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- W2045861280 abstract "Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is performed for treatment of medically intractable dystonia, including primary generalized dystonia, myoclonic dystonia, and cervical dystonia.1-3⇓⇓ There is little experience, however, with other focal dystonias. We present long-term follow-up of chronic pallidal DBS in blepharospasm–oromandibular dystonia (Meige syndrome).A 60-year-old woman with medically refractory Meige syndrome had an unremarkable medical history with no exposure to neuroleptic drugs. At age 55, she noted mild spasms of her tongue. She then developed blepharospasm and involuntary contractions of her lower facial muscles. Dystonia improved after local injections of botulinum toxin (BTX) A, which were repeated over 3 years. Then, a gradual loss of efficacy was noted. Medical treatment did not yield satisfactory improvement or was limited by side effects.When seen in our office she presented with blepharospasm–oromandibular dystonia, involuntary movements of her tongue, and difficulty swallowing. She complained about pain of her temporo-mandibular joints. Medication included trihexyphenidyl, tiapride, tetrazepam, zopiclon, and zolpidem. Her sleep quality was poor, …" @default.
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- W2045861280 date "2003-06-24" @default.
- W2045861280 modified "2023-09-26" @default.
- W2045861280 title "Bilateral pallidal stimulation for blepharospasm-oromandibular dystonia (Meige syndrome)" @default.
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- W2045861280 doi "https://doi.org/10.1212/01.wnl.0000068527.25191.78" @default.
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