Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045854784> ?p ?o ?g. }
- W2045854784 endingPage "533" @default.
- W2045854784 startingPage "516" @default.
- W2045854784 abstract "Norepinephrine (NE) has been shown to facilitate learning and memory by modulating synaptic plasticity in the hippocampus in vivo. During memory consolidation, transiently stored information is transferred from the hippocampus into the cortical mantle. This process is believed to depend on the generation of sharp wave-ripple complexes (SPW-Rs), during which previously stored information might be replayed. Here, we used rat hippocampal slices to investigate neuromodulatory effects of NE on SPW-Rs, induced by a standard long-term potentiation (LTP) protocol, in the CA3 and CA1. NE (10-50 μM) dose-dependently and reversibly suppressed the generation of SPW-Rs via activation of α1 adrenoreceptors, as indicated by the similar effects of phenylephrine (100 μM). In contrast, the unspecific β adrenoreceptor agonist isoproterenol (2 μM) significantly increased the incidence of SPW-Rs. Furthermore, β adrenoreceptor activation significantly facilitated induction of both LTP and SPW-Rs within the CA3 network. Suppression of SPW-Rs by NE was associated with a moderate hyperpolarization in the majority of CA3 pyramidal cells and with a reduction of presynaptic Ca(2+) uptake in the stratum radiatum. This was indicated by activity-dependent changes in [Ca(2+) ](o) and Ca(2+) fluorescence signals, by changes in the paired pulse ratio of evoked EPSPs and by analysis of the coefficient of variance. In the presence of NE, repeated high frequency stimulation (high-frequency stimulation (HFS)) failed to induce SPW-Rs, although SPW-Rs appeared following washout of NE. Together, our data indicate that the NE-mediated suppression of hippocampal SPW-Rs depends on α1 adrenoreceptor activation, while their expression and activity-dependent induction is facilitated via β1-adrenoreceptors." @default.
- W2045854784 created "2016-06-24" @default.
- W2045854784 creator A5038800388 @default.
- W2045854784 creator A5040412422 @default.
- W2045854784 creator A5043700933 @default.
- W2045854784 creator A5049160621 @default.
- W2045854784 creator A5071194180 @default.
- W2045854784 creator A5081138661 @default.
- W2045854784 creator A5091270897 @default.
- W2045854784 date "2011-01-20" @default.
- W2045854784 modified "2023-10-05" @default.
- W2045854784 title "Adrenergic modulation of sharp wave-ripple activity in rat hippocampal slices" @default.
- W2045854784 cites W1517722692 @default.
- W2045854784 cites W1658103071 @default.
- W2045854784 cites W1815738849 @default.
- W2045854784 cites W1949031418 @default.
- W2045854784 cites W1953105366 @default.
- W2045854784 cites W1966650187 @default.
- W2045854784 cites W1968633203 @default.
- W2045854784 cites W1970138298 @default.
- W2045854784 cites W1973627502 @default.
- W2045854784 cites W1988152811 @default.
- W2045854784 cites W1991463051 @default.
- W2045854784 cites W1994667935 @default.
- W2045854784 cites W2002456390 @default.
- W2045854784 cites W2003106844 @default.
- W2045854784 cites W2003961668 @default.
- W2045854784 cites W2005609503 @default.
- W2045854784 cites W2008025249 @default.
- W2045854784 cites W2011882079 @default.
- W2045854784 cites W2014459859 @default.
- W2045854784 cites W2020272049 @default.
- W2045854784 cites W2021897528 @default.
- W2045854784 cites W2028045674 @default.
- W2045854784 cites W2028216578 @default.
- W2045854784 cites W2030325164 @default.
- W2045854784 cites W2034481695 @default.
- W2045854784 cites W2041458185 @default.
- W2045854784 cites W2041800086 @default.
- W2045854784 cites W2042909340 @default.
- W2045854784 cites W2047750300 @default.
- W2045854784 cites W2056270533 @default.
- W2045854784 cites W2056592977 @default.
- W2045854784 cites W2063615912 @default.
- W2045854784 cites W2071290167 @default.
- W2045854784 cites W2078215907 @default.
- W2045854784 cites W2093963631 @default.
- W2045854784 cites W2094257560 @default.
- W2045854784 cites W2106578924 @default.
- W2045854784 cites W2118168358 @default.
- W2045854784 cites W2120574801 @default.
- W2045854784 cites W2133253913 @default.
- W2045854784 cites W2136574536 @default.
- W2045854784 cites W2141252299 @default.
- W2045854784 cites W2142875089 @default.
- W2045854784 cites W2145661991 @default.
- W2045854784 cites W2150956170 @default.
- W2045854784 cites W2151216904 @default.
- W2045854784 cites W2151542296 @default.
- W2045854784 cites W2152982331 @default.
- W2045854784 cites W2156118860 @default.
- W2045854784 cites W2162071459 @default.
- W2045854784 cites W2403704540 @default.
- W2045854784 doi "https://doi.org/10.1002/hipo.20918" @default.
- W2045854784 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21254303" @default.
- W2045854784 hasPublicationYear "2011" @default.
- W2045854784 type Work @default.
- W2045854784 sameAs 2045854784 @default.
- W2045854784 citedByCount "44" @default.
- W2045854784 countsByYear W20458547842012 @default.
- W2045854784 countsByYear W20458547842013 @default.
- W2045854784 countsByYear W20458547842014 @default.
- W2045854784 countsByYear W20458547842015 @default.
- W2045854784 countsByYear W20458547842016 @default.
- W2045854784 countsByYear W20458547842018 @default.
- W2045854784 countsByYear W20458547842019 @default.
- W2045854784 countsByYear W20458547842020 @default.
- W2045854784 countsByYear W20458547842021 @default.
- W2045854784 countsByYear W20458547842022 @default.
- W2045854784 countsByYear W20458547842023 @default.
- W2045854784 crossrefType "journal-article" @default.
- W2045854784 hasAuthorship W2045854784A5038800388 @default.
- W2045854784 hasAuthorship W2045854784A5040412422 @default.
- W2045854784 hasAuthorship W2045854784A5043700933 @default.
- W2045854784 hasAuthorship W2045854784A5049160621 @default.
- W2045854784 hasAuthorship W2045854784A5071194180 @default.
- W2045854784 hasAuthorship W2045854784A5081138661 @default.
- W2045854784 hasAuthorship W2045854784A5091270897 @default.
- W2045854784 hasConcept C126322002 @default.
- W2045854784 hasConcept C131453863 @default.
- W2045854784 hasConcept C134018914 @default.
- W2045854784 hasConcept C148762608 @default.
- W2045854784 hasConcept C169760540 @default.
- W2045854784 hasConcept C170493617 @default.
- W2045854784 hasConcept C178790620 @default.
- W2045854784 hasConcept C185592680 @default.
- W2045854784 hasConcept C24998067 @default.
- W2045854784 hasConcept C25274449 @default.