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- W2045862488 abstract "We recently reported that non-secretory gastrointestinal smooth muscle cells also possessed SNARE proteins, of which SNAP-25 regulated Ca(2+)-activated (K(Ca)) and delayed rectifier K(+) channels (K(V)). Voltage-gated, long lasting (L-type) calcium channels (L(Ca)) play an important role in excitation-contraction coupling of smooth muscle. Here, we show that SNAP-25 could also directly inhibit the L-type Ca(2+) channels in feline esophageal smooth muscle cells at the SNARE complex binding synprint site. SNARE proteins could therefore regulate additional cell actions other than membrane fusion and secretion, in particular, coordinated muscle membrane excitability and contraction, through their actions on membrane Ca(2+) and K(+) channels." @default.
- W2045862488 created "2016-06-24" @default.
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- W2045862488 date "2003-06-01" @default.
- W2045862488 modified "2023-09-26" @default.
- W2045862488 title "SNAP-25 inhibits L-type Ca2+ channels in feline esophagus smooth muscle cells" @default.
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- W2045862488 doi "https://doi.org/10.1016/s0006-291x(03)00968-9" @default.
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