208 hasConcept C22979827 @default.
- W2045851208 hasConcept C2777056448 @default.
- W2045851208 hasConcept C2777477808 @default.
- W2045851208 hasConcept C2778504605 @default.
- W2045851208 hasConcept C43617362 @default.
- W2045851208 hasConcept C519581460 @default.
- W2045851208 hasConcept C55493867 @default.
- W2045851208 hasConcept C71924100 @default.
- W2045851208 hasConcept C86803240 @default.
- W2045851208 hasConcept C98274493 @default.
- W2045851208 hasConceptScore W2045851208C105923489 @default.
- W2045851208 hasConceptScore W2045851208C112705442 @default.
- W2045851208 hasConceptScore W2045851208C145802702 @default.
- W2045851208 hasConceptScore W2045851208C150903083 @default.
- W2045851208 hasConceptScore W2045851208C178790620 @default.
- W2045851208 hasConceptScore W2045851208C185592680 @default.
- W2045851208 hasConceptScore W2045851208C203032635 @default.
- W2045851208 hasConceptScore W2045851208C207001950 @default.
- W2045851208 hasConceptScore W2045851208C22979827 @default.
- W2045851208 hasConceptScore W2045851208C2777056448 @default.
- W2045851208 hasConceptScore W2045851208C2777477808 @default.
- W2045851208 hasConceptScore W2045851208C2778504605 @default.
- W2045851208 hasConceptScore W2045851208C43617362 @default.
- W2045851208 hasConceptScore W2045851208C519581460 @default.
- W2045851208 hasConceptScore W2045851208C55493867 @default.
- W2045851208 hasConceptScore W2045851208C71924100 @default.
- W2045851208 hasConceptScore W2045851208C86803240 @default.
- W2045851208 hasConceptScore W2045851208C98274493 @default.
- W2045851208 hasIssue "2" @default.
- W2045851208 hasLocation W20458512081 @default.
- W2045851208 hasLocation W20458512082 @default.
- W2045851208 hasOpenAccess W2045851208 @default.
- W2045851208 hasPrimaryLocation W20458512081 @default.
- W2045851208 hasRelatedWork W1491964893 @default.
- W2045851208 hasRelatedWork W1982777678 @default.
- W2045851208 hasRelatedWork W1998356222 @default.
- W2045851208 hasRelatedWork W2030336508 @default.
- W2045851208 hasRelatedWork W2056938528 @default.
- W2045851208 hasRelatedWork W2057097799 @default.
- W2045851208 hasRelatedWork W2080913083 @default.
- W2045851208 hasRelatedWork W2753834235 @default.
- W2045851208 hasRelatedWork W2766550598 @default.
- W2045851208 hasRelatedWork W4224326956 @default.